Molecular anti-tumorigenic mechanism of Radix Polygoni Multiflori-derived exosome-like nanoparticles
The incidence and mortality rate of liver cancer are on the rise worldwide and effective therapeutic strategies are needed. Previous studies demonstrated that exosomes and exosome-like nanoparticles (ELNs) have numerous biological activities including antioxidant, anti-tumor, and anti-inflammatory e...
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Elsevier
2025-02-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025002981 |
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| author | Mingqing Yang Lining Xu Weiyu Wang |
| author_facet | Mingqing Yang Lining Xu Weiyu Wang |
| author_sort | Mingqing Yang |
| collection | DOAJ |
| description | The incidence and mortality rate of liver cancer are on the rise worldwide and effective therapeutic strategies are needed. Previous studies demonstrated that exosomes and exosome-like nanoparticles (ELNs) have numerous biological activities including antioxidant, anti-tumor, and anti-inflammatory effects. In this study, ELNs were successfully isolated for the first time from Radix Polygoni Multiflori (RPM) juice by ultracentrifugation. This indicated that RPM-ELNs could be internalized by hepatoma cells effectively and inhibit their proliferation and migration in vitro. RNA sequencing and qPCR experiments were performed, and the results of bioinformatic analyses revealed that RPM-ELNs could globally regulate expression levels of numerous genes associated with cancer and the cell cycle. In addition, it showed that RPM-ELNs mainly target liver tissue of mice in vivo. |
| format | Article |
| id | doaj-art-c2f0f9c37061410490cd3b14e5cfac1e |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-c2f0f9c37061410490cd3b14e5cfac1e2025-02-12T05:31:21ZengElsevierHeliyon2405-84402025-02-01114e41918Molecular anti-tumorigenic mechanism of Radix Polygoni Multiflori-derived exosome-like nanoparticlesMingqing Yang0Lining Xu1Weiyu Wang2State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, ChinaDepartment of General Surgery, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, ChinaZhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei, China; Corresponding author.wwyzn2020@163.comThe incidence and mortality rate of liver cancer are on the rise worldwide and effective therapeutic strategies are needed. Previous studies demonstrated that exosomes and exosome-like nanoparticles (ELNs) have numerous biological activities including antioxidant, anti-tumor, and anti-inflammatory effects. In this study, ELNs were successfully isolated for the first time from Radix Polygoni Multiflori (RPM) juice by ultracentrifugation. This indicated that RPM-ELNs could be internalized by hepatoma cells effectively and inhibit their proliferation and migration in vitro. RNA sequencing and qPCR experiments were performed, and the results of bioinformatic analyses revealed that RPM-ELNs could globally regulate expression levels of numerous genes associated with cancer and the cell cycle. In addition, it showed that RPM-ELNs mainly target liver tissue of mice in vivo.http://www.sciencedirect.com/science/article/pii/S2405844025002981Liver cancerRadix Polygoni MultifloriExosome-like nanoparticlesTreatment |
| spellingShingle | Mingqing Yang Lining Xu Weiyu Wang Molecular anti-tumorigenic mechanism of Radix Polygoni Multiflori-derived exosome-like nanoparticles Heliyon Liver cancer Radix Polygoni Multiflori Exosome-like nanoparticles Treatment |
| title | Molecular anti-tumorigenic mechanism of Radix Polygoni Multiflori-derived exosome-like nanoparticles |
| title_full | Molecular anti-tumorigenic mechanism of Radix Polygoni Multiflori-derived exosome-like nanoparticles |
| title_fullStr | Molecular anti-tumorigenic mechanism of Radix Polygoni Multiflori-derived exosome-like nanoparticles |
| title_full_unstemmed | Molecular anti-tumorigenic mechanism of Radix Polygoni Multiflori-derived exosome-like nanoparticles |
| title_short | Molecular anti-tumorigenic mechanism of Radix Polygoni Multiflori-derived exosome-like nanoparticles |
| title_sort | molecular anti tumorigenic mechanism of radix polygoni multiflori derived exosome like nanoparticles |
| topic | Liver cancer Radix Polygoni Multiflori Exosome-like nanoparticles Treatment |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025002981 |
| work_keys_str_mv | AT mingqingyang molecularantitumorigenicmechanismofradixpolygonimultifloriderivedexosomelikenanoparticles AT liningxu molecularantitumorigenicmechanismofradixpolygonimultifloriderivedexosomelikenanoparticles AT weiyuwang molecularantitumorigenicmechanismofradixpolygonimultifloriderivedexosomelikenanoparticles |