Prevention and management of immune-related adverse events for biliary tract cancers
Immune checkpoint inhibitors (ICIs) combined with chemotherapy has become the first-line standard treatment for advanced biliary tract cancers (BTC). However, the application of ICIs comes with its risks of immune-related adverse events (irAEs). BTC patients often face greater challenges in the diag...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Surgery Concepts & Practice
2025-03-01
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| Series: | Waike lilun yu shijian |
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| Online Access: | https://www.qk.sjtu.edu.cn/jscp/fileup/1007-9610/PDF/1751876439817-1105793041.pdf |
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| _version_ | 1849429446145081344 |
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| author | LIU Kun, GUO Wei |
| author_facet | LIU Kun, GUO Wei |
| author_sort | LIU Kun, GUO Wei |
| collection | DOAJ |
| description | Immune checkpoint inhibitors (ICIs) combined with chemotherapy has become the first-line standard treatment for advanced biliary tract cancers (BTC). However, the application of ICIs comes with its risks of immune-related adverse events (irAEs). BTC patients often face greater challenges in the diagnosis and management of irAEs, especially in the differential diagnosis of immune related hepatitis, due to the presence of special conditions such as underlying liver dysfunction and biliary obstruction. We aimed to systematically review the current status of BTC immunotherapy, the spectrum of irAEs, clinical characteristics, prevention strategies, and management principles. We focused to investigate the specificity and response measures of irAEs management in BTC patients, optimizing immunotherapy management for BTC patients, maximizing treatment benefits and ensuring patient safety, and exploring the future research directions. |
| format | Article |
| id | doaj-art-c2e21c1f3283460eb5a0f8cbf38fde84 |
| institution | Kabale University |
| issn | 1007-9610 |
| language | zho |
| publishDate | 2025-03-01 |
| publisher | Editorial Office of Journal of Surgery Concepts & Practice |
| record_format | Article |
| series | Waike lilun yu shijian |
| spelling | doaj-art-c2e21c1f3283460eb5a0f8cbf38fde842025-08-20T03:28:21ZzhoEditorial Office of Journal of Surgery Concepts & PracticeWaike lilun yu shijian1007-96102025-03-0130211211910.16139/j.1007-9610.2025.02.04Prevention and management of immune-related adverse events for biliary tract cancersLIU Kun, GUO Wei0Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaImmune checkpoint inhibitors (ICIs) combined with chemotherapy has become the first-line standard treatment for advanced biliary tract cancers (BTC). However, the application of ICIs comes with its risks of immune-related adverse events (irAEs). BTC patients often face greater challenges in the diagnosis and management of irAEs, especially in the differential diagnosis of immune related hepatitis, due to the presence of special conditions such as underlying liver dysfunction and biliary obstruction. We aimed to systematically review the current status of BTC immunotherapy, the spectrum of irAEs, clinical characteristics, prevention strategies, and management principles. We focused to investigate the specificity and response measures of irAEs management in BTC patients, optimizing immunotherapy management for BTC patients, maximizing treatment benefits and ensuring patient safety, and exploring the future research directions.https://www.qk.sjtu.edu.cn/jscp/fileup/1007-9610/PDF/1751876439817-1105793041.pdf|biliary tract cancer(btc)|immunotherapy|immune checkpoint inhibitor(ici)|immune-related adverse event(irae) |
| spellingShingle | LIU Kun, GUO Wei Prevention and management of immune-related adverse events for biliary tract cancers Waike lilun yu shijian |biliary tract cancer(btc)|immunotherapy|immune checkpoint inhibitor(ici)|immune-related adverse event(irae) |
| title | Prevention and management of immune-related adverse events for biliary tract cancers |
| title_full | Prevention and management of immune-related adverse events for biliary tract cancers |
| title_fullStr | Prevention and management of immune-related adverse events for biliary tract cancers |
| title_full_unstemmed | Prevention and management of immune-related adverse events for biliary tract cancers |
| title_short | Prevention and management of immune-related adverse events for biliary tract cancers |
| title_sort | prevention and management of immune related adverse events for biliary tract cancers |
| topic | |biliary tract cancer(btc)|immunotherapy|immune checkpoint inhibitor(ici)|immune-related adverse event(irae) |
| url | https://www.qk.sjtu.edu.cn/jscp/fileup/1007-9610/PDF/1751876439817-1105793041.pdf |
| work_keys_str_mv | AT liukunguowei preventionandmanagementofimmunerelatedadverseeventsforbiliarytractcancers |