A pyrimidine metabolism-related gene signature for prognosis prediction and immune microenvironment description of breast cancer

A pyrimidine metabolism-related gene signature for prognosis prediction and immune microenvironment description of breast cancer

Abstract Background Metabolic reprogramming is a hallmark in cancer. Pyrimidine metabolism (PM), a part of nucleotide metabolism, has been shown to be associated with the progression of various cancers, and the prognostic predictive ability of pyrimidine metabolism-related genes (PMG) in breast canc...

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Bibliographic Details
Main Authors: Han Wang, Ziling Zhou, Hanyi Zhong, Shoutang Wang, Kunwei Shen, Renhong Huang, Ruo Wang, Zheng Wang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Translational Medicine
Subjects:
Pyrimidine metabolism
Gene signature
Breast cancer
POLR2C
Online Access:https://doi.org/10.1186/s12967-025-06700-2
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