An Estimate of the Incidence of Prostate Cancer in Africa: A Systematic Review and Meta-Analysis.
<h4>Background</h4>Prostate cancer (PCa) is rated the second most common cancer and sixth leading cause of cancer deaths among men globally. Reports show that African men suffer disproportionately from PCa compared to men from other parts of the world. It is still quite difficult to accu...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0153496&type=printable |
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| author | Davies Adeloye Rotimi Adedeji David Adewale Victor Aderemi Alexander Iseolorunkanmi Ayo Oyedokun Emeka E J Iweala Nicholas Omoregbe Charles K Ayo |
| author_facet | Davies Adeloye Rotimi Adedeji David Adewale Victor Aderemi Alexander Iseolorunkanmi Ayo Oyedokun Emeka E J Iweala Nicholas Omoregbe Charles K Ayo |
| author_sort | Davies Adeloye |
| collection | DOAJ |
| description | <h4>Background</h4>Prostate cancer (PCa) is rated the second most common cancer and sixth leading cause of cancer deaths among men globally. Reports show that African men suffer disproportionately from PCa compared to men from other parts of the world. It is still quite difficult to accurately describe the burden of PCa in Africa due to poor cancer registration systems. We systematically reviewed the literature on prostate cancer in Africa and provided a continent-wide incidence rate of PCa based on available data in the region.<h4>Methods</h4>A systematic literature search of Medline, EMBASE and Global Health from January 1980 to June 2015 was conducted, with additional search of Google Scholar, International Association of Cancer Registries (IACR), International Agency for Research on Cancer (IARC), and WHO African region websites, for studies that estimated incidence rate of PCa in any African location. Having assessed quality and consistency across selected studies, we extracted incidence rates of PCa and conducted a random effects meta-analysis.<h4>Results</h4>Our search returned 9766 records, with 40 studies spreading across 16 African countries meeting our selection criteria. We estimated a pooled PCa incidence rate of 22.0 (95% CI: 19.93-23.97) per 100,000 population, and also reported a median incidence rate of 19.5 per 100,000 population. We observed an increasing trend in PCa incidence with advancing age, and over the main years covered.<h4>Conclusion</h4>Effective cancer registration and extensive research are vital to appropriately quantifying PCa burden in Africa. We hope our findings may further assist at identifying relevant gaps, and contribute to improving knowledge, research, and interventions targeted at prostate cancer in Africa. |
| format | Article |
| id | doaj-art-c2e0504959da419c8de5ede1aae0dbdd |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-c2e0504959da419c8de5ede1aae0dbdd2025-08-20T03:27:33ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01114e015349610.1371/journal.pone.0153496An Estimate of the Incidence of Prostate Cancer in Africa: A Systematic Review and Meta-Analysis.Davies AdeloyeRotimi Adedeji DavidAdewale Victor AderemiAlexander IseolorunkanmiAyo OyedokunEmeka E J IwealaNicholas OmoregbeCharles K Ayo<h4>Background</h4>Prostate cancer (PCa) is rated the second most common cancer and sixth leading cause of cancer deaths among men globally. Reports show that African men suffer disproportionately from PCa compared to men from other parts of the world. It is still quite difficult to accurately describe the burden of PCa in Africa due to poor cancer registration systems. We systematically reviewed the literature on prostate cancer in Africa and provided a continent-wide incidence rate of PCa based on available data in the region.<h4>Methods</h4>A systematic literature search of Medline, EMBASE and Global Health from January 1980 to June 2015 was conducted, with additional search of Google Scholar, International Association of Cancer Registries (IACR), International Agency for Research on Cancer (IARC), and WHO African region websites, for studies that estimated incidence rate of PCa in any African location. Having assessed quality and consistency across selected studies, we extracted incidence rates of PCa and conducted a random effects meta-analysis.<h4>Results</h4>Our search returned 9766 records, with 40 studies spreading across 16 African countries meeting our selection criteria. We estimated a pooled PCa incidence rate of 22.0 (95% CI: 19.93-23.97) per 100,000 population, and also reported a median incidence rate of 19.5 per 100,000 population. We observed an increasing trend in PCa incidence with advancing age, and over the main years covered.<h4>Conclusion</h4>Effective cancer registration and extensive research are vital to appropriately quantifying PCa burden in Africa. We hope our findings may further assist at identifying relevant gaps, and contribute to improving knowledge, research, and interventions targeted at prostate cancer in Africa.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0153496&type=printable |
| spellingShingle | Davies Adeloye Rotimi Adedeji David Adewale Victor Aderemi Alexander Iseolorunkanmi Ayo Oyedokun Emeka E J Iweala Nicholas Omoregbe Charles K Ayo An Estimate of the Incidence of Prostate Cancer in Africa: A Systematic Review and Meta-Analysis. PLoS ONE |
| title | An Estimate of the Incidence of Prostate Cancer in Africa: A Systematic Review and Meta-Analysis. |
| title_full | An Estimate of the Incidence of Prostate Cancer in Africa: A Systematic Review and Meta-Analysis. |
| title_fullStr | An Estimate of the Incidence of Prostate Cancer in Africa: A Systematic Review and Meta-Analysis. |
| title_full_unstemmed | An Estimate of the Incidence of Prostate Cancer in Africa: A Systematic Review and Meta-Analysis. |
| title_short | An Estimate of the Incidence of Prostate Cancer in Africa: A Systematic Review and Meta-Analysis. |
| title_sort | estimate of the incidence of prostate cancer in africa a systematic review and meta analysis |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0153496&type=printable |
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