Alendronate nanoparticles promote fracture healing by inhibiting LRP4 to activate the Wnt/β-catenin pathway

Alendronate nanoparticles promote fracture healing by inhibiting LRP4 to activate the Wnt/β-catenin pathway

Background: Fracture is a common skeletal disorder, and fracture healing is a complex biological process. The Wingless-Int-Integrated/beta-catenin (Wnt/β-catenin) signaling pathway plays an important role in bone formation and fracture healing. Low-density lipoprotein receptor-related protein 4 (LRP...

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Bibliographic Details
Main Authors: ZW Sun, QL Zhu, JP Gong, YH Sui, XY Liu
Format: Article
Language:English
Published: Forum Multimedia Publishing LLC 2025-06-01
Series:European Cells & Materials
Subjects:
alendronate nanoparticles
lrp4
wnt/β-catenin pathway
bone-fracture healing
Online Access:https://www.ecmjournal.org/papers/vol051/vol051a06.php
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