Reversible Cerebral Vasoconstriction Syndrome Following Blood Transfusion in a Patient With Chronic Anemia: A Case Report
ABSTRACT Reversible cerebral vasoconstriction syndrome (RCVS) is a rare neurological disorder characterized by transient constriction and dilation of cerebral arteries, leading to severe headaches and neurological deficits. This case report describes a 41‐year‐old woman with chronic anemia, acute ch...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-12-01
|
| Series: | Clinical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ccr3.9618 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850105408340885504 |
|---|---|
| author | Amogh Verma Govind Sharma Ajeet Singh Harshit Gupta Deependra Pratap Singh Abhay M. Gaidhane Mahalaqua Nazli Khatib Ganesh Bushi Sanjit Sah Rodrigue Ndabashinze |
| author_facet | Amogh Verma Govind Sharma Ajeet Singh Harshit Gupta Deependra Pratap Singh Abhay M. Gaidhane Mahalaqua Nazli Khatib Ganesh Bushi Sanjit Sah Rodrigue Ndabashinze |
| author_sort | Amogh Verma |
| collection | DOAJ |
| description | ABSTRACT Reversible cerebral vasoconstriction syndrome (RCVS) is a rare neurological disorder characterized by transient constriction and dilation of cerebral arteries, leading to severe headaches and neurological deficits. This case report describes a 41‐year‐old woman with chronic anemia, acute chronic kidney disease, type 2 diabetes mellitus, and rheumatoid arthritis who developed RCVS following transfusion of packed red blood cells (PRBCs). She experienced sudden‐onset seizures and a thunderclap headache 5 days post‐transfusion. Diagnostic imaging, including computed tomography (CT) and magnetic resonance imaging (MRI), revealed the characteristic features of vasogenic edema. The patient was treated with blood pressure control and symptomatic relief for pain, resulting in gradual improvement. This case highlights the importance of recognizing RCVS as a potential complication of blood transfusions, particularly in patients with significant comorbidities. Understanding the possible mechanisms, including rapid hemoglobin correction, and the effects of residual plasma and storage lesions in transfused blood, is essential to prevent and manage this rare but serious condition. |
| format | Article |
| id | doaj-art-c2fbdd97203c4c8fb790ede8ae60318d |
| institution | OA Journals |
| issn | 2050-0904 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj-art-c2fbdd97203c4c8fb790ede8ae60318d2025-08-20T02:39:04ZengWileyClinical Case Reports2050-09042024-12-011212n/an/a10.1002/ccr3.9618Reversible Cerebral Vasoconstriction Syndrome Following Blood Transfusion in a Patient With Chronic Anemia: A Case ReportAmogh Verma0Govind Sharma1Ajeet Singh2Harshit Gupta3Deependra Pratap Singh4Abhay M. Gaidhane5Mahalaqua Nazli Khatib6Ganesh Bushi7Sanjit Sah8Rodrigue Ndabashinze9Department of Internal Medicine Rama Medical College Hospital and Research Center Hapur Uttar Pradesh IndiaDepartment of Radiology Rama Medical College Hospital and Research Center Hapur Uttar Pradesh IndiaDepartment of Internal Medicine Dow University of Health Sciences Karachi PakistanDepartment of Internal Medicine All India Institute of Medical Sciences (AIIMS) Rishikesh Rishikesh IndiaDepartment of Biotechnology Graphic Era Hill University Dehradun IndiaSchool of Epidemiology and Public Health, Jawaharlal Nehru Medical College and Global Health Academy Datta Meghe Institute of Higher Education Wardha IndiaDivision of Evidence Synthesis, Global Consortium of Public Health and Research Datta Meghe Institute of Higher Education Wardha IndiaCenter for Global Health Research Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University Chennai IndiaDr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth Pune Maharashtra IndiaUniversity of Burundi Bujumbura BurundiABSTRACT Reversible cerebral vasoconstriction syndrome (RCVS) is a rare neurological disorder characterized by transient constriction and dilation of cerebral arteries, leading to severe headaches and neurological deficits. This case report describes a 41‐year‐old woman with chronic anemia, acute chronic kidney disease, type 2 diabetes mellitus, and rheumatoid arthritis who developed RCVS following transfusion of packed red blood cells (PRBCs). She experienced sudden‐onset seizures and a thunderclap headache 5 days post‐transfusion. Diagnostic imaging, including computed tomography (CT) and magnetic resonance imaging (MRI), revealed the characteristic features of vasogenic edema. The patient was treated with blood pressure control and symptomatic relief for pain, resulting in gradual improvement. This case highlights the importance of recognizing RCVS as a potential complication of blood transfusions, particularly in patients with significant comorbidities. Understanding the possible mechanisms, including rapid hemoglobin correction, and the effects of residual plasma and storage lesions in transfused blood, is essential to prevent and manage this rare but serious condition.https://doi.org/10.1002/ccr3.9618blood transfusionchronic anemiaRCVSseizuresthunderclap headachevasogenic edema |
| spellingShingle | Amogh Verma Govind Sharma Ajeet Singh Harshit Gupta Deependra Pratap Singh Abhay M. Gaidhane Mahalaqua Nazli Khatib Ganesh Bushi Sanjit Sah Rodrigue Ndabashinze Reversible Cerebral Vasoconstriction Syndrome Following Blood Transfusion in a Patient With Chronic Anemia: A Case Report Clinical Case Reports blood transfusion chronic anemia RCVS seizures thunderclap headache vasogenic edema |
| title | Reversible Cerebral Vasoconstriction Syndrome Following Blood Transfusion in a Patient With Chronic Anemia: A Case Report |
| title_full | Reversible Cerebral Vasoconstriction Syndrome Following Blood Transfusion in a Patient With Chronic Anemia: A Case Report |
| title_fullStr | Reversible Cerebral Vasoconstriction Syndrome Following Blood Transfusion in a Patient With Chronic Anemia: A Case Report |
| title_full_unstemmed | Reversible Cerebral Vasoconstriction Syndrome Following Blood Transfusion in a Patient With Chronic Anemia: A Case Report |
| title_short | Reversible Cerebral Vasoconstriction Syndrome Following Blood Transfusion in a Patient With Chronic Anemia: A Case Report |
| title_sort | reversible cerebral vasoconstriction syndrome following blood transfusion in a patient with chronic anemia a case report |
| topic | blood transfusion chronic anemia RCVS seizures thunderclap headache vasogenic edema |
| url | https://doi.org/10.1002/ccr3.9618 |
| work_keys_str_mv | AT amoghverma reversiblecerebralvasoconstrictionsyndromefollowingbloodtransfusioninapatientwithchronicanemiaacasereport AT govindsharma reversiblecerebralvasoconstrictionsyndromefollowingbloodtransfusioninapatientwithchronicanemiaacasereport AT ajeetsingh reversiblecerebralvasoconstrictionsyndromefollowingbloodtransfusioninapatientwithchronicanemiaacasereport AT harshitgupta reversiblecerebralvasoconstrictionsyndromefollowingbloodtransfusioninapatientwithchronicanemiaacasereport AT deependrapratapsingh reversiblecerebralvasoconstrictionsyndromefollowingbloodtransfusioninapatientwithchronicanemiaacasereport AT abhaymgaidhane reversiblecerebralvasoconstrictionsyndromefollowingbloodtransfusioninapatientwithchronicanemiaacasereport AT mahalaquanazlikhatib reversiblecerebralvasoconstrictionsyndromefollowingbloodtransfusioninapatientwithchronicanemiaacasereport AT ganeshbushi reversiblecerebralvasoconstrictionsyndromefollowingbloodtransfusioninapatientwithchronicanemiaacasereport AT sanjitsah reversiblecerebralvasoconstrictionsyndromefollowingbloodtransfusioninapatientwithchronicanemiaacasereport AT rodriguendabashinze reversiblecerebralvasoconstrictionsyndromefollowingbloodtransfusioninapatientwithchronicanemiaacasereport |