Successful anti-IL-6 treatment for interstitial lung disease associated with STAT3 gain-of-function: a case report and literature review

Successful anti-IL-6 treatment for interstitial lung disease associated with STAT3 gain-of-function: a case report and literature review

Autosomal dominant gain-of-function (GOF) variants in the signal transducer and activator of transcription 3 (STAT3) result in an inborn error of immunity characterized by multi-organ autoimmunity and lymphoproliferation. In this study, we retrospectively analyzed a rare case of STAT3 GOF mutation w...

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Bibliographic Details
Main Authors: Peng Zhou, Meifang Zhu, Yuting Pan, Jing Jin, Zhidan Fan, Haiguo Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pediatrics
Subjects:
STAT3
gain-of-function
inborn error of immunity
interstitial lung disease
tocilizumab
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2025.1577746/full
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