Nanoparticles with curcumin and piperine modulate steroid biosynthesis in prostate cancer

Nanoparticles with curcumin and piperine modulate steroid biosynthesis in prostate cancer

Abstract Endogenous androgens are pivotal in the development and progression of prostate cancer (PC). We investigated nanoparticle formulations of curcumin and piperine in modulating steroidogenesis within PC cells. Using multiple PC cell lines (LNCaP, VCaP, DU145 and PC3) we studied the effects of...

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Bibliographic Details
Main Authors: Jibira Yakubu, Evangelos Natsaridis, Therina du Toit, Isabel Sousa Barata, Oya Tagit, Amit V. Pandey
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Steroidogenesis
CYP17A1
Prostate cancer
Curcumin nanoparticles
Androgen synthesis
Nanoparticle formulations
Online Access:https://doi.org/10.1038/s41598-025-98102-z
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