Synthesis and multifaceted evaluation of novel AgCZ nanocomposite for targeted anti-angiogenic cancer therapy
Abstract Angiogenesis is the formation of blood vessels from the existing vasculature, which is important in the tumor growth where the metastatic spread, of cancer cells depends on an adequate supply of oxygen and nutrients and the removal of waste products. Targeting angiogenesis has emerged as a...
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Nature Portfolio
2024-11-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-76823-x |
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| author | Yasser Hussein Issa Mohammed Ahmed Hassen Shntaif Ahd A. Mansour Samia Alrabghi Saad Alghamdi Naeem F Qusty Mazen Almehmadi Abdulelah Aljuaid Naif Alsiwiehri Mamdouh Allahyani Amirah Albaqami Samiha Salmaoui Sadeq K. Alhag Ahmed M. Senan |
| author_facet | Yasser Hussein Issa Mohammed Ahmed Hassen Shntaif Ahd A. Mansour Samia Alrabghi Saad Alghamdi Naeem F Qusty Mazen Almehmadi Abdulelah Aljuaid Naif Alsiwiehri Mamdouh Allahyani Amirah Albaqami Samiha Salmaoui Sadeq K. Alhag Ahmed M. Senan |
| author_sort | Yasser Hussein Issa Mohammed |
| collection | DOAJ |
| description | Abstract Angiogenesis is the formation of blood vessels from the existing vasculature, which is important in the tumor growth where the metastatic spread, of cancer cells depends on an adequate supply of oxygen and nutrients and the removal of waste products. Targeting angiogenesis has emerged as a promising therapeutic strategy for cancer treatment. This study presents the synthesis and evaluation of a novel Ag-CeO2-ZnO (AgCZ) nanocomposite designed to specifically inhibit angiogenesis for effective cancer therapy. The nanocomposite was synthesized via a glycine-assisted combustion method, and its physicochemical properties were meticulously characterized using advanced analytical techniques. The anti-angiogenesis potential of the AgCZ nanocomposite was vigorously explored through an assortment of in vitro investigations, with a particular interest in inhibiting agents like vascular endothelial growth factor (VEGF). In silico data from molecular docking studies were instrumental in elucidating the nanocomposite’s primary reported mechanism of action, i.e., its strong VEGF target bond. Notably, the nanocomposite had selective cytotoxicity with different types of cancer cells and no sign of serious influence onto normal cells, reflecting great promise of the targeted cancer therapy. Not and importantly, nanocomposite was implemented in vitro studies to measure its anti-angiogenic as well as anti-tumor effect in biological models additionally. Our study highlights emerging developments in medicine and draws possible future paths. The use of AgCZ composite nanoparticle is one of the potential anticancer drug and alternative to the conventional medicine which appears to be safer and more effectual, but further research is needed to overcome current limitations in clinical translation. |
| format | Article |
| id | doaj-art-c317b91dcd69430c8cd8c711217a35e2 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-c317b91dcd69430c8cd8c711217a35e22025-08-20T02:08:19ZengNature PortfolioScientific Reports2045-23222024-11-0114112410.1038/s41598-024-76823-xSynthesis and multifaceted evaluation of novel AgCZ nanocomposite for targeted anti-angiogenic cancer therapyYasser Hussein Issa Mohammed0Ahmed Hassen Shntaif1Ahd A. Mansour2Samia Alrabghi3Saad Alghamdi4Naeem F Qusty5Mazen Almehmadi6Abdulelah Aljuaid7Naif Alsiwiehri8Mamdouh Allahyani9Amirah Albaqami10Samiha Salmaoui11Sadeq K. Alhag12Ahmed M. Senan13Department of Pharmacy, College of Medicine and Health Science , Hajjah UniversityDepartment of Chemistry, College of Science for Women, University of BabylonMedical Laboratory Science Department, Fakeeh College for Medical SciencesExecutive Strategy Administration, Director of Innovation, Makkah Health ClusterDepartment of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura UniversityDepartment of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura UniversityDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif UniversityDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif UniversityDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif UniversityDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif UniversityDepartment of Clinical Laboratory Sciences, Turabah University College, Taif UniversityDepartment of Chemistry, College of Sciences and Arts Turaif, Northern Border, University ArarBiology Department, College of Science and Arts, King Khalid UniversityDepartment of pharmacy, Faculty of medicine and health science, Almahweet UniversityAbstract Angiogenesis is the formation of blood vessels from the existing vasculature, which is important in the tumor growth where the metastatic spread, of cancer cells depends on an adequate supply of oxygen and nutrients and the removal of waste products. Targeting angiogenesis has emerged as a promising therapeutic strategy for cancer treatment. This study presents the synthesis and evaluation of a novel Ag-CeO2-ZnO (AgCZ) nanocomposite designed to specifically inhibit angiogenesis for effective cancer therapy. The nanocomposite was synthesized via a glycine-assisted combustion method, and its physicochemical properties were meticulously characterized using advanced analytical techniques. The anti-angiogenesis potential of the AgCZ nanocomposite was vigorously explored through an assortment of in vitro investigations, with a particular interest in inhibiting agents like vascular endothelial growth factor (VEGF). In silico data from molecular docking studies were instrumental in elucidating the nanocomposite’s primary reported mechanism of action, i.e., its strong VEGF target bond. Notably, the nanocomposite had selective cytotoxicity with different types of cancer cells and no sign of serious influence onto normal cells, reflecting great promise of the targeted cancer therapy. Not and importantly, nanocomposite was implemented in vitro studies to measure its anti-angiogenic as well as anti-tumor effect in biological models additionally. Our study highlights emerging developments in medicine and draws possible future paths. The use of AgCZ composite nanoparticle is one of the potential anticancer drug and alternative to the conventional medicine which appears to be safer and more effectual, but further research is needed to overcome current limitations in clinical translation.https://doi.org/10.1038/s41598-024-76823-xBrand-new nanocompositeCell linesCancer therapyMolecular dockingX-rayVEGF |
| spellingShingle | Yasser Hussein Issa Mohammed Ahmed Hassen Shntaif Ahd A. Mansour Samia Alrabghi Saad Alghamdi Naeem F Qusty Mazen Almehmadi Abdulelah Aljuaid Naif Alsiwiehri Mamdouh Allahyani Amirah Albaqami Samiha Salmaoui Sadeq K. Alhag Ahmed M. Senan Synthesis and multifaceted evaluation of novel AgCZ nanocomposite for targeted anti-angiogenic cancer therapy Scientific Reports Brand-new nanocomposite Cell lines Cancer therapy Molecular docking X-ray VEGF |
| title | Synthesis and multifaceted evaluation of novel AgCZ nanocomposite for targeted anti-angiogenic cancer therapy |
| title_full | Synthesis and multifaceted evaluation of novel AgCZ nanocomposite for targeted anti-angiogenic cancer therapy |
| title_fullStr | Synthesis and multifaceted evaluation of novel AgCZ nanocomposite for targeted anti-angiogenic cancer therapy |
| title_full_unstemmed | Synthesis and multifaceted evaluation of novel AgCZ nanocomposite for targeted anti-angiogenic cancer therapy |
| title_short | Synthesis and multifaceted evaluation of novel AgCZ nanocomposite for targeted anti-angiogenic cancer therapy |
| title_sort | synthesis and multifaceted evaluation of novel agcz nanocomposite for targeted anti angiogenic cancer therapy |
| topic | Brand-new nanocomposite Cell lines Cancer therapy Molecular docking X-ray VEGF |
| url | https://doi.org/10.1038/s41598-024-76823-x |
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