Experimental Insights and Recommendations for Successfully Performing Cerebral Microdialysis With Hydrophobic Drug Candidates

Experimental Insights and Recommendations for Successfully Performing Cerebral Microdialysis With Hydrophobic Drug Candidates

ABSTRACT Cerebral microdialysis in rodents represents a robust and versatile technique for quantifying the pharmacologically relevant unbound fraction of drugs in the brain. When this unbound fraction is simultaneously determined in plasma, it facilitates the calculation of the corresponding unbound...

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Bibliographic Details
Main Authors: Julia K. Sundheimer, Julia Benzel, Rémi Longuespée, Jürgen Burhenne, Stefan M. Pfister, Kendra K. Maaß, Max Sauter, Kristian W. Pajtler
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Clinical and Translational Science
Subjects:
central nervous system
cerebral microdialysis
chemical drug properties
non‐specific binding
probe implantation
Online Access:https://doi.org/10.1111/cts.70226
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