Possibilities of specific immunological tests in patients with TB/HIV coinfection
The objective of the study: to study the possibilities of skin tests with tuberculosis recombinant allergen (TRA) in the diagnosis of tuberculosis in HIV-positive patients in the region with a high prevalence of tuberculosis.Subjects and Methods. Medical files of 85 patients were retrospectively anal...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
New Terra Publishing House
2021-11-01
|
| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/1580 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850223898871726080 |
|---|---|
| author | L. N. Motanova M. S. Grabovskaya I. V. Folts |
| author_facet | L. N. Motanova M. S. Grabovskaya I. V. Folts |
| author_sort | L. N. Motanova |
| collection | DOAJ |
| description | The objective of the study: to study the possibilities of skin tests with tuberculosis recombinant allergen (TRA) in the diagnosis of tuberculosis in HIV-positive patients in the region with a high prevalence of tuberculosis.Subjects and Methods. Medical files of 85 patients were retrospectively analyzed, all the patients suffered from TB/HIV coinfection and underwent the skin test with TRA.Results. The skin test with TRA was found to be significantly valuable for the diagnosis of tuberculosis in patients with TB/HIV coinfection. The correlation between the intensity of response to the TRA test and CD4+ count was detected (p = 0.011). The lowest values were observed for CD4+ counts below 100 cells/μL. The direct correlation between the intensity of response to TRA and the stage of HIV infection was proved. No effect of the form of tuberculosis, the phase of the tuberculosis disease, or drug sensitivity on the intensity of response to TRA was found. Among tuberculosis patients with bacterial excretion (n = 48), 68.8% of patients responded positively to the TRA test, and in those with no bacterial excretion, the positive reaction was observed in 81.1%. |
| format | Article |
| id | doaj-art-c2e38f361e2e4290bea4dce4c2692867 |
| institution | OA Journals |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| publishDate | 2021-11-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj-art-c2e38f361e2e4290bea4dce4c26928672025-08-20T02:05:48ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062021-11-019910465110.21292/2075-1230-2021-99-10-46-511575Possibilities of specific immunological tests in patients with TB/HIV coinfectionL. N. Motanova0M. S. Grabovskaya1I. V. Folts2Pacific State Medical UniversityNaval Clinical Hospital no. 1477Primorsky Regional TB DispensaryThe objective of the study: to study the possibilities of skin tests with tuberculosis recombinant allergen (TRA) in the diagnosis of tuberculosis in HIV-positive patients in the region with a high prevalence of tuberculosis.Subjects and Methods. Medical files of 85 patients were retrospectively analyzed, all the patients suffered from TB/HIV coinfection and underwent the skin test with TRA.Results. The skin test with TRA was found to be significantly valuable for the diagnosis of tuberculosis in patients with TB/HIV coinfection. The correlation between the intensity of response to the TRA test and CD4+ count was detected (p = 0.011). The lowest values were observed for CD4+ counts below 100 cells/μL. The direct correlation between the intensity of response to TRA and the stage of HIV infection was proved. No effect of the form of tuberculosis, the phase of the tuberculosis disease, or drug sensitivity on the intensity of response to TRA was found. Among tuberculosis patients with bacterial excretion (n = 48), 68.8% of patients responded positively to the TRA test, and in those with no bacterial excretion, the positive reaction was observed in 81.1%.https://www.tibl-journal.com/jour/article/view/1580immunological testshiv infectiontuberculosis |
| spellingShingle | L. N. Motanova M. S. Grabovskaya I. V. Folts Possibilities of specific immunological tests in patients with TB/HIV coinfection Туберкулез и болезни лёгких immunological tests hiv infection tuberculosis |
| title | Possibilities of specific immunological tests in patients with TB/HIV coinfection |
| title_full | Possibilities of specific immunological tests in patients with TB/HIV coinfection |
| title_fullStr | Possibilities of specific immunological tests in patients with TB/HIV coinfection |
| title_full_unstemmed | Possibilities of specific immunological tests in patients with TB/HIV coinfection |
| title_short | Possibilities of specific immunological tests in patients with TB/HIV coinfection |
| title_sort | possibilities of specific immunological tests in patients with tb hiv coinfection |
| topic | immunological tests hiv infection tuberculosis |
| url | https://www.tibl-journal.com/jour/article/view/1580 |
| work_keys_str_mv | AT lnmotanova possibilitiesofspecificimmunologicaltestsinpatientswithtbhivcoinfection AT msgrabovskaya possibilitiesofspecificimmunologicaltestsinpatientswithtbhivcoinfection AT ivfolts possibilitiesofspecificimmunologicaltestsinpatientswithtbhivcoinfection |