MBL2 Genotypes and Their Associations with MBL Levels and NICU Morbidity in a Cohort of Greek Neonates
The objective of this study was to assess the frequency of MBL2 genotypes and their associations with MBL levels and various morbidities of a neonatal intensive care unit (NICU). One hundred and thirty-four (134) NICU (83 term and 51 preterm) and 150 healthy neonates were enrolled in the study. MBL2...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/478412 |
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| author | Matthaios Speletas Antonios Gounaris Eirini Sevdali Maria Kompoti Katerina Konstantinidi Rozeta Sokou Elena Tsitsami Anastasios E. Germenis |
| author_facet | Matthaios Speletas Antonios Gounaris Eirini Sevdali Maria Kompoti Katerina Konstantinidi Rozeta Sokou Elena Tsitsami Anastasios E. Germenis |
| author_sort | Matthaios Speletas |
| collection | DOAJ |
| description | The objective of this study was to assess the frequency of MBL2 genotypes and their associations with MBL levels and various morbidities of a neonatal intensive care unit (NICU). One hundred and thirty-four (134) NICU (83 term and 51 preterm) and 150 healthy neonates were enrolled in the study. MBL2 genotype and MBL serum levels at birth were determined prospectively by PCR-RFLP-sequencing and enzyme-linked immunosorbent assay, respectively. NICU neonates displayed significantly lower MBL serum levels compared to healthy ones. MBL deficiency, defined as the low MBL2 expression group (XA/O and O/O), was significantly associated with an increased risk of respiratory morbidity, especially transient tachypnea of the newborn and respiratory distress syndrome (RDS). Moreover, an increase of 100 ng/mL of serum MBL levels decreases by 5% the risk of total respiratory morbidity and by 7% the risk of RDS, after correction for prematurity and sex and regardless of the presence of infections. Our study further supports the notion that neonates with MBL deficiency and low MBL serum levels at birth may be at higher risk of developing severe respiratory complications. |
| format | Article |
| id | doaj-art-c310ff8633394808b5f3dba18e129ece |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-c310ff8633394808b5f3dba18e129ece2025-08-20T02:19:01ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/478412478412MBL2 Genotypes and Their Associations with MBL Levels and NICU Morbidity in a Cohort of Greek NeonatesMatthaios Speletas0Antonios Gounaris1Eirini Sevdali2Maria Kompoti3Katerina Konstantinidi4Rozeta Sokou5Elena Tsitsami6Anastasios E. Germenis7Department of Immunology & Histocompatibility, School of Health Sciences, Faculty of Medicine, University Hospital of Larissa, University of Thessaly, Biopolis 3, 41500 Larissa, GreeceNeonatal Intensive Care Unit, School of Health Sciences, Faculty of Medicine, University Hospital of Larissa, University of Thessaly, Biopolis 3, 41500 Larissa, GreeceDepartment of Immunology & Histocompatibility, School of Health Sciences, Faculty of Medicine, University Hospital of Larissa, University of Thessaly, Biopolis 3, 41500 Larissa, GreeceIntensive Care Unit, Thriassion General Hospital of Eleusis, 19600 Athens, GreeceNeonatal Intensive Care Unit, General Hospital of Nikea “Agios Panteleimon”, 11634 Athens, GreeceNeonatal Intensive Care Unit, General Hospital of Nikea “Agios Panteleimon”, 11634 Athens, GreeceDepartment of Immunology & Histocompatibility, School of Health Sciences, Faculty of Medicine, University Hospital of Larissa, University of Thessaly, Biopolis 3, 41500 Larissa, GreeceDepartment of Immunology & Histocompatibility, School of Health Sciences, Faculty of Medicine, University Hospital of Larissa, University of Thessaly, Biopolis 3, 41500 Larissa, GreeceThe objective of this study was to assess the frequency of MBL2 genotypes and their associations with MBL levels and various morbidities of a neonatal intensive care unit (NICU). One hundred and thirty-four (134) NICU (83 term and 51 preterm) and 150 healthy neonates were enrolled in the study. MBL2 genotype and MBL serum levels at birth were determined prospectively by PCR-RFLP-sequencing and enzyme-linked immunosorbent assay, respectively. NICU neonates displayed significantly lower MBL serum levels compared to healthy ones. MBL deficiency, defined as the low MBL2 expression group (XA/O and O/O), was significantly associated with an increased risk of respiratory morbidity, especially transient tachypnea of the newborn and respiratory distress syndrome (RDS). Moreover, an increase of 100 ng/mL of serum MBL levels decreases by 5% the risk of total respiratory morbidity and by 7% the risk of RDS, after correction for prematurity and sex and regardless of the presence of infections. Our study further supports the notion that neonates with MBL deficiency and low MBL serum levels at birth may be at higher risk of developing severe respiratory complications.http://dx.doi.org/10.1155/2015/478412 |
| spellingShingle | Matthaios Speletas Antonios Gounaris Eirini Sevdali Maria Kompoti Katerina Konstantinidi Rozeta Sokou Elena Tsitsami Anastasios E. Germenis MBL2 Genotypes and Their Associations with MBL Levels and NICU Morbidity in a Cohort of Greek Neonates Journal of Immunology Research |
| title | MBL2 Genotypes and Their Associations with MBL Levels and NICU Morbidity in a Cohort of Greek Neonates |
| title_full | MBL2 Genotypes and Their Associations with MBL Levels and NICU Morbidity in a Cohort of Greek Neonates |
| title_fullStr | MBL2 Genotypes and Their Associations with MBL Levels and NICU Morbidity in a Cohort of Greek Neonates |
| title_full_unstemmed | MBL2 Genotypes and Their Associations with MBL Levels and NICU Morbidity in a Cohort of Greek Neonates |
| title_short | MBL2 Genotypes and Their Associations with MBL Levels and NICU Morbidity in a Cohort of Greek Neonates |
| title_sort | mbl2 genotypes and their associations with mbl levels and nicu morbidity in a cohort of greek neonates |
| url | http://dx.doi.org/10.1155/2015/478412 |
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