The Role of Exosomes in Cancer Progression and Therapy
Exosomes are small extracellular vesicles and are crucial in intercellular communication. Interestingly, tumor-derived exosomes carry oncogenic molecules, such as proteins and microRNAs, which can reprogram recipient cells, promote angiogenesis, and stimulate cancer pre-metastatic niche, supporting...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/14/1/27 |
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| author | Shynggys Sergazy Roza Seydahmetova Alexandr Gulyayev Zarina Shulgau Mohamad Aljofan |
| author_facet | Shynggys Sergazy Roza Seydahmetova Alexandr Gulyayev Zarina Shulgau Mohamad Aljofan |
| author_sort | Shynggys Sergazy |
| collection | DOAJ |
| description | Exosomes are small extracellular vesicles and are crucial in intercellular communication. Interestingly, tumor-derived exosomes carry oncogenic molecules, such as proteins and microRNAs, which can reprogram recipient cells, promote angiogenesis, and stimulate cancer pre-metastatic niche, supporting cancer growth and metastasis. On the other hand, their biocompatibility, stability, and ability to cross biological barriers make them attractive candidates for drug delivery. Recent advances have shown the potential for exosomes to be used in early disease detection and in targeted drug therapy by delivering therapeutic agents specifically to tumor sites. Despite the promising applications, a number of challenges remain, including exosome isolation and characterization, as well as their inherent heterogeneity. Thus, the current review aims to describe the roles of exosomes in health and disease, and discuss the challenges that hinder their development into becoming useful medical tools. |
| format | Article |
| id | doaj-art-c329226f3dfe4cde80e0f06a0a11e985 |
| institution | Kabale University |
| issn | 2079-7737 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj-art-c329226f3dfe4cde80e0f06a0a11e9852025-01-24T13:23:21ZengMDPI AGBiology2079-77372025-01-011412710.3390/biology14010027The Role of Exosomes in Cancer Progression and TherapyShynggys Sergazy0Roza Seydahmetova1Alexandr Gulyayev2Zarina Shulgau3Mohamad Aljofan4LLP VICTUS PHARM, Astana 010000, KazakhstanLLP VICTUS PHARM, Astana 010000, KazakhstanLLP VICTUS PHARM, Astana 010000, KazakhstanLLP VICTUS PHARM, Astana 010000, KazakhstanNational Laboratory Astana, Center for Life Sciences, Nazarbayev University, Astana 010000, KazakhstanExosomes are small extracellular vesicles and are crucial in intercellular communication. Interestingly, tumor-derived exosomes carry oncogenic molecules, such as proteins and microRNAs, which can reprogram recipient cells, promote angiogenesis, and stimulate cancer pre-metastatic niche, supporting cancer growth and metastasis. On the other hand, their biocompatibility, stability, and ability to cross biological barriers make them attractive candidates for drug delivery. Recent advances have shown the potential for exosomes to be used in early disease detection and in targeted drug therapy by delivering therapeutic agents specifically to tumor sites. Despite the promising applications, a number of challenges remain, including exosome isolation and characterization, as well as their inherent heterogeneity. Thus, the current review aims to describe the roles of exosomes in health and disease, and discuss the challenges that hinder their development into becoming useful medical tools.https://www.mdpi.com/2079-7737/14/1/27exosomesdrug deliverytumor-derived exosomescancer therapyextracellular vesiclestumor microenvironment |
| spellingShingle | Shynggys Sergazy Roza Seydahmetova Alexandr Gulyayev Zarina Shulgau Mohamad Aljofan The Role of Exosomes in Cancer Progression and Therapy Biology exosomes drug delivery tumor-derived exosomes cancer therapy extracellular vesicles tumor microenvironment |
| title | The Role of Exosomes in Cancer Progression and Therapy |
| title_full | The Role of Exosomes in Cancer Progression and Therapy |
| title_fullStr | The Role of Exosomes in Cancer Progression and Therapy |
| title_full_unstemmed | The Role of Exosomes in Cancer Progression and Therapy |
| title_short | The Role of Exosomes in Cancer Progression and Therapy |
| title_sort | role of exosomes in cancer progression and therapy |
| topic | exosomes drug delivery tumor-derived exosomes cancer therapy extracellular vesicles tumor microenvironment |
| url | https://www.mdpi.com/2079-7737/14/1/27 |
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