Photochemical Synthesis of the Bioconjugate Folic Acid-Gold Nanoparticles
In this paper we present a rapid and simple onepot method to obtain gold nanoparticles functionalized with folic acid using a photochemistry method. The bioconjugate folic acid-gold nanoparticle was generated in one step using a photo-reduction method, mixing hydrogen tetrachloroaurate with folic ac...
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| Format: | Article |
| Language: | English |
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Wiley
2013-09-01
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| Series: | Nanomaterials and Nanotechnology |
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| Online Access: | http://www.intechopen.com/journals/nanomaterials_and_nanotechnology/photochemical-synthesis-of-the-bioconjugate-folic-acid-gold-nanoparticles |
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| _version_ | 1849685133505855488 |
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| author | John Castillo Linda Bertel Edgar Páez-Mozo Fernando Martínez |
| author_facet | John Castillo Linda Bertel Edgar Páez-Mozo Fernando Martínez |
| author_sort | John Castillo |
| collection | DOAJ |
| description | In this paper we present a rapid and simple onepot
method to obtain gold nanoparticles functionalized
with folic acid using a photochemistry method. The
bioconjugate folic acid-gold nanoparticle was generated
in one step using a photo-reduction method, mixing
hydrogen tetrachloroaurate with folic acid in different
ratios and varying the illumination time of a mercury
lamp (λ= 255 nm). Scanning electron microscopy showed
a particle size of around 40-50nm and dynamic light
scattering exhibited that the zeta potential varies from -41
to -50mV with different illumination times. Storage in the
dark at 4°C prolongs the stability of folic acid-gold
nanoparticle suspensions to up to 26 days. Ultraviolet
visible and Fourier transform infrared spectroscopy
showed a surface plasmon band of around 534nm and
fluorescence spectroscopy exhibited a quenching effect on
gold nanoparticles in the fluorescence emission of folic
acid and thus confirmed the conjugation of folic acid to
the surface of gold nanoparticles. In this study we
demonstrate the use of a photochemistry method to
obtain folic acid-gold nanoparticles in a simple and rapid
way without the use of surfactants and long reaction
times. The photochemical synthesis of FA-AuNPs opens
new perspectives for creating novel functional
nanomaterials for biomedical applications. |
| format | Article |
| id | doaj-art-c2f8fc4ea19c4dc5bb6de92cfbce4cf4 |
| institution | DOAJ |
| issn | 1847-9804 |
| language | English |
| publishDate | 2013-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Nanomaterials and Nanotechnology |
| spelling | doaj-art-c2f8fc4ea19c4dc5bb6de92cfbce4cf42025-08-20T03:23:15ZengWileyNanomaterials and Nanotechnology1847-98042013-09-01318http://dx.doi.org/10.5772/5714445686Photochemical Synthesis of the Bioconjugate Folic Acid-Gold NanoparticlesJohn CastilloLinda BertelEdgar Páez-MozoFernando MartínezIn this paper we present a rapid and simple onepot method to obtain gold nanoparticles functionalized with folic acid using a photochemistry method. The bioconjugate folic acid-gold nanoparticle was generated in one step using a photo-reduction method, mixing hydrogen tetrachloroaurate with folic acid in different ratios and varying the illumination time of a mercury lamp (λ= 255 nm). Scanning electron microscopy showed a particle size of around 40-50nm and dynamic light scattering exhibited that the zeta potential varies from -41 to -50mV with different illumination times. Storage in the dark at 4°C prolongs the stability of folic acid-gold nanoparticle suspensions to up to 26 days. Ultraviolet visible and Fourier transform infrared spectroscopy showed a surface plasmon band of around 534nm and fluorescence spectroscopy exhibited a quenching effect on gold nanoparticles in the fluorescence emission of folic acid and thus confirmed the conjugation of folic acid to the surface of gold nanoparticles. In this study we demonstrate the use of a photochemistry method to obtain folic acid-gold nanoparticles in a simple and rapid way without the use of surfactants and long reaction times. The photochemical synthesis of FA-AuNPs opens new perspectives for creating novel functional nanomaterials for biomedical applications.http://www.intechopen.com/journals/nanomaterials_and_nanotechnology/photochemical-synthesis-of-the-bioconjugate-folic-acid-gold-nanoparticlesPhotochemical SynthesisGold NanoparticlesFolic Acid |
| spellingShingle | John Castillo Linda Bertel Edgar Páez-Mozo Fernando Martínez Photochemical Synthesis of the Bioconjugate Folic Acid-Gold Nanoparticles Nanomaterials and Nanotechnology Photochemical Synthesis Gold Nanoparticles Folic Acid |
| title | Photochemical Synthesis of the Bioconjugate Folic Acid-Gold Nanoparticles |
| title_full | Photochemical Synthesis of the Bioconjugate Folic Acid-Gold Nanoparticles |
| title_fullStr | Photochemical Synthesis of the Bioconjugate Folic Acid-Gold Nanoparticles |
| title_full_unstemmed | Photochemical Synthesis of the Bioconjugate Folic Acid-Gold Nanoparticles |
| title_short | Photochemical Synthesis of the Bioconjugate Folic Acid-Gold Nanoparticles |
| title_sort | photochemical synthesis of the bioconjugate folic acid gold nanoparticles |
| topic | Photochemical Synthesis Gold Nanoparticles Folic Acid |
| url | http://www.intechopen.com/journals/nanomaterials_and_nanotechnology/photochemical-synthesis-of-the-bioconjugate-folic-acid-gold-nanoparticles |
| work_keys_str_mv | AT johncastillo photochemicalsynthesisofthebioconjugatefolicacidgoldnanoparticles AT lindabertel photochemicalsynthesisofthebioconjugatefolicacidgoldnanoparticles AT edgarpaezmozo photochemicalsynthesisofthebioconjugatefolicacidgoldnanoparticles AT fernandomartinez photochemicalsynthesisofthebioconjugatefolicacidgoldnanoparticles |