Radiation therapy results in preferential tumor antigen-specific lymphodepletion in head and neck cancer

Radiation therapy results in preferential tumor antigen-specific lymphodepletion in head and neck cancer

Abstract Human Papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) remains a challenging malignancy, with radiotherapy, alone or combined with immune checkpoint inhibitors, often failing to achieve durable disease control. Here, by conducting longitudinal multi-omic analyses...

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Bibliographic Details
Main Authors: Joseph Zenga, Musaddiq J. Awan, Anne Frei, Jamie Foeckler, Rachel Kuehn, Julia Kasprzak, Becky Massey, Jennifer Bruening, Kenneth Akakpo, Monica Shukla, Stuart J. Wong, Angela J. Mathison, Jaime Wendt Andrae, Bryan Hunt, Andrii Puzyrenko, Victor X. Jin, Abdullah A. Memon, Oscar Villarreal Espinosa, Fanghong Chen, Md Shaheduzzaman, Tyce Kearl, Peiman Hematti, Heather A. Himburg
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60827-w
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