Influence of silver nitrate on the mechanical properties of orthopedic bone cement and in vitro antibacterial activity
This study aimed to evaluate the influence of silver nitrate (AgNO3) on the mechanical properties of polymethyl methacrylate (PMMA) bone cement by static testing and in vitro antibacterial activity. Two groups were formed: Group 1, control (n=10); and Group 2, cement with silver nitrate (n=10). In...
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| Format: | Article |
| Language: | English |
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Universidade Federal de Goiás
2025-02-01
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| Series: | Ciência Animal Brasileira |
| Online Access: | https://revistas.ufg.br/vet/article/view/79814 |
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| author | Aline Osowski Sheila Canevese Rahal Celso Roberto Ribeiro Luiz Donizete Campeiro Junior José Ivaldo de Siqueira Silva Júnior Guilherme Rech Cassanego Paulo Henrique Gilio Gasparotto |
| author_facet | Aline Osowski Sheila Canevese Rahal Celso Roberto Ribeiro Luiz Donizete Campeiro Junior José Ivaldo de Siqueira Silva Júnior Guilherme Rech Cassanego Paulo Henrique Gilio Gasparotto |
| author_sort | Aline Osowski |
| collection | DOAJ |
| description |
This study aimed to evaluate the influence of silver nitrate (AgNO3) on the mechanical
properties of polymethyl methacrylate (PMMA) bone cement by static testing and in vitro
antibacterial activity. Two groups were formed: Group 1, control (n=10); and Group 2, cement
with silver nitrate (n=10). In Group 1, the cement was prepared manually by mixing 20 g of
PMMA powder with 10 ml of methyl methacrylate liquid. In Group 2, the cement was prepared
as in Group 1; however, 0.25 g of silver nitrate was added to 20 g of PMMA powder. No statistical
differences were observed for bending strength with (61.80 ± 4.96 MPa) or without silver nitrate
(60.20 ± 5.88 MPa). Statistical differences were verified in the higher compressive strength
for the control (78.60 ± 3.20 MPa) compared to cement with silver nitrate specimens (74.20
± 1.61 MPa). Antimicrobial sensitivity testing showed no effect of cement with silver nitrate
on Staphylococcus aureus, Streptococcus sp., Pseudomonas aeruginosa, and Escherichia coli. In
conclusion, the concentration of silver nitrate did not change the mechanical properties of the
PMMA bone cement in the bending test, but it had a negative effect in the compression testing.
In addition, the product did not reduce the bacterial load in the in vitro test.
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| format | Article |
| id | doaj-art-c319f7b31d9142fab768bc5f80667ad8 |
| institution | DOAJ |
| issn | 1518-2797 1809-6891 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Universidade Federal de Goiás |
| record_format | Article |
| series | Ciência Animal Brasileira |
| spelling | doaj-art-c319f7b31d9142fab768bc5f80667ad82025-08-20T03:11:39ZengUniversidade Federal de GoiásCiência Animal Brasileira1518-27971809-68912025-02-0126Influence of silver nitrate on the mechanical properties of orthopedic bone cement and in vitro antibacterial activityAline Osowski0Sheila Canevese Rahal1Celso Roberto Ribeiro2Luiz Donizete Campeiro Junior3José Ivaldo de Siqueira Silva Júnior4Guilherme Rech Cassanego5Paulo Henrique Gilio Gasparotto6Universidade Estadual Paulista (UNESP), Botucatu, São Paulo, BrasilUniversidade Estadual Paulista (UNESP), Botucatu, São Paulo, BrasilLaboratório de Ensaios Mecânicos e Metalográficos (LEMM), Jaú, São Paulo, BrasilUniversidade Estadual Paulista (UNESP), Botucatu, São Paulo, BrasilUniversidade Estadual Paulista (UNESP), Botucatu, São Paulo, BrasilUniversidade Estadual Paulista (UNESP), Botucatu, São Paulo, BrasilLaboratório de Sanidade Animal - MICROVET, Ji-Paraná, Rondônia, Brasil This study aimed to evaluate the influence of silver nitrate (AgNO3) on the mechanical properties of polymethyl methacrylate (PMMA) bone cement by static testing and in vitro antibacterial activity. Two groups were formed: Group 1, control (n=10); and Group 2, cement with silver nitrate (n=10). In Group 1, the cement was prepared manually by mixing 20 g of PMMA powder with 10 ml of methyl methacrylate liquid. In Group 2, the cement was prepared as in Group 1; however, 0.25 g of silver nitrate was added to 20 g of PMMA powder. No statistical differences were observed for bending strength with (61.80 ± 4.96 MPa) or without silver nitrate (60.20 ± 5.88 MPa). Statistical differences were verified in the higher compressive strength for the control (78.60 ± 3.20 MPa) compared to cement with silver nitrate specimens (74.20 ± 1.61 MPa). Antimicrobial sensitivity testing showed no effect of cement with silver nitrate on Staphylococcus aureus, Streptococcus sp., Pseudomonas aeruginosa, and Escherichia coli. In conclusion, the concentration of silver nitrate did not change the mechanical properties of the PMMA bone cement in the bending test, but it had a negative effect in the compression testing. In addition, the product did not reduce the bacterial load in the in vitro test. https://revistas.ufg.br/vet/article/view/79814 |
| spellingShingle | Aline Osowski Sheila Canevese Rahal Celso Roberto Ribeiro Luiz Donizete Campeiro Junior José Ivaldo de Siqueira Silva Júnior Guilherme Rech Cassanego Paulo Henrique Gilio Gasparotto Influence of silver nitrate on the mechanical properties of orthopedic bone cement and in vitro antibacterial activity Ciência Animal Brasileira |
| title | Influence of silver nitrate on the mechanical properties of orthopedic bone cement and in vitro antibacterial activity |
| title_full | Influence of silver nitrate on the mechanical properties of orthopedic bone cement and in vitro antibacterial activity |
| title_fullStr | Influence of silver nitrate on the mechanical properties of orthopedic bone cement and in vitro antibacterial activity |
| title_full_unstemmed | Influence of silver nitrate on the mechanical properties of orthopedic bone cement and in vitro antibacterial activity |
| title_short | Influence of silver nitrate on the mechanical properties of orthopedic bone cement and in vitro antibacterial activity |
| title_sort | influence of silver nitrate on the mechanical properties of orthopedic bone cement and in vitro antibacterial activity |
| url | https://revistas.ufg.br/vet/article/view/79814 |
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