The Role of Gut Microbiota in the Prevention or Development of Atherosclerosis – A Review
Aim of the study: This study aims to consolidate current knowledge on the role of gut microbiota in atherosclerosis, examining its mechanisms of action, the impact of dietary patterns on microbial composition, and emerging therapeutic interventions. Materials and methods: A systematic review of...
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| Format: | Article |
| Language: | English |
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Nicolaus Copernicus University in Toruń
2025-04-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/59609 |
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| _version_ | 1850179193259687936 |
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| author | Marcin Początek Michał Piotrowski Piotr Serwicki Szczepan Pośpiech Jakub Prosowski |
| author_facet | Marcin Początek Michał Piotrowski Piotr Serwicki Szczepan Pośpiech Jakub Prosowski |
| author_sort | Marcin Początek |
| collection | DOAJ |
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Aim of the study:
This study aims to consolidate current knowledge on the role of gut microbiota in atherosclerosis, examining its mechanisms of action, the impact of dietary patterns on microbial composition, and emerging therapeutic interventions.
Materials and methods:
A systematic review of scientific literature was conducted through PubMed, Google Scholar, and other databases, focusing on diagnostic advancements, insights into the role of gut microbiota in atherosclerosis, and innovative therapeutic methods.
Main results:
The findings reveal that gut microbiota exerts a dual influence on atherosclerosis development through its metabolites, with SCFAs offering anti-inflammatory and cardioprotective effects, while TMAO promotes endothelial dysfunction and pro-thrombotic states. Diet emerges as a critical factor, with fiber-rich and Mediterranean-style diets enhancing SCFA production and reducing TMAO levels, whereas Western diets exacerbate dysbiosis and atherogenesis.
Conclusions:
The gut microbiota represents a dynamic and modifiable target for the prevention and management of atherosclerosis. Advancements in diagnostic tools, dietary interventions, and microbiota-based therapies provide new opportunities to address cardiovascular health challenges.
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| format | Article |
| id | doaj-art-c2e3178ac527441b84cb9178cd6426d4 |
| institution | OA Journals |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-c2e3178ac527441b84cb9178cd6426d42025-08-20T02:18:33ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-04-014010.12775/QS.2025.40.59609The Role of Gut Microbiota in the Prevention or Development of Atherosclerosis – A ReviewMarcin Początek0https://orcid.org/0009-0003-5935-3417Michał Piotrowski1https://orcid.org/0009-0009-9306-732XPiotr Serwicki2https://orcid.org/0009-0009-1381-8446Szczepan Pośpiech3https://orcid.org/0009-0001-6379-6427Jakub Prosowski4https://orcid.org/0009-0005-1288-2199OKRĘGOWY SZPITAL KOLEJOWY W KATOWICACHWojewódzki Szpital Specjalistyczny im. św. Barbary nr. 5 w SosnowcuWojewódzki Szpital Specjalistyczny im. św. Barbary nr. 5 w SosnowcuGórnośląskie Centrum Medyczne im. prof. Leszka Gieca Śląskiego Uniwersytetu Medycznego w KatowicachGórnośląskie Centrum Medyczne im. prof. Leszka Gieca Śląskiego Uniwersytetu Medycznego w Katowicach Aim of the study: This study aims to consolidate current knowledge on the role of gut microbiota in atherosclerosis, examining its mechanisms of action, the impact of dietary patterns on microbial composition, and emerging therapeutic interventions. Materials and methods: A systematic review of scientific literature was conducted through PubMed, Google Scholar, and other databases, focusing on diagnostic advancements, insights into the role of gut microbiota in atherosclerosis, and innovative therapeutic methods. Main results: The findings reveal that gut microbiota exerts a dual influence on atherosclerosis development through its metabolites, with SCFAs offering anti-inflammatory and cardioprotective effects, while TMAO promotes endothelial dysfunction and pro-thrombotic states. Diet emerges as a critical factor, with fiber-rich and Mediterranean-style diets enhancing SCFA production and reducing TMAO levels, whereas Western diets exacerbate dysbiosis and atherogenesis. Conclusions: The gut microbiota represents a dynamic and modifiable target for the prevention and management of atherosclerosis. Advancements in diagnostic tools, dietary interventions, and microbiota-based therapies provide new opportunities to address cardiovascular health challenges. https://apcz.umk.pl/QS/article/view/59609Gut microbiotaAtherosclerosisDysbiosisSCFATMAOProbiotics |
| spellingShingle | Marcin Początek Michał Piotrowski Piotr Serwicki Szczepan Pośpiech Jakub Prosowski The Role of Gut Microbiota in the Prevention or Development of Atherosclerosis – A Review Quality in Sport Gut microbiota Atherosclerosis Dysbiosis SCFA TMAO Probiotics |
| title | The Role of Gut Microbiota in the Prevention or Development of Atherosclerosis – A Review |
| title_full | The Role of Gut Microbiota in the Prevention or Development of Atherosclerosis – A Review |
| title_fullStr | The Role of Gut Microbiota in the Prevention or Development of Atherosclerosis – A Review |
| title_full_unstemmed | The Role of Gut Microbiota in the Prevention or Development of Atherosclerosis – A Review |
| title_short | The Role of Gut Microbiota in the Prevention or Development of Atherosclerosis – A Review |
| title_sort | role of gut microbiota in the prevention or development of atherosclerosis a review |
| topic | Gut microbiota Atherosclerosis Dysbiosis SCFA TMAO Probiotics |
| url | https://apcz.umk.pl/QS/article/view/59609 |
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