Natural mutations in key NLS amino acids regulate nucleoplasmic shuttling and replication efficiency in PRRSV

Natural mutations in key NLS amino acids regulate nucleoplasmic shuttling and replication efficiency in PRRSV

Highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) is a mutant strain of the classic porcine reproductive and respiratory syndrome virus (PRRSV) characterized by high morbidity and mortality rates. Epidemiological analysis revealed a natural mutation and stable inherita...

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Bibliographic Details
Main Authors: Xianchang Zhu, Yang Xia, Qian Lei, Yu Gan, Shenghai Jiang, Lian Huang, Qihu Wen, Wei Fu, Bo Zhang, Yi Zhang, Shanshan Xie, Jida Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Microbiology
Subjects:
PRRSV
nucleocapsid protein
NLS
NTR
nuclear-mass shuttle
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1587634/full
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