Clerodendranthus spicatus [Orthosiphon aristatus (Blume) Miq.] maintains uric acid homeostasis via regulating gut microbiota and restrains renal inflammation in hyperuricemic nephropathy

Clerodendranthus spicatus [Orthosiphon aristatus (Blume) Miq.] maintains uric acid homeostasis via regulating gut microbiota and restrains renal inflammation in hyperuricemic nephropathy

IntroductionThe kidney damage caused by the deposition of uric acid in the kidneys is of urgent need for new treatment drugs due to its complex pathogenesis. Orthosiphon aristatus (Blume) Miq. Also known as C. spicatus, which has a significant therapeutic effect on hyperuricemia nephropathy (HN), ho...

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Main Authors: Yang Wang, Kaiwen Li, Siya Yan, Ge Li, Meifang Cheng, Qian Chen, Yuzheng Wu, Dan Wang, Tao Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Pharmacology
Subjects:
Orthosiphon aristatus (Blume) Miq.
hyperuricemic nephropathy
gut microbiota
renal fibrosis
NLRP3 signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1485861/full
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