Transdiagnostic Symptom Domains Have Distinct Patterns of Association With Head Motion During Multimodal Imaging in Children
Background: It is unclear how transdiagnostic symptoms including attention, disruptive behavior, and internalizing problems are linked to in-scanner motion in children across structural and functional magnetic resonance imaging (fMRI). In the current study, we examined whether transdiagnostic sympto...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-07-01
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| Series: | Biological Psychiatry Global Open Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667174325000606 |
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| author | Kavari Hercules Zhiyuan Liu Eleni Christofilea Jia Wei Gladys Venegas Olivia Ciocca Alice Dyer Goeun Lee Sasha Santini-Bishop Heather Shappell Dylan G. Gee Denis G. Sukhodolsky Karim Ibrahim |
| author_facet | Kavari Hercules Zhiyuan Liu Eleni Christofilea Jia Wei Gladys Venegas Olivia Ciocca Alice Dyer Goeun Lee Sasha Santini-Bishop Heather Shappell Dylan G. Gee Denis G. Sukhodolsky Karim Ibrahim |
| author_sort | Kavari Hercules |
| collection | DOAJ |
| description | Background: It is unclear how transdiagnostic symptoms including attention, disruptive behavior, and internalizing problems are linked to in-scanner motion in children across structural and functional magnetic resonance imaging (fMRI). In the current study, we examined whether transdiagnostic symptoms of attention, disruptive behavior, and internalizing problems were associated with scanner motion in children during multimodal imaging. Methods: In 9045 children ages 9 to 10 years in the ABCD (Adolescent Brain Cognitive Development) Study, logistic regression and linear mixed-effects models were used to examine associations between motion and behavior. Motion was indexed using ABCD Study quality control (QC) metrics and mean framewise displacement for T1- and T2-weighted structural, resting-state, and diffusion MRI; stop-signal task; monetary incentive delay task; and emotional n-back task. The Child Behavior Checklist was used as a continuous measure of symptom severity. Results: Greater severity of attention and disruptive behavior problems was associated with a lower likelihood of passing motion QC across imaging modalities, while increased internalizing severity was associated with a higher likelihood of passing. There was also an interaction between sex and attention-related problems in passing QC for T2-weighted and diffusion MRI scans. Increased attention and disruptive behavior problems were associated with increased mean motion, whereas increased internalizing problems were associated with decreased mean motion. Greater severity of attention problems was associated with worse performance across the fMRI tasks. Conclusions: These findings have implications for advancing the development of computational and behavioral approaches for mitigating motion effects in youths, enhancing accessibility of imaging protocols and representativeness influences across child psychiatric disorders, and identifying brain-based biomarkers. |
| format | Article |
| id | doaj-art-c2dc4b2a9f8348499ae0c88d57db8fe2 |
| institution | OA Journals |
| issn | 2667-1743 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biological Psychiatry Global Open Science |
| spelling | doaj-art-c2dc4b2a9f8348499ae0c88d57db8fe22025-08-20T02:17:13ZengElsevierBiological Psychiatry Global Open Science2667-17432025-07-015410050610.1016/j.bpsgos.2025.100506Transdiagnostic Symptom Domains Have Distinct Patterns of Association With Head Motion During Multimodal Imaging in ChildrenKavari Hercules0Zhiyuan Liu1Eleni Christofilea2Jia Wei3Gladys Venegas4Olivia Ciocca5Alice Dyer6Goeun Lee7Sasha Santini-Bishop8Heather Shappell9Dylan G. Gee10Denis G. Sukhodolsky11Karim Ibrahim12Child Study Center, Yale University School of Medicine, New Haven, Connecticut; Department of Social and Behavioral Sciences, Yale University School of Public Health, New Haven, ConnecticutChild Study Center, Yale University School of Medicine, New Haven, Connecticut; Department of Social and Behavioral Sciences, Yale University School of Public Health, New Haven, ConnecticutChild Study Center, Yale University School of Medicine, New Haven, ConnecticutChild Study Center, Yale University School of Medicine, New Haven, ConnecticutChild Study Center, Yale University School of Medicine, New Haven, ConnecticutChild Study Center, Yale University School of Medicine, New Haven, ConnecticutChild Study Center, Yale University School of Medicine, New Haven, ConnecticutChild Study Center, Yale University School of Medicine, New Haven, ConnecticutChild Study Center, Yale University School of Medicine, New Haven, ConnecticutDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North CarolinaChild Study Center, Yale University School of Medicine, New Haven, Connecticut; Department of Psychology, Yale University, New Haven, Connecticut; Wu Tsai Institute, Yale University, New Haven, ConnecticutChild Study Center, Yale University School of Medicine, New Haven, ConnecticutChild Study Center, Yale University School of Medicine, New Haven, Connecticut; Department of Psychology, Yale University, New Haven, Connecticut; Wu Tsai Institute, Yale University, New Haven, Connecticut; Address correspondence to Karim Ibrahim, Psy.D.Background: It is unclear how transdiagnostic symptoms including attention, disruptive behavior, and internalizing problems are linked to in-scanner motion in children across structural and functional magnetic resonance imaging (fMRI). In the current study, we examined whether transdiagnostic symptoms of attention, disruptive behavior, and internalizing problems were associated with scanner motion in children during multimodal imaging. Methods: In 9045 children ages 9 to 10 years in the ABCD (Adolescent Brain Cognitive Development) Study, logistic regression and linear mixed-effects models were used to examine associations between motion and behavior. Motion was indexed using ABCD Study quality control (QC) metrics and mean framewise displacement for T1- and T2-weighted structural, resting-state, and diffusion MRI; stop-signal task; monetary incentive delay task; and emotional n-back task. The Child Behavior Checklist was used as a continuous measure of symptom severity. Results: Greater severity of attention and disruptive behavior problems was associated with a lower likelihood of passing motion QC across imaging modalities, while increased internalizing severity was associated with a higher likelihood of passing. There was also an interaction between sex and attention-related problems in passing QC for T2-weighted and diffusion MRI scans. Increased attention and disruptive behavior problems were associated with increased mean motion, whereas increased internalizing problems were associated with decreased mean motion. Greater severity of attention problems was associated with worse performance across the fMRI tasks. Conclusions: These findings have implications for advancing the development of computational and behavioral approaches for mitigating motion effects in youths, enhancing accessibility of imaging protocols and representativeness influences across child psychiatric disorders, and identifying brain-based biomarkers.http://www.sciencedirect.com/science/article/pii/S2667174325000606DevelopmentDiffusion MRIMotionMRIMultimodal imagingResting-state |
| spellingShingle | Kavari Hercules Zhiyuan Liu Eleni Christofilea Jia Wei Gladys Venegas Olivia Ciocca Alice Dyer Goeun Lee Sasha Santini-Bishop Heather Shappell Dylan G. Gee Denis G. Sukhodolsky Karim Ibrahim Transdiagnostic Symptom Domains Have Distinct Patterns of Association With Head Motion During Multimodal Imaging in Children Biological Psychiatry Global Open Science Development Diffusion MRI Motion MRI Multimodal imaging Resting-state |
| title | Transdiagnostic Symptom Domains Have Distinct Patterns of Association With Head Motion During Multimodal Imaging in Children |
| title_full | Transdiagnostic Symptom Domains Have Distinct Patterns of Association With Head Motion During Multimodal Imaging in Children |
| title_fullStr | Transdiagnostic Symptom Domains Have Distinct Patterns of Association With Head Motion During Multimodal Imaging in Children |
| title_full_unstemmed | Transdiagnostic Symptom Domains Have Distinct Patterns of Association With Head Motion During Multimodal Imaging in Children |
| title_short | Transdiagnostic Symptom Domains Have Distinct Patterns of Association With Head Motion During Multimodal Imaging in Children |
| title_sort | transdiagnostic symptom domains have distinct patterns of association with head motion during multimodal imaging in children |
| topic | Development Diffusion MRI Motion MRI Multimodal imaging Resting-state |
| url | http://www.sciencedirect.com/science/article/pii/S2667174325000606 |
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