Novel Quaternary Ammonium Salt‐Linked STING Agonist Antibody‐Drug Conjugate: Synergistic Activation of Tumor Immunity with Mitigated Off‐Target Toxicity

Novel Quaternary Ammonium Salt‐Linked STING Agonist Antibody‐Drug Conjugate: Synergistic Activation of Tumor Immunity with Mitigated Off‐Target Toxicity

Abstract Immune‐stimulating antibody conjugate (ISACs) incorporating STING agonists as payloads leverage both the targeting capability of the Fab region and the Fc region‐mediated tumor antigen‐dependent immune activation. Herein, a novel class of ISACs is reported, generated by engineering a quater...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yu Long, Borui Tang, Fei Xie, Lianqi Liu, Yangyihua Zhou, Jingwen Dong, Jianfeng Wang, Cuicui Sun, Yuting Wang, Ruoqi Li, Na Zhang, Liping Li, Longlong Luo, Junhai Xiao, Wu Zhong, Dian Xiao, Hongbin Deng, Xinbo Zhou
Format:	Article
Language:	English
Published:	Wiley 2025-08-01
Series:	Advanced Science
Subjects:	antitumor immunity diABZI STING agonist 3 immune‐stimulating antibody conjugates quaternary ammonium salt‐linker stimulator of interferon genes
Online Access:	https://doi.org/10.1002/advs.202502270
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

The influence of quaternary ammonium salts on mechanical properties of light-cured resin dental composites
by: Maja Zalega, et al.
Published: (2023-04-01)

Preparation of quaternary ammonium-modified silica and its adsorption of vanadium(V)
by: ZHANG Cuihong, et al.
Published: (2025-01-01)

Ionic quaternary ammonium-triazole polymers as efficient single-component catalysts for CO2 conversion
by: Pobporn Promchan, et al.
Published: (2024-12-01)

Synthesis and anticorrosive activity of <i>tert</i>-amines containing cycloacetal or <i>gem</i>-dichlorocyclopropane fragments and quaternary ammonium salts on their basis
by: Yu. G. Borisova, et al.
Published: (2025-07-01)

Is it time to re-evaluate exposure risks to quaternary ammonium compounds as disinfectants?
by: Jason A. Tetro, et al.
Published: (2024-01-01)

Evaluation of the Effects of the Quaternary Ammonium Silane K21 on Zebrafish Viability, Toxicity, Growth, and Development
by: Surendra K. Rajpurohit, et al.
Published: (2025-05-01)

Next‐Generation HER‐2 Tumor‐Targeted Delivery of the STING Agonist Immune‐Stimulating Antibody Conjugate (ISAC) Improves Anticancer Efficacy and Induces Immunological Memory
by: Gang Wu, et al.
Published: (2025-07-01)

Conjugated STING agonists
by: Shuhao Qu, et al.
Published: (2025-06-01)

Novel Quaternary Ammonium Urethane-Dimethacrylates for Copolymers with Low Water Sorption and Solubility
by: Patryk Drejka, et al.
Published: (2025-02-01)

Synthesis of Indole-Based Derivatives Containing Ammonium Salts, Diamines and Aminoureas for Organocatalysis
by: Marcello Casertano, et al.
Published: (2025-04-01)

Boosting the Antimicrobial Activity of Quaternary Ammonium Photosensitizers by Janus‐Type AIE Luminogens
by: Dongyang Fan, et al.
Published: (2025-08-01)

EVALUATION OF THE ANTIMICROBIAL EFFECTS OF NEW HETEROCYCLIC BIS-QUATERNARY AMMONIUM COMPOUNDS ON BIOFILMS
by: OANA E. CONSTANTIN, et al.
Published: (2016-07-01)

Unlocking molecular dynamics: incorporation of volumetric insights into l-glutamic acid and quaternary ammonium bromides in aqueous medium
by: Harapriya Panda, et al.
Published: (2025-07-01)

From sting to STING: role of inflammation in wasp sting induced AKI - a narrative review
by: Liang Xu, et al.
Published: (2025-08-01)

Effect of the Incorporation of an Innovative Monomer with a Quaternary Ammonium Group into a Temporary Soft Liner on Its Biological and Physicochemical Properties
by: Patrycja Kula, et al.
Published: (2025-02-01)

Dual Biocide Behaviour of Quaternary Ammonium Functionalized Mesoporous Silica Nanoparticles Loaded with Thymus Essential Oil for Stone Conservation
by: Federico Olivieri, et al.
Published: (2025-06-01)

The cGAS‒STING pathway in cancer immunity: mechanisms, challenges, and therapeutic implications
by: Mengzhou Shen, et al.
Published: (2025-04-01)

EFFECT OF DISINFECTANTS BASED ON POTASSIUM PERSULFATE, HYDROGEN PEROXIDE, GLUTARALDEHYDE AND QUATERNARY AMMONIUM COMPOUNDS ON THE GENETIC MATERIAL OF THE PATHOGEN BACTERIA SPECIFIC TO MEAT PROCESSING INDUSTRY
by: V. N. Afonyushkin, et al.
Published: (2016-06-01)

STING-ΔN, a novel splice isoform of STING, modulates innate immunity and autophagy in response to DNA virus infection
by: Jian Deng, et al.
Published: (2025-06-01)

The role of inflammation in wasp sting-induced acute kidney injury
by: Xia Ling-ya, et al.
Published: (2025-05-01)

PRRSV evades innate immune cGAS-STING antiviral function via its Nsp5 to deter STING translocation and activation
by: Yulin Xu, et al.
Published: (2025-12-01)

Selective flotation of silicates from phosphates using Tetrabutyl Ammonium Chloride as a green collector
by: Ashraf Alsafasfeh
Published: (2025-01-01)

The role of cGAS-STING pathway ubiquitination in innate immunity and multiple diseases
by: Chunyan Deng, et al.
Published: (2025-02-01)

Spatiotemporal Regulation of STING Activity by Linear Ubiquitination Governs Antiviral Immunity
by: Yong Zhang, et al.
Published: (2025-07-01)

The Use of Tetramethylbenzidine as an Indicator in the Enzymatic Quantitative Determination of Ethonium
by: Olena V. Kovalska, et al.
Published: (2024-12-01)

Manipulating the cGAS-STING Axis: advancing innovative strategies for osteosarcoma therapeutics
by: BingBing Li, et al.
Published: (2025-02-01)

The unexpected role of the STING protein in lipid metabolism
by: Vila, Isabelle K., et al.
Published: (2023-04-01)

Cell biological insights into human STING variants
by: Shogo Koide, et al.
Published: (2025-05-01)

Functional Characterization of a Novel SMR-Type Efflux Pump RanQ, Mediating Quaternary Ammonium Compound Resistance in <i>Riemerella anatipestifer</i>
by: Heng Quan, et al.
Published: (2023-03-01)

A quantitative method to monitor STING degradation with dual-luciferase reporters
by: Tsumugi Shoji, et al.
Published: (2025-04-01)

Regulation and Function of the cGAS-STING Pathway: Mechanisms, Post-Translational Modifications, and Therapeutic Potential in Immunotherapy
by: Chen Y, et al.
Published: (2025-03-01)

Dual regulation of the cGAS-STING pathway: new targets and challenges for subtype-specific immunotherapy in breast cancer
by: Hanchu Xiong, et al.
Published: (2025-06-01)

STING exerts antiviral innate immune response by activating pentose phosphate pathway
by: Dan-Hui Wu, et al.
Published: (2024-12-01)

Suggestions on converting ammonium nitrate manufacturing capacity for production of porous ammonium nitrates and ammonium nitrate with fillers
by: A. L. Taran, et al.
Published: (2009-12-01)

Ring finger protein 5 mediates STING degradation through ubiquitinating K135 and K155 in a teleost fish
by: Xiaowei Qin, et al.
Published: (2024-12-01)

Bioinformatic characterization of STING expression in hematological malignancies reveals association with prognosis and anti-tumor immunity
by: Xiang-mei Wen, et al.
Published: (2025-02-01)

The cGAS-STING pathway: a dual regulator of immune response in cancer and therapeutic implications
by: Zhanghao Huang, et al.
Published: (2025-07-01)

Duck plague virus US3 kinase phosphorylates and induces STING degradation to inhibit innate immune responses
by: Bin Tian, et al.
Published: (2025-08-01)

Ginkgetin Alleviates Inflammation and Senescence by Targeting STING
by: Yadan Liu, et al.
Published: (2025-01-01)

Study on the constructions of optimal almost quaternary sequences with period 2q
by: Xiuping PENG, et al.
Published: (2019-12-01)