Efficacy and safety of peripherally-restricted κ-opioid receptor agonist-HSK21542 for postoperative analgesia in patients undergoing laparoscopic abdominal surgery: a randomized, placebo-controlled phase 2 trial

Efficacy and safety of peripherally-restricted κ-opioid receptor agonist-HSK21542 for postoperative analgesia in patients undergoing laparoscopic abdominal surgery: a randomized, placebo-controlled phase 2 trial

BackgroundThis phase 2 trial comprised dose exploration (stage 1) and dose confirmation stages (stage 2) to determine the safety and efficacy of HSK21542 in patients undergoing laparoscopic abdominal surgery.MethodsIn stage 1, patients were randomly allocated at a ratio of 4:1 (12 to receive HSK2154...

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Main Authors: Yinbo Zhong, Haiying Wang, Min Yan, Mengchang Yang, Jiaqiang Zhang, Ling Nan, Zhiping Wang, Jianjun Yang, Jinglei Wu, Qulian Guo, Xiaoling Hu, Hongmeng Xu, Qiang Xu, Dongxin Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Medicine
Subjects:
κ-opioid receptor agonists
postoperative analgesia
laparoscopic abdominal surgery
HSK21542
time-weighted summed pain intensity difference
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2025.1604790/full
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