Tumor microenvironment in oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) is a highly aggressive and malignant tumor of oral cavity with a poor prognosis and high mortality due to the limitations of existing therapies. The significant role of tumor microenvironment (TME) in the initiation, development, and progression of OSCC has been w...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1485174/full |
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| _version_ | 1850113586624462848 |
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| author | Chenxi Li Xiaodan Dong Bo Li |
| author_facet | Chenxi Li Xiaodan Dong Bo Li |
| author_sort | Chenxi Li |
| collection | DOAJ |
| description | Oral squamous cell carcinoma (OSCC) is a highly aggressive and malignant tumor of oral cavity with a poor prognosis and high mortality due to the limitations of existing therapies. The significant role of tumor microenvironment (TME) in the initiation, development, and progression of OSCC has been widely recognized. Various cells in TME, including tumor-associated macrophages (TAMs), cancer-associated fibroblasts (CAFs), T lymphocytes, tumor-associated neutrophils (TANs), myeloid-derived suppressor cells (MDSCs) and dendritic cells (DCs), form a complicated and important cellular network to modulate OSCC proliferation, invasion, migration, and angiogenesis by secreting RNAs, proteins, cytokines, and metabolites. Understanding the interactions among cells in TME provides the foundation for advanced clinical diagnosis and therapies. This review summarizes the current literature that describes the role of various cellular components and other TME factors in the progression of OSCC, hoping to provide new ideas for the novel OSCC treatment strategies targeting the complicated cellular network and factors that mediate the interactive loops among cells in TME. |
| format | Article |
| id | doaj-art-c3279e959b274914b01afd46d098d2d1 |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-c3279e959b274914b01afd46d098d2d12025-08-20T02:37:06ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-12-011510.3389/fimmu.2024.14851741485174Tumor microenvironment in oral squamous cell carcinomaChenxi LiXiaodan DongBo LiOral squamous cell carcinoma (OSCC) is a highly aggressive and malignant tumor of oral cavity with a poor prognosis and high mortality due to the limitations of existing therapies. The significant role of tumor microenvironment (TME) in the initiation, development, and progression of OSCC has been widely recognized. Various cells in TME, including tumor-associated macrophages (TAMs), cancer-associated fibroblasts (CAFs), T lymphocytes, tumor-associated neutrophils (TANs), myeloid-derived suppressor cells (MDSCs) and dendritic cells (DCs), form a complicated and important cellular network to modulate OSCC proliferation, invasion, migration, and angiogenesis by secreting RNAs, proteins, cytokines, and metabolites. Understanding the interactions among cells in TME provides the foundation for advanced clinical diagnosis and therapies. This review summarizes the current literature that describes the role of various cellular components and other TME factors in the progression of OSCC, hoping to provide new ideas for the novel OSCC treatment strategies targeting the complicated cellular network and factors that mediate the interactive loops among cells in TME.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1485174/fulloral squamous cell carcinomatumor microenvironmenttumor-associated macrophagesinteractioncellular network |
| spellingShingle | Chenxi Li Xiaodan Dong Bo Li Tumor microenvironment in oral squamous cell carcinoma Frontiers in Immunology oral squamous cell carcinoma tumor microenvironment tumor-associated macrophages interaction cellular network |
| title | Tumor microenvironment in oral squamous cell carcinoma |
| title_full | Tumor microenvironment in oral squamous cell carcinoma |
| title_fullStr | Tumor microenvironment in oral squamous cell carcinoma |
| title_full_unstemmed | Tumor microenvironment in oral squamous cell carcinoma |
| title_short | Tumor microenvironment in oral squamous cell carcinoma |
| title_sort | tumor microenvironment in oral squamous cell carcinoma |
| topic | oral squamous cell carcinoma tumor microenvironment tumor-associated macrophages interaction cellular network |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1485174/full |
| work_keys_str_mv | AT chenxili tumormicroenvironmentinoralsquamouscellcarcinoma AT xiaodandong tumormicroenvironmentinoralsquamouscellcarcinoma AT boli tumormicroenvironmentinoralsquamouscellcarcinoma |