Cannabinoids and the endocannabinoid system in the regulation of cytochrome P450 metabolic activity-a review
The use of cannabinoids has a history spanning thousands of years, and their pharmacological and toxicological properties, particularly those of THC and CBD, are well-documented. However, their potential to induce drug-drug interactions remains underexplored. This review aims to provide a comprehens...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1599012/full |
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| author | Carlos D.F. Fonseca Ondřej Zendulka Jan Juřica Jan Juřica Jan Juřica |
| author_facet | Carlos D.F. Fonseca Ondřej Zendulka Jan Juřica Jan Juřica Jan Juřica |
| author_sort | Carlos D.F. Fonseca |
| collection | DOAJ |
| description | The use of cannabinoids has a history spanning thousands of years, and their pharmacological and toxicological properties, particularly those of THC and CBD, are well-documented. However, their potential to induce drug-drug interactions remains underexplored. This review aims to provide a comprehensive perspective by contextualizing the historical and pharmacological significance of cannabinoids while focusing on their capacity to modulate the metabolic activity of cytochrome P450 isoforms relevant to drug metabolism. Additionally, we look at the impact of cannabinoids in neuronal circuits impacting the hypothalamic-pituitary hormonal axis, such as the locus coeruleus and raphe nuclei and their possible consequences on the cytochrome P450 system. Recognising potential interactions between cannabinoids and other drugs could enhance understanding of their pharmacological effects, improve the efficacy and safety profiles of cannabinoid-based therapies, and encourage further exploration into this under-researched area of psychopharmacology, with implications for both preclinical research and clinical practice. |
| format | Article |
| id | doaj-art-c326a5aa021a4b8a9c4e368752675ae6 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-c326a5aa021a4b8a9c4e368752675ae62025-08-20T03:25:59ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-06-011610.3389/fphar.2025.15990121599012Cannabinoids and the endocannabinoid system in the regulation of cytochrome P450 metabolic activity-a reviewCarlos D.F. Fonseca0Ondřej Zendulka1Jan Juřica2Jan Juřica3Jan Juřica4Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, CzechiaDepartment of Pharmacology, Faculty of Medicine, Masaryk University, Brno, CzechiaDepartment of Pharmacology, Faculty of Medicine, Masaryk University, Brno, CzechiaMasaryk Memorial Cancer Institute, Brno, CzechiaDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Masaryk University, Brno, CzechiaThe use of cannabinoids has a history spanning thousands of years, and their pharmacological and toxicological properties, particularly those of THC and CBD, are well-documented. However, their potential to induce drug-drug interactions remains underexplored. This review aims to provide a comprehensive perspective by contextualizing the historical and pharmacological significance of cannabinoids while focusing on their capacity to modulate the metabolic activity of cytochrome P450 isoforms relevant to drug metabolism. Additionally, we look at the impact of cannabinoids in neuronal circuits impacting the hypothalamic-pituitary hormonal axis, such as the locus coeruleus and raphe nuclei and their possible consequences on the cytochrome P450 system. Recognising potential interactions between cannabinoids and other drugs could enhance understanding of their pharmacological effects, improve the efficacy and safety profiles of cannabinoid-based therapies, and encourage further exploration into this under-researched area of psychopharmacology, with implications for both preclinical research and clinical practice.https://www.frontiersin.org/articles/10.3389/fphar.2025.1599012/fullcannabinoidsendocannabinoid systemcytochrome P450metabolismhypothalamic-pituitary axiscannabinoid-based therapies |
| spellingShingle | Carlos D.F. Fonseca Ondřej Zendulka Jan Juřica Jan Juřica Jan Juřica Cannabinoids and the endocannabinoid system in the regulation of cytochrome P450 metabolic activity-a review Frontiers in Pharmacology cannabinoids endocannabinoid system cytochrome P450 metabolism hypothalamic-pituitary axis cannabinoid-based therapies |
| title | Cannabinoids and the endocannabinoid system in the regulation of cytochrome P450 metabolic activity-a review |
| title_full | Cannabinoids and the endocannabinoid system in the regulation of cytochrome P450 metabolic activity-a review |
| title_fullStr | Cannabinoids and the endocannabinoid system in the regulation of cytochrome P450 metabolic activity-a review |
| title_full_unstemmed | Cannabinoids and the endocannabinoid system in the regulation of cytochrome P450 metabolic activity-a review |
| title_short | Cannabinoids and the endocannabinoid system in the regulation of cytochrome P450 metabolic activity-a review |
| title_sort | cannabinoids and the endocannabinoid system in the regulation of cytochrome p450 metabolic activity a review |
| topic | cannabinoids endocannabinoid system cytochrome P450 metabolism hypothalamic-pituitary axis cannabinoid-based therapies |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1599012/full |
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