Comparison of vagus nerve cross-sectional area between brain-first and body-first Parkinson’s disease
Abstract The vagus nerve (VN) is the main neural pathway linking the gut and brain in Parkinson’s disease (PD). In this study, we utilized high-resolution ultrasound to measure the VN cross-sectional area (CSA) in 96 healthy controls (HCs) and 75 PD patients. The PD group was further categorized int...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-12-01
|
| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-024-00844-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850169224157200384 |
|---|---|
| author | Shuangshuang Dong Bo Shen Xu Jiang Jun Zhu Haiying Zhang Yang Zhao Yaning Chen Dongfeng Li Yuanyuan Feng Yi Chen Yang Pan Feng Han Ben Liu Li Zhang |
| author_facet | Shuangshuang Dong Bo Shen Xu Jiang Jun Zhu Haiying Zhang Yang Zhao Yaning Chen Dongfeng Li Yuanyuan Feng Yi Chen Yang Pan Feng Han Ben Liu Li Zhang |
| author_sort | Shuangshuang Dong |
| collection | DOAJ |
| description | Abstract The vagus nerve (VN) is the main neural pathway linking the gut and brain in Parkinson’s disease (PD). In this study, we utilized high-resolution ultrasound to measure the VN cross-sectional area (CSA) in 96 healthy controls (HCs) and 75 PD patients. The PD group was further categorized into three subgroups: PD-preRBD, PD-postRBD, and PD-nonRBD. PD-preRBD was the body-first subtype, and PD-postRBD and PD-nonRBD were the brain-first subtype. The PD group had a significantly lower VN CSA than HCs. Subgroup analysis revealed that the PD-preRBD group tended to exhibit a smaller VN CSA than both the PD-postRBD and PD-nonRBD groups. The VN CSA, specifically the right VN, was significantly correlated with the body-first subtype and some components of PD-related assessment scales. Overall, these findings provide evidence of VN atrophy in PD, especially in body-first PD, suggesting that VN ultrasound could serve as an adjunctive diagnostic tool. |
| format | Article |
| id | doaj-art-c2ffae62a28a42b683a23a77b863d6bf |
| institution | OA Journals |
| issn | 2373-8057 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj-art-c2ffae62a28a42b683a23a77b863d6bf2025-08-20T02:20:45ZengNature Portfolionpj Parkinson's Disease2373-80572024-12-011011910.1038/s41531-024-00844-6Comparison of vagus nerve cross-sectional area between brain-first and body-first Parkinson’s diseaseShuangshuang Dong0Bo Shen1Xu Jiang2Jun Zhu3Haiying Zhang4Yang Zhao5Yaning Chen6Dongfeng Li7Yuanyuan Feng8Yi Chen9Yang Pan10Feng Han11Ben Liu12Li Zhang13Department of Geriatric Neurology, Affiliated Brain Hospital of Nanjing Medical UniversityDepartment of Geriatric Neurology, Affiliated Brain Hospital of Nanjing Medical UniversityDepartment of Geriatric Neurology, Affiliated Brain Hospital of Nanjing Medical UniversityDepartment of Geriatric Neurology, Affiliated Brain Hospital of Nanjing Medical UniversityDepartment of Geriatric Neurology, Affiliated Brain Hospital of Nanjing Medical UniversityDepartment of Geriatric Neurology, Affiliated Brain Hospital of Nanjing Medical UniversityDepartment of Geriatric Neurology, Affiliated Brain Hospital of Nanjing Medical UniversityDepartment of Geriatric Neurology, Affiliated Brain Hospital of Nanjing Medical UniversityDepartment of Geriatric Neurology, Affiliated Brain Hospital of Nanjing Medical UniversityDepartment of Geriatric Neurology, Affiliated Brain Hospital of Nanjing Medical UniversityDepartment of Geriatric Neurology, Affiliated Brain Hospital of Nanjing Medical UniversityInternational Joint Laboratory for Drug Target of Critical Illnesses, School of Pharmacy, Nanjing Medical UniversityDepartment of Physical Diagnosis, Affiliated Brain Hospital of Nanjing Medical UniversityDepartment of Geriatric Neurology, Affiliated Brain Hospital of Nanjing Medical UniversityAbstract The vagus nerve (VN) is the main neural pathway linking the gut and brain in Parkinson’s disease (PD). In this study, we utilized high-resolution ultrasound to measure the VN cross-sectional area (CSA) in 96 healthy controls (HCs) and 75 PD patients. The PD group was further categorized into three subgroups: PD-preRBD, PD-postRBD, and PD-nonRBD. PD-preRBD was the body-first subtype, and PD-postRBD and PD-nonRBD were the brain-first subtype. The PD group had a significantly lower VN CSA than HCs. Subgroup analysis revealed that the PD-preRBD group tended to exhibit a smaller VN CSA than both the PD-postRBD and PD-nonRBD groups. The VN CSA, specifically the right VN, was significantly correlated with the body-first subtype and some components of PD-related assessment scales. Overall, these findings provide evidence of VN atrophy in PD, especially in body-first PD, suggesting that VN ultrasound could serve as an adjunctive diagnostic tool.https://doi.org/10.1038/s41531-024-00844-6 |
| spellingShingle | Shuangshuang Dong Bo Shen Xu Jiang Jun Zhu Haiying Zhang Yang Zhao Yaning Chen Dongfeng Li Yuanyuan Feng Yi Chen Yang Pan Feng Han Ben Liu Li Zhang Comparison of vagus nerve cross-sectional area between brain-first and body-first Parkinson’s disease npj Parkinson's Disease |
| title | Comparison of vagus nerve cross-sectional area between brain-first and body-first Parkinson’s disease |
| title_full | Comparison of vagus nerve cross-sectional area between brain-first and body-first Parkinson’s disease |
| title_fullStr | Comparison of vagus nerve cross-sectional area between brain-first and body-first Parkinson’s disease |
| title_full_unstemmed | Comparison of vagus nerve cross-sectional area between brain-first and body-first Parkinson’s disease |
| title_short | Comparison of vagus nerve cross-sectional area between brain-first and body-first Parkinson’s disease |
| title_sort | comparison of vagus nerve cross sectional area between brain first and body first parkinson s disease |
| url | https://doi.org/10.1038/s41531-024-00844-6 |
| work_keys_str_mv | AT shuangshuangdong comparisonofvagusnervecrosssectionalareabetweenbrainfirstandbodyfirstparkinsonsdisease AT boshen comparisonofvagusnervecrosssectionalareabetweenbrainfirstandbodyfirstparkinsonsdisease AT xujiang comparisonofvagusnervecrosssectionalareabetweenbrainfirstandbodyfirstparkinsonsdisease AT junzhu comparisonofvagusnervecrosssectionalareabetweenbrainfirstandbodyfirstparkinsonsdisease AT haiyingzhang comparisonofvagusnervecrosssectionalareabetweenbrainfirstandbodyfirstparkinsonsdisease AT yangzhao comparisonofvagusnervecrosssectionalareabetweenbrainfirstandbodyfirstparkinsonsdisease AT yaningchen comparisonofvagusnervecrosssectionalareabetweenbrainfirstandbodyfirstparkinsonsdisease AT dongfengli comparisonofvagusnervecrosssectionalareabetweenbrainfirstandbodyfirstparkinsonsdisease AT yuanyuanfeng comparisonofvagusnervecrosssectionalareabetweenbrainfirstandbodyfirstparkinsonsdisease AT yichen comparisonofvagusnervecrosssectionalareabetweenbrainfirstandbodyfirstparkinsonsdisease AT yangpan comparisonofvagusnervecrosssectionalareabetweenbrainfirstandbodyfirstparkinsonsdisease AT fenghan comparisonofvagusnervecrosssectionalareabetweenbrainfirstandbodyfirstparkinsonsdisease AT benliu comparisonofvagusnervecrosssectionalareabetweenbrainfirstandbodyfirstparkinsonsdisease AT lizhang comparisonofvagusnervecrosssectionalareabetweenbrainfirstandbodyfirstparkinsonsdisease |