The Effect of Liberica Coffee on Liver Physiology and Histological Appearance of White Mice
Indonesia is one of the world's top coffee producing and exporting countries. Liberica coffee was one of the most widely cultivated types of coffee in Indonesia, especially in Tanjung Jabung Barat Jambi Province. Liberica coffee known as the coffee with highest levels of caffeine if compared wi...
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Indonesian Society for Cancer Chemoprevention
2018-10-01
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| Series: | ISCC (Indonesian Journal of Cancer Chemoprevention) |
| Online Access: | https://ijcc.chemoprev.org/index.php/ijcc/article/view/247 |
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| author | Cindra Ayuning Kirana Syamsurizal Syamsurizal Diah Tri Utami |
| author_facet | Cindra Ayuning Kirana Syamsurizal Syamsurizal Diah Tri Utami |
| author_sort | Cindra Ayuning Kirana |
| collection | DOAJ |
| description | Indonesia is one of the world's top coffee producing and exporting countries. Liberica coffee was one of the most widely cultivated types of coffee in Indonesia, especially in Tanjung Jabung Barat Jambi Province. Liberica coffee known as the coffee with highest levels of caffeine if compared with Arabica and Robusta coffee but the research about Liberica coffee was still very little if compared to the other two types of coffee. In the previous research, caffeine shown to be increasing alanine aminotransferase enzyme. Otherwise, coffee also contain chlorogenic acid which is a potent antioxidant and play a role in the protection of liver. The aim of this study are to investigate the effect of dark roasted Liberica coffee consumption on liver histological appearance, macroscopic anatomy and physiological function (serum glutamic-pyruvic transaminase (SGPT) level). This was an experimental study with posttest only control group design, using 45 male white mice and divided into 4 groups: control (with no coffee treatment), P1, P2 and P3 which were given coffee treatment consecutively 8000 ppm; 10.000 ppm and 12.000 ppm for 28 days. The result showed that liver histological damage level associated with the extent coffee intake. Although, the damage shown is still in a low level and has no impact in increasing SGPT level.
Keywords : Liberica coffee, Liver, Histological appearance, SGPT level |
| format | Article |
| id | doaj-art-c2f3334ec5944e55afac15f0ad3c7c3d |
| institution | Kabale University |
| issn | 2088-0197 2355-8989 |
| language | English |
| publishDate | 2018-10-01 |
| publisher | Indonesian Society for Cancer Chemoprevention |
| record_format | Article |
| series | ISCC (Indonesian Journal of Cancer Chemoprevention) |
| spelling | doaj-art-c2f3334ec5944e55afac15f0ad3c7c3d2025-08-20T03:49:07ZengIndonesian Society for Cancer ChemopreventionISCC (Indonesian Journal of Cancer Chemoprevention)2088-01972355-89892018-10-019315215910.14499/indonesianjcanchemoprev9iss3pp152-159172The Effect of Liberica Coffee on Liver Physiology and Histological Appearance of White MiceCindra Ayuning Kirana0Syamsurizal Syamsurizal1Diah Tri Utami2Department of Pharmacy, Science and Technology Faculty, Universitas Jambi, IndonesiaDepartment of Chemistry education, Faculty of Teacher training and Education, Universitas Jambi, IndonesiaDepartment of Pharmacy, Science and Technology Faculty, Universitas Jambi, IndonesiaIndonesia is one of the world's top coffee producing and exporting countries. Liberica coffee was one of the most widely cultivated types of coffee in Indonesia, especially in Tanjung Jabung Barat Jambi Province. Liberica coffee known as the coffee with highest levels of caffeine if compared with Arabica and Robusta coffee but the research about Liberica coffee was still very little if compared to the other two types of coffee. In the previous research, caffeine shown to be increasing alanine aminotransferase enzyme. Otherwise, coffee also contain chlorogenic acid which is a potent antioxidant and play a role in the protection of liver. The aim of this study are to investigate the effect of dark roasted Liberica coffee consumption on liver histological appearance, macroscopic anatomy and physiological function (serum glutamic-pyruvic transaminase (SGPT) level). This was an experimental study with posttest only control group design, using 45 male white mice and divided into 4 groups: control (with no coffee treatment), P1, P2 and P3 which were given coffee treatment consecutively 8000 ppm; 10.000 ppm and 12.000 ppm for 28 days. The result showed that liver histological damage level associated with the extent coffee intake. Although, the damage shown is still in a low level and has no impact in increasing SGPT level. Keywords : Liberica coffee, Liver, Histological appearance, SGPT levelhttps://ijcc.chemoprev.org/index.php/ijcc/article/view/247 |
| spellingShingle | Cindra Ayuning Kirana Syamsurizal Syamsurizal Diah Tri Utami The Effect of Liberica Coffee on Liver Physiology and Histological Appearance of White Mice ISCC (Indonesian Journal of Cancer Chemoprevention) |
| title | The Effect of Liberica Coffee on Liver Physiology and Histological Appearance of White Mice |
| title_full | The Effect of Liberica Coffee on Liver Physiology and Histological Appearance of White Mice |
| title_fullStr | The Effect of Liberica Coffee on Liver Physiology and Histological Appearance of White Mice |
| title_full_unstemmed | The Effect of Liberica Coffee on Liver Physiology and Histological Appearance of White Mice |
| title_short | The Effect of Liberica Coffee on Liver Physiology and Histological Appearance of White Mice |
| title_sort | effect of liberica coffee on liver physiology and histological appearance of white mice |
| url | https://ijcc.chemoprev.org/index.php/ijcc/article/view/247 |
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