Effectiveness and Safety of Hair Growth Formulation Containing L.f (Teak) Leaf Extract: A Randomized, Double-Blind, Placebo-Controlled Study on Males with Androgenic Alopecia
Background Androgenic alopecia (AGA) is commonly known as male patterned baldness. A high level of dihydrotestosterone (DHT) plays a significant role in AGA development. Inhibition of the enzyme steroid 5-alpha reductase (S5AR), responsible for converting testosterone into DHT, has been shown to del...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-10-01
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| Series: | Journal of Evidence-Based Integrative Medicine |
| Online Access: | https://doi.org/10.1177/2515690X241291141 |
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| author | Nutchaninad Tanuphol B.ATM Neti Waranuch PhD Vanuchawan Wisuitiprot PhD Wudtichai Wisuitiprot PhD Kamonlak Insumrong PhD Prapapan Temkitthawon PhD Nungruthai Suphrom PhD Katechan Jampachaisri PhD Corine Girard PhD Kornkanok Ingkaninan PhD |
| author_facet | Nutchaninad Tanuphol B.ATM Neti Waranuch PhD Vanuchawan Wisuitiprot PhD Wudtichai Wisuitiprot PhD Kamonlak Insumrong PhD Prapapan Temkitthawon PhD Nungruthai Suphrom PhD Katechan Jampachaisri PhD Corine Girard PhD Kornkanok Ingkaninan PhD |
| author_sort | Nutchaninad Tanuphol B.ATM |
| collection | DOAJ |
| description | Background Androgenic alopecia (AGA) is commonly known as male patterned baldness. A high level of dihydrotestosterone (DHT) plays a significant role in AGA development. Inhibition of the enzyme steroid 5-alpha reductase (S5AR), responsible for converting testosterone into DHT, has been shown to delay the progression of AGA. Teak ( Tectona grandis L.f) leaf extract exhibited a potent S5AR inhibitory activity. To prove the effectiveness and safety of teak leaf extract as a hair growth promotor, a double-blind, randomized placebo-controlled trial was conducted. Methods Eighty-one AGA subjects were randomly assigned to receive either a hair tonic containing 1% teak leaf extract (HT-teak), 5%minoxidil (positive control), or a placebo administered twice daily, for 24 weeks. Efficacy was assessed through target area hair count (TAHC), anagen-to-telogen ratio (A/T), hair shedding every 4 weeks, and patients’ subjective assessments of hair regrowth were assessed at the end of the experiment. Data was analyzed using repeated measure ANOVA. Results Both the HT-teak and minoxidil groups exhibited a significant increase in TAHC and A/T, along with a decrease in hair shedding compared to baseline values. Conversely, the placebo group showed no observable signs of hair regrowth. Furthermore, the HT-teak group reported the highest satisfaction scores, and there were no indications of skin irritation or systemic effects on sexual dysfunction and palpitation after 24 weeks of HT-teak application. Conclusion Teak leaf extract, as incorporated in HT-teak, demonstrates potential as an alternative mild hair growth promoter for individuals with AGA, offering both efficacy and safety. Trial registration This study was retrospectively registered on International Standard Randomised Controlled Trial Number (ISRCTN.com); ISRCTN24541842 (registered on January 8, 2024). |
| format | Article |
| id | doaj-art-c313a0612d384bd190fa9f19ed305527 |
| institution | Kabale University |
| issn | 2515-690X |
| language | English |
| publishDate | 2024-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Evidence-Based Integrative Medicine |
| spelling | doaj-art-c313a0612d384bd190fa9f19ed3055272025-01-15T06:03:26ZengSAGE PublishingJournal of Evidence-Based Integrative Medicine2515-690X2024-10-012910.1177/2515690X241291141Effectiveness and Safety of Hair Growth Formulation Containing L.f (Teak) Leaf Extract: A Randomized, Double-Blind, Placebo-Controlled Study on Males with Androgenic AlopeciaNutchaninad Tanuphol B.ATM0Neti Waranuch PhD1Vanuchawan Wisuitiprot PhD2Wudtichai Wisuitiprot PhD3Kamonlak Insumrong PhD4Prapapan Temkitthawon PhD5Nungruthai Suphrom PhD6Katechan Jampachaisri PhD7Corine Girard PhD8Kornkanok Ingkaninan PhD9 Center of Excellence for Natural Health Product Innovation, Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand Cosmetics and Natural Products Research Center, Faculty of Pharmaceutical Sciences, , Phitsanulok, Thailand Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, , Phitsanulok, Thailand Department of Thai Traditional Medicine, , Phitsanulok, Thailand Department of Chemistry, Faculty of Sciences, , Phitsanulok, Thailand Center of Excellence for Natural Health Product Innovation, Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand Department of Chemistry, Faculty of Sciences, , Phitsanulok, Thailand Department of Mathematics, Faculty of Sciences, , Phitsanulok, Thailand Université de Franche-Comté, EFS, INSERM, UMR RIGHT, F-25000, Besançon, France Center of Excellence for Natural Health Product Innovation, Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, ThailandBackground Androgenic alopecia (AGA) is commonly known as male patterned baldness. A high level of dihydrotestosterone (DHT) plays a significant role in AGA development. Inhibition of the enzyme steroid 5-alpha reductase (S5AR), responsible for converting testosterone into DHT, has been shown to delay the progression of AGA. Teak ( Tectona grandis L.f) leaf extract exhibited a potent S5AR inhibitory activity. To prove the effectiveness and safety of teak leaf extract as a hair growth promotor, a double-blind, randomized placebo-controlled trial was conducted. Methods Eighty-one AGA subjects were randomly assigned to receive either a hair tonic containing 1% teak leaf extract (HT-teak), 5%minoxidil (positive control), or a placebo administered twice daily, for 24 weeks. Efficacy was assessed through target area hair count (TAHC), anagen-to-telogen ratio (A/T), hair shedding every 4 weeks, and patients’ subjective assessments of hair regrowth were assessed at the end of the experiment. Data was analyzed using repeated measure ANOVA. Results Both the HT-teak and minoxidil groups exhibited a significant increase in TAHC and A/T, along with a decrease in hair shedding compared to baseline values. Conversely, the placebo group showed no observable signs of hair regrowth. Furthermore, the HT-teak group reported the highest satisfaction scores, and there were no indications of skin irritation or systemic effects on sexual dysfunction and palpitation after 24 weeks of HT-teak application. Conclusion Teak leaf extract, as incorporated in HT-teak, demonstrates potential as an alternative mild hair growth promoter for individuals with AGA, offering both efficacy and safety. Trial registration This study was retrospectively registered on International Standard Randomised Controlled Trial Number (ISRCTN.com); ISRCTN24541842 (registered on January 8, 2024).https://doi.org/10.1177/2515690X241291141 |
| spellingShingle | Nutchaninad Tanuphol B.ATM Neti Waranuch PhD Vanuchawan Wisuitiprot PhD Wudtichai Wisuitiprot PhD Kamonlak Insumrong PhD Prapapan Temkitthawon PhD Nungruthai Suphrom PhD Katechan Jampachaisri PhD Corine Girard PhD Kornkanok Ingkaninan PhD Effectiveness and Safety of Hair Growth Formulation Containing L.f (Teak) Leaf Extract: A Randomized, Double-Blind, Placebo-Controlled Study on Males with Androgenic Alopecia Journal of Evidence-Based Integrative Medicine |
| title | Effectiveness and Safety of Hair Growth Formulation Containing L.f (Teak) Leaf Extract: A Randomized, Double-Blind, Placebo-Controlled Study on Males with Androgenic Alopecia |
| title_full | Effectiveness and Safety of Hair Growth Formulation Containing L.f (Teak) Leaf Extract: A Randomized, Double-Blind, Placebo-Controlled Study on Males with Androgenic Alopecia |
| title_fullStr | Effectiveness and Safety of Hair Growth Formulation Containing L.f (Teak) Leaf Extract: A Randomized, Double-Blind, Placebo-Controlled Study on Males with Androgenic Alopecia |
| title_full_unstemmed | Effectiveness and Safety of Hair Growth Formulation Containing L.f (Teak) Leaf Extract: A Randomized, Double-Blind, Placebo-Controlled Study on Males with Androgenic Alopecia |
| title_short | Effectiveness and Safety of Hair Growth Formulation Containing L.f (Teak) Leaf Extract: A Randomized, Double-Blind, Placebo-Controlled Study on Males with Androgenic Alopecia |
| title_sort | effectiveness and safety of hair growth formulation containing l f teak leaf extract a randomized double blind placebo controlled study on males with androgenic alopecia |
| url | https://doi.org/10.1177/2515690X241291141 |
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