Estradiol elicits distinct firing patterns in arcuate nucleus kisspeptin neurons of females through altering ion channel conductances

Estradiol elicits distinct firing patterns in arcuate nucleus kisspeptin neurons of females through altering ion channel conductances

Hypothalamic kisspeptin (Kiss1) neurons are vital for pubertal development and reproduction. Arcuate nucleus Kiss1 (Kiss1ARH) neurons are responsible for the pulsatile release of gonadotropin-releasing hormone (GnRH). In females, the behavior of Kiss1ARH neurons, expressing Kiss1, neurokinin B (NKB)...

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Bibliographic Details
Main Authors: Jian Qiu, Margaritis Voliotis, Martha A Bosch, Xiao Feng Li, Larry S Zweifel, Krasimira Tsaneva-Atanasova, Kevin T O'Byrne, Oline K Rønnekleiv, Martin J Kelly
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-12-01
Series:eLife
Subjects:
kisspeptin neuron
17beta-estradiol
ion channels
synchronous firing
burst firing
mathematical modeling
Online Access:https://elifesciences.org/articles/96691
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