Uveal Melanoma

Uveal melanoma is the most common primary intraocular malignancy and the leading primary intraocular disease which can be fatal in adults. In this paper epidemiologic, pathogenetic, and clinical aspects of uveal melanoma are discussed. Despite the advance in local ocular treatments, there has been n...

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Main Authors: Vasilios P. Papastefanou, Victoria M. L. Cohen
Format: Article
Language:English
Published: Wiley 2011-01-01
Series:Journal of Skin Cancer
Online Access:http://dx.doi.org/10.1155/2011/573974
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author Vasilios P. Papastefanou
Victoria M. L. Cohen
author_facet Vasilios P. Papastefanou
Victoria M. L. Cohen
author_sort Vasilios P. Papastefanou
collection DOAJ
description Uveal melanoma is the most common primary intraocular malignancy and the leading primary intraocular disease which can be fatal in adults. In this paper epidemiologic, pathogenetic, and clinical aspects of uveal melanoma are discussed. Despite the advance in local ocular treatments, there has been no change in patient survival for three decades. Development of metastases affects prognosis significantly. Current survival rates, factors predictive of metastatic potential and metastatic screening algorithms are discussed. Proposed and emerging treatments for uveal melanoma metastases are also overviewed. Current advances in genetics and cytogenetics have provided a significant insight in tumours with high metastatic potential and the molecular mechanisms that underlie their development. Biopsy of those lesions may prove to be important for prognostication and to allow further research into genetic mutations and potential new therapeutic targets in the future.
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institution Kabale University
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publishDate 2011-01-01
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series Journal of Skin Cancer
spelling doaj-art-c2ff89d4c0ab4e36af491f0c91eecf0d2025-02-03T01:11:44ZengWileyJournal of Skin Cancer2090-29052090-29132011-01-01201110.1155/2011/573974573974Uveal MelanomaVasilios P. Papastefanou0Victoria M. L. Cohen1Ocular Oncology Service, Moorfields Eye Hospital, London EC1V 2PD, UKOcular Oncology Service, Moorfields Eye Hospital, London EC1V 2PD, UKUveal melanoma is the most common primary intraocular malignancy and the leading primary intraocular disease which can be fatal in adults. In this paper epidemiologic, pathogenetic, and clinical aspects of uveal melanoma are discussed. Despite the advance in local ocular treatments, there has been no change in patient survival for three decades. Development of metastases affects prognosis significantly. Current survival rates, factors predictive of metastatic potential and metastatic screening algorithms are discussed. Proposed and emerging treatments for uveal melanoma metastases are also overviewed. Current advances in genetics and cytogenetics have provided a significant insight in tumours with high metastatic potential and the molecular mechanisms that underlie their development. Biopsy of those lesions may prove to be important for prognostication and to allow further research into genetic mutations and potential new therapeutic targets in the future.http://dx.doi.org/10.1155/2011/573974
spellingShingle Vasilios P. Papastefanou
Victoria M. L. Cohen
Uveal Melanoma
Journal of Skin Cancer
title Uveal Melanoma
title_full Uveal Melanoma
title_fullStr Uveal Melanoma
title_full_unstemmed Uveal Melanoma
title_short Uveal Melanoma
title_sort uveal melanoma
url http://dx.doi.org/10.1155/2011/573974
work_keys_str_mv AT vasiliosppapastefanou uvealmelanoma
AT victoriamlcohen uvealmelanoma