Cell Therapy in Chagas Disease
Chagas disease which is caused by the parasite Trypanosoma cruzi is an important cause of cardiomyopathy in Latin America. In later stages chagasic cardiomyopathy is associated with congestive heart failure which is often refractory to medical therapy. In these individuals heart transplantation has...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2009/484358 |
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| author | Antonio C. Campos de Carvalho Regina C. S. Goldenberg Linda A. Jelicks Milena B. P. Soares Ricardo Ribeiro dos Santos David C. Spray Herbert B. Tanowitz |
| author_facet | Antonio C. Campos de Carvalho Regina C. S. Goldenberg Linda A. Jelicks Milena B. P. Soares Ricardo Ribeiro dos Santos David C. Spray Herbert B. Tanowitz |
| author_sort | Antonio C. Campos de Carvalho |
| collection | DOAJ |
| description | Chagas disease which is caused by the parasite Trypanosoma cruzi is an important cause of cardiomyopathy in Latin America. In later stages chagasic cardiomyopathy is associated with congestive heart failure which is often refractory to medical therapy. In these individuals heart transplantation has been attempted. However, this procedure is fraught with many problems attributable to the surgery and the postsurgical administration of immunosuppressive drugs. Studies in mice suggest that the transplantation of bone-marrow-derived cells ameliorates the inflammation and fibrosis in the heart associated with this infection. Cardiac magnetic resonance imaging reveals that bone marrow transplantation ameliorates the infection induced right ventricular enlargement. On the basis of these animal studies the safety of autologous bone marrow transplantation has been assessed in patients with chagasic end-stage heart disease. The initial results are encouraging and more studies need to be performed. |
| format | Article |
| id | doaj-art-c31be53e42e44012b4ea3136aff95d14 |
| institution | DOAJ |
| issn | 1687-708X 1687-7098 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-c31be53e42e44012b4ea3136aff95d142025-08-20T03:23:15ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-708X1687-70982009-01-01200910.1155/2009/484358484358Cell Therapy in Chagas DiseaseAntonio C. Campos de Carvalho0Regina C. S. Goldenberg1Linda A. Jelicks2Milena B. P. Soares3Ricardo Ribeiro dos Santos4David C. Spray5Herbert B. Tanowitz6Instituto Nacional de Cardiologia, 22240-006 Rio de Janeiro, RJ, BrazilInstituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 21941-590 Rio de Janeiro, RJ, BrazilDepartment of Physiology & Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USACentro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, 40296-70 Salvador, BA, BrazilCentro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, 40296-70 Salvador, BA, BrazilDominick P. Purpura, Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USADepartment of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USAChagas disease which is caused by the parasite Trypanosoma cruzi is an important cause of cardiomyopathy in Latin America. In later stages chagasic cardiomyopathy is associated with congestive heart failure which is often refractory to medical therapy. In these individuals heart transplantation has been attempted. However, this procedure is fraught with many problems attributable to the surgery and the postsurgical administration of immunosuppressive drugs. Studies in mice suggest that the transplantation of bone-marrow-derived cells ameliorates the inflammation and fibrosis in the heart associated with this infection. Cardiac magnetic resonance imaging reveals that bone marrow transplantation ameliorates the infection induced right ventricular enlargement. On the basis of these animal studies the safety of autologous bone marrow transplantation has been assessed in patients with chagasic end-stage heart disease. The initial results are encouraging and more studies need to be performed.http://dx.doi.org/10.1155/2009/484358 |
| spellingShingle | Antonio C. Campos de Carvalho Regina C. S. Goldenberg Linda A. Jelicks Milena B. P. Soares Ricardo Ribeiro dos Santos David C. Spray Herbert B. Tanowitz Cell Therapy in Chagas Disease Interdisciplinary Perspectives on Infectious Diseases |
| title | Cell Therapy in Chagas Disease |
| title_full | Cell Therapy in Chagas Disease |
| title_fullStr | Cell Therapy in Chagas Disease |
| title_full_unstemmed | Cell Therapy in Chagas Disease |
| title_short | Cell Therapy in Chagas Disease |
| title_sort | cell therapy in chagas disease |
| url | http://dx.doi.org/10.1155/2009/484358 |
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