Mechanisms of glutamate metabolic function and dysfunction in vascular dementia
Abstract As the global population ages, research on the pathogenesis and treatment options for older patients with dementia has become increasingly important. Vascular dementia (VaD), the second most frequent type of dementia, is characterized by vascular impairment caused by inadequate blood supply...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-03-01
|
| Series: | Neuroprotection |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/nep3.32 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849430991888711680 |
|---|---|
| author | Jiawen Wang Yingmei Zhang Ning Tian Dongshan Ya Jiaxin Yang Yanlin Jiang Xiaoxia Li Xiaohui Lin Bin Yang Qinghua Li Rujia Liao |
| author_facet | Jiawen Wang Yingmei Zhang Ning Tian Dongshan Ya Jiaxin Yang Yanlin Jiang Xiaoxia Li Xiaohui Lin Bin Yang Qinghua Li Rujia Liao |
| author_sort | Jiawen Wang |
| collection | DOAJ |
| description | Abstract As the global population ages, research on the pathogenesis and treatment options for older patients with dementia has become increasingly important. Vascular dementia (VaD), the second most frequent type of dementia, is characterized by vascular impairment caused by inadequate blood supply to the brain. VaD is a complex neurological disorder involving multiple cells and signaling pathways, and its prevention and treatment pose clinical challenges with significant behavioral implications. Glutamate, the most abundant amino acid in the brain, plays a critical role as an excitatory neurotransmitter, impacting cognitive function, learning, and memory. Abnormal glutamate metabolism has been closely linked to dementia, and reduced blood flow to the brain can lead to excessive glutamate accumulation, resulting in neuronal death. This article highlights the connection between VaD and glutamate metabolism, aiming to identify better methods for preventing and treating VaD via regulating glutamate metabolism. |
| format | Article |
| id | doaj-art-c322d52011de4c0a80ae7fcd1774c173 |
| institution | Kabale University |
| issn | 2770-7296 2770-730X |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neuroprotection |
| spelling | doaj-art-c322d52011de4c0a80ae7fcd1774c1732025-08-20T03:27:47ZengWileyNeuroprotection2770-72962770-730X2024-03-0121334810.1002/nep3.32Mechanisms of glutamate metabolic function and dysfunction in vascular dementiaJiawen Wang0Yingmei Zhang1Ning Tian2Dongshan Ya3Jiaxin Yang4Yanlin Jiang5Xiaoxia Li6Xiaohui Lin7Bin Yang8Qinghua Li9Rujia Liao10Laboratory of Neuroscience, Affiliated Hospital of Guilin Medical University Guilin Medical University Guilin Guangxi ChinaLaboratory of Neuroscience, Affiliated Hospital of Guilin Medical University Guilin Medical University Guilin Guangxi ChinaLaboratory of Neuroscience, Affiliated Hospital of Guilin Medical University Guilin Medical University Guilin Guangxi ChinaLaboratory of Neuroscience, Affiliated Hospital of Guilin Medical University Guilin Medical University Guilin Guangxi ChinaLaboratory of Neuroscience, Affiliated Hospital of Guilin Medical University Guilin Medical University Guilin Guangxi ChinaDepartment of Pharmacology, Affiliated Hospital of Guilin Medical University Guilin Medical University Guilin Guangxi ChinaLaboratory of Neuroscience, Affiliated Hospital of Guilin Medical University Guilin Medical University Guilin Guangxi ChinaDepartment of Geriatrics, Affiliated Hospital of Guilin Medical University Guilin Medical University Guilin Guangxi ChinaGuangxi Clinical Research Center for Neurological Diseases, Affiliated Hospital of Guilin Medical University Guilin Medical University Guilin Guangxi ChinaLaboratory of Neuroscience, Affiliated Hospital of Guilin Medical University Guilin Medical University Guilin Guangxi ChinaLaboratory of Neuroscience, Affiliated Hospital of Guilin Medical University Guilin Medical University Guilin Guangxi ChinaAbstract As the global population ages, research on the pathogenesis and treatment options for older patients with dementia has become increasingly important. Vascular dementia (VaD), the second most frequent type of dementia, is characterized by vascular impairment caused by inadequate blood supply to the brain. VaD is a complex neurological disorder involving multiple cells and signaling pathways, and its prevention and treatment pose clinical challenges with significant behavioral implications. Glutamate, the most abundant amino acid in the brain, plays a critical role as an excitatory neurotransmitter, impacting cognitive function, learning, and memory. Abnormal glutamate metabolism has been closely linked to dementia, and reduced blood flow to the brain can lead to excessive glutamate accumulation, resulting in neuronal death. This article highlights the connection between VaD and glutamate metabolism, aiming to identify better methods for preventing and treating VaD via regulating glutamate metabolism.https://doi.org/10.1002/nep3.32glutamateionotropic glutamate receptorsmetabolismmetabotropic glutamate receptorsvascular dementia |
| spellingShingle | Jiawen Wang Yingmei Zhang Ning Tian Dongshan Ya Jiaxin Yang Yanlin Jiang Xiaoxia Li Xiaohui Lin Bin Yang Qinghua Li Rujia Liao Mechanisms of glutamate metabolic function and dysfunction in vascular dementia Neuroprotection glutamate ionotropic glutamate receptors metabolism metabotropic glutamate receptors vascular dementia |
| title | Mechanisms of glutamate metabolic function and dysfunction in vascular dementia |
| title_full | Mechanisms of glutamate metabolic function and dysfunction in vascular dementia |
| title_fullStr | Mechanisms of glutamate metabolic function and dysfunction in vascular dementia |
| title_full_unstemmed | Mechanisms of glutamate metabolic function and dysfunction in vascular dementia |
| title_short | Mechanisms of glutamate metabolic function and dysfunction in vascular dementia |
| title_sort | mechanisms of glutamate metabolic function and dysfunction in vascular dementia |
| topic | glutamate ionotropic glutamate receptors metabolism metabotropic glutamate receptors vascular dementia |
| url | https://doi.org/10.1002/nep3.32 |
| work_keys_str_mv | AT jiawenwang mechanismsofglutamatemetabolicfunctionanddysfunctioninvasculardementia AT yingmeizhang mechanismsofglutamatemetabolicfunctionanddysfunctioninvasculardementia AT ningtian mechanismsofglutamatemetabolicfunctionanddysfunctioninvasculardementia AT dongshanya mechanismsofglutamatemetabolicfunctionanddysfunctioninvasculardementia AT jiaxinyang mechanismsofglutamatemetabolicfunctionanddysfunctioninvasculardementia AT yanlinjiang mechanismsofglutamatemetabolicfunctionanddysfunctioninvasculardementia AT xiaoxiali mechanismsofglutamatemetabolicfunctionanddysfunctioninvasculardementia AT xiaohuilin mechanismsofglutamatemetabolicfunctionanddysfunctioninvasculardementia AT binyang mechanismsofglutamatemetabolicfunctionanddysfunctioninvasculardementia AT qinghuali mechanismsofglutamatemetabolicfunctionanddysfunctioninvasculardementia AT rujialiao mechanismsofglutamatemetabolicfunctionanddysfunctioninvasculardementia |