Cuproplasia and cuproptosis, two sides of the coin
Abstract Copper is an essential micronutrient in the human body, mainly acting as a crucial cofactor required for a wide range of physiological processes across nearly all cell types. Recent advances revealed that tumor cells seize copper to fulfill their rapid proliferation, metastasis, immune evas...
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| Format: | Article |
| Language: | English |
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Wiley
2025-05-01
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| Series: | Cancer Communications |
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| Online Access: | https://doi.org/10.1002/cac2.70001 |
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| author | Kaizhong Lu Chandra Sugiarto Wijaya Qinghua Yao Hongchuan Jin Lifeng Feng |
| author_facet | Kaizhong Lu Chandra Sugiarto Wijaya Qinghua Yao Hongchuan Jin Lifeng Feng |
| author_sort | Kaizhong Lu |
| collection | DOAJ |
| description | Abstract Copper is an essential micronutrient in the human body, mainly acting as a crucial cofactor required for a wide range of physiological processes across nearly all cell types. Recent advances revealed that tumor cells seize copper to fulfill their rapid proliferation, metastasis, immune evasion, and so on by reprogramming the copper regulatory network, defined as cuproplasia. Thus, targeting copper chelation to reduce copper levels has been considered a rational tumor therapy strategy. However, overloaded copper ions could be toxic, which leads to the aggregation of lipoylated mitochondrial proteins and the depletion of iron‐sulfur clusters, ultimately resulting in cell death, termed cuproptosis. Upon its discovery, cuproptosis has attracted great interest from oncologists, and targeting cuproptosis by copper ionophores exhibits as a potential anti‐tumor therapy. In this review, we present the underlying mechanisms involved in cuproplasia and cuproptosis. Additionally, we sum up the chemicals targeting either cuproplasia or cuproptosis for cancer therapy. Further attention should be paid to distinguishing cancer patients who are suitable for targeting cuproplasia or cuproptosis. |
| format | Article |
| id | doaj-art-c30b67d364254c82a46d6b41b269ccbc |
| institution | OA Journals |
| issn | 2523-3548 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Communications |
| spelling | doaj-art-c30b67d364254c82a46d6b41b269ccbc2025-08-20T02:15:19ZengWileyCancer Communications2523-35482025-05-0145550552410.1002/cac2.70001Cuproplasia and cuproptosis, two sides of the coinKaizhong Lu0Chandra Sugiarto Wijaya1Qinghua Yao2Hongchuan Jin3Lifeng Feng4Department of Medical OncologyZhejiang Key Laboratory of Multi‐omics Precision Diagnosis and Treatment of Liver DiseasesCancer Center of Zhejiang UniversitySir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiangP. R. ChinaDepartment of Medical OncologyZhejiang Key Laboratory of Multi‐omics Precision Diagnosis and Treatment of Liver DiseasesCancer Center of Zhejiang UniversitySir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiangP. R. ChinaDepartment of OncologyThe Second Affiliated Hospital of Zhejiang Chinese Medical UniversityXinhua Hospital of Zhejiang ProvinceHangzhouZhejiangP. R. ChinaDepartment of Medical OncologyZhejiang Key Laboratory of Multi‐omics Precision Diagnosis and Treatment of Liver DiseasesCancer Center of Zhejiang UniversitySir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiangP. R. ChinaDepartment of Medical OncologyZhejiang Key Laboratory of Multi‐omics Precision Diagnosis and Treatment of Liver DiseasesCancer Center of Zhejiang UniversitySir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiangP. R. ChinaAbstract Copper is an essential micronutrient in the human body, mainly acting as a crucial cofactor required for a wide range of physiological processes across nearly all cell types. Recent advances revealed that tumor cells seize copper to fulfill their rapid proliferation, metastasis, immune evasion, and so on by reprogramming the copper regulatory network, defined as cuproplasia. Thus, targeting copper chelation to reduce copper levels has been considered a rational tumor therapy strategy. However, overloaded copper ions could be toxic, which leads to the aggregation of lipoylated mitochondrial proteins and the depletion of iron‐sulfur clusters, ultimately resulting in cell death, termed cuproptosis. Upon its discovery, cuproptosis has attracted great interest from oncologists, and targeting cuproptosis by copper ionophores exhibits as a potential anti‐tumor therapy. In this review, we present the underlying mechanisms involved in cuproplasia and cuproptosis. Additionally, we sum up the chemicals targeting either cuproplasia or cuproptosis for cancer therapy. Further attention should be paid to distinguishing cancer patients who are suitable for targeting cuproplasia or cuproptosis.https://doi.org/10.1002/cac2.70001copper homeostasiscuproplasiacuproptosistumortherapeutics targeting copper |
| spellingShingle | Kaizhong Lu Chandra Sugiarto Wijaya Qinghua Yao Hongchuan Jin Lifeng Feng Cuproplasia and cuproptosis, two sides of the coin Cancer Communications copper homeostasis cuproplasia cuproptosis tumor therapeutics targeting copper |
| title | Cuproplasia and cuproptosis, two sides of the coin |
| title_full | Cuproplasia and cuproptosis, two sides of the coin |
| title_fullStr | Cuproplasia and cuproptosis, two sides of the coin |
| title_full_unstemmed | Cuproplasia and cuproptosis, two sides of the coin |
| title_short | Cuproplasia and cuproptosis, two sides of the coin |
| title_sort | cuproplasia and cuproptosis two sides of the coin |
| topic | copper homeostasis cuproplasia cuproptosis tumor therapeutics targeting copper |
| url | https://doi.org/10.1002/cac2.70001 |
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