Fe<sub>3</sub>O<sub>4</sub>@β-cyclodextrin Nanosystem: A Promising Adjuvant Approach in Cancer Treatment
The high incidence of melanoma leading to a poor prognosis rate endorses the development of alternative and innovative approaches in the treatment of melanoma. Therefore, the present study aims to develop and characterize, in terms of physicochemical features and biological impact, an aqueous suspen...
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MDPI AG
2025-08-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/15/15/1192 |
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| author | Claudia Geanina Watz Ciprian-Valentin Mihali Camelia Oprean Lavinia Krauss Maldea Calin Adrian Tatu Mirela Nicolov Ioan-Ovidiu Sîrbu Cristina A. Dehelean Vlad Socoliuc Elena-Alina Moacă |
| author_facet | Claudia Geanina Watz Ciprian-Valentin Mihali Camelia Oprean Lavinia Krauss Maldea Calin Adrian Tatu Mirela Nicolov Ioan-Ovidiu Sîrbu Cristina A. Dehelean Vlad Socoliuc Elena-Alina Moacă |
| author_sort | Claudia Geanina Watz |
| collection | DOAJ |
| description | The high incidence of melanoma leading to a poor prognosis rate endorses the development of alternative and innovative approaches in the treatment of melanoma. Therefore, the present study aims to develop and characterize, in terms of physicochemical features and biological impact, an aqueous suspension of magnetite (Fe<sub>3</sub>O<sub>4</sub>) coated with β-cyclodextrin (Fe<sub>3</sub>O<sub>4</sub>@β-CD) as a potential innovative alternative nanosystem for melanoma therapy. The nanosystem exhibited physicochemical characteristics suitable for biological applications, revealing a successful complexation of Fe<sub>3</sub>O<sub>4</sub> NPs with β-CD and an average size of 18.1 ± 2.1 nm. In addition, the in vitro evaluations revealed that the newly developed nanosystem presented high biocompatibility on a human keratinocyte (HaCaT) monolayer and selective antiproliferative activity on amelanotic human melanoma (A375) cells, inducing early apoptosis features when concentrations of 10, 15, and 20 μg/mL were employed for 48 h and 72 h. Collectively, the Fe<sub>3</sub>O<sub>4</sub>@β-CD nanosystem reveals promising features for an adjuvant approach in melanoma treatment, mainly due to its β-cyclodextrin coating, thus endorsing a potential co-loading of therapeutic drugs. Furthermore, the intrinsic magnetic core of Fe<sub>3</sub>O<sub>4</sub> NPs supports the magnetically based cancer treatment strategies. |
| format | Article |
| id | doaj-art-c30a4cb3305a49809d5a7c4f492ebda8 |
| institution | Kabale University |
| issn | 2079-4991 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj-art-c30a4cb3305a49809d5a7c4f492ebda82025-08-20T04:00:54ZengMDPI AGNanomaterials2079-49912025-08-011515119210.3390/nano15151192Fe<sub>3</sub>O<sub>4</sub>@β-cyclodextrin Nanosystem: A Promising Adjuvant Approach in Cancer TreatmentClaudia Geanina Watz0Ciprian-Valentin Mihali1Camelia Oprean2Lavinia Krauss Maldea3Calin Adrian Tatu4Mirela Nicolov5Ioan-Ovidiu Sîrbu6Cristina A. Dehelean7Vlad Socoliuc8Elena-Alina Moacă9Department of Pharmaceutical Physics, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDepartment of Life Sciences, Faculty of Medicine, Vasile Goldis Western University of Arad, 86 No., Liviu Rebreanu St., 310414 Arad, RomaniaCenter for Drug Data Analysis, Cheminformatics and the Internet of Medical Things, ”Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDepartment of Pharmaceutical Physics, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaOncoGen Center for Gene and Cellular Therapies in the Treatment of Cancer, “Pius Brînzeu” County Clinical Emergency Hospital, Timișoara, Blvd. Liviu Rebreanu 156, 300723 Timisoara, RomaniaDepartment of Pharmaceutical Physics, Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDepartment of Biochemistry, Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy Timisoara, 300041 Timisoara, RomaniaResearch Center for Pharmaco-Toxicological Evaluation, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaLaboratory of Magnetic Fluids, Center for Fundamental and Advanced Technical Research (CFATR), Romanian Academy—Timisoara Branch, 24 No., Mihai Viteazul Ave., 300223 Timisoara, RomaniaResearch Center for Pharmaco-Toxicological Evaluation, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaThe high incidence of melanoma leading to a poor prognosis rate endorses the development of alternative and innovative approaches in the treatment of melanoma. Therefore, the present study aims to develop and characterize, in terms of physicochemical features and biological impact, an aqueous suspension of magnetite (Fe<sub>3</sub>O<sub>4</sub>) coated with β-cyclodextrin (Fe<sub>3</sub>O<sub>4</sub>@β-CD) as a potential innovative alternative nanosystem for melanoma therapy. The nanosystem exhibited physicochemical characteristics suitable for biological applications, revealing a successful complexation of Fe<sub>3</sub>O<sub>4</sub> NPs with β-CD and an average size of 18.1 ± 2.1 nm. In addition, the in vitro evaluations revealed that the newly developed nanosystem presented high biocompatibility on a human keratinocyte (HaCaT) monolayer and selective antiproliferative activity on amelanotic human melanoma (A375) cells, inducing early apoptosis features when concentrations of 10, 15, and 20 μg/mL were employed for 48 h and 72 h. Collectively, the Fe<sub>3</sub>O<sub>4</sub>@β-CD nanosystem reveals promising features for an adjuvant approach in melanoma treatment, mainly due to its β-cyclodextrin coating, thus endorsing a potential co-loading of therapeutic drugs. Furthermore, the intrinsic magnetic core of Fe<sub>3</sub>O<sub>4</sub> NPs supports the magnetically based cancer treatment strategies.https://www.mdpi.com/2079-4991/15/15/1192Fe<sub>3</sub>O<sub>4</sub>@β-CDHaCaTA375adjuvant cancer therapy |
| spellingShingle | Claudia Geanina Watz Ciprian-Valentin Mihali Camelia Oprean Lavinia Krauss Maldea Calin Adrian Tatu Mirela Nicolov Ioan-Ovidiu Sîrbu Cristina A. Dehelean Vlad Socoliuc Elena-Alina Moacă Fe<sub>3</sub>O<sub>4</sub>@β-cyclodextrin Nanosystem: A Promising Adjuvant Approach in Cancer Treatment Nanomaterials Fe<sub>3</sub>O<sub>4</sub>@β-CD HaCaT A375 adjuvant cancer therapy |
| title | Fe<sub>3</sub>O<sub>4</sub>@β-cyclodextrin Nanosystem: A Promising Adjuvant Approach in Cancer Treatment |
| title_full | Fe<sub>3</sub>O<sub>4</sub>@β-cyclodextrin Nanosystem: A Promising Adjuvant Approach in Cancer Treatment |
| title_fullStr | Fe<sub>3</sub>O<sub>4</sub>@β-cyclodextrin Nanosystem: A Promising Adjuvant Approach in Cancer Treatment |
| title_full_unstemmed | Fe<sub>3</sub>O<sub>4</sub>@β-cyclodextrin Nanosystem: A Promising Adjuvant Approach in Cancer Treatment |
| title_short | Fe<sub>3</sub>O<sub>4</sub>@β-cyclodextrin Nanosystem: A Promising Adjuvant Approach in Cancer Treatment |
| title_sort | fe sub 3 sub o sub 4 sub β cyclodextrin nanosystem a promising adjuvant approach in cancer treatment |
| topic | Fe<sub>3</sub>O<sub>4</sub>@β-CD HaCaT A375 adjuvant cancer therapy |
| url | https://www.mdpi.com/2079-4991/15/15/1192 |
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