Proteomic profile data of rabbit stem cell secretome and stem cell/tenocyte secretome and gene expression data, scratch assay data and CAM assay data of tenocyte in vitro cultures treated with these two different secretomesMendeley Data
Tendon rupture repairs exhibit two main problems. On the one hand side, they often lead to scar formation during healing, which has inferior mechanical properties and may lead to re-ruptures. On the other hand side, fibrotic adhesion formation to the surrounding tissue may occur, which hampers prope...
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Elsevier
2025-08-01
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| Series: | Data in Brief |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340925005165 |
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| author | Petra Wolint Iris Miescher Asma Mechakra Patrick Jäger Julia Rieber Maurizio Calcagni Pietro Giovanoli Viola Vogel Jess G. Snedeker Johanna Buschmann |
| author_facet | Petra Wolint Iris Miescher Asma Mechakra Patrick Jäger Julia Rieber Maurizio Calcagni Pietro Giovanoli Viola Vogel Jess G. Snedeker Johanna Buschmann |
| author_sort | Petra Wolint |
| collection | DOAJ |
| description | Tendon rupture repairs exhibit two main problems. On the one hand side, they often lead to scar formation during healing, which has inferior mechanical properties and may lead to re-ruptures. On the other hand side, fibrotic adhesion formation to the surrounding tissue may occur, which hampers proper range of motion.Cell-free approaches to support tendon healing are getting increasing attention worldwide. We have therefore obtained two different cell secretomes from New Zealand White rabbit adipose tissue-derived mesenchymal stem cells (ADSCs) or from a 3:1 mixed culture of ADSCs and rabbit Achilles tenocytes. These cell secretomes were examined and compared in terms of their proteomic profiles and biological activities. Applied to a tenocyte in vitro culture, gene expression analysis data and scratch assay data are provided. To determine the angiogenic potential, the chorioallantoic membrane of the chicken embryo (CAM) was treated with the secretomes. |
| format | Article |
| id | doaj-art-c2d91b37896b4bb696d046b38faf9252 |
| institution | DOAJ |
| issn | 2352-3409 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj-art-c2d91b37896b4bb696d046b38faf92522025-08-20T02:59:41ZengElsevierData in Brief2352-34092025-08-016111178910.1016/j.dib.2025.111789Proteomic profile data of rabbit stem cell secretome and stem cell/tenocyte secretome and gene expression data, scratch assay data and CAM assay data of tenocyte in vitro cultures treated with these two different secretomesMendeley DataPetra Wolint0Iris Miescher1Asma Mechakra2Patrick Jäger3Julia Rieber4Maurizio Calcagni5Pietro Giovanoli6Viola Vogel7Jess G. Snedeker8Johanna Buschmann9Division of Surgical Research, University Hospital of Zurich, 8091 Zurich, Switzerland; Department of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8091 Zurich, SwitzerlandDepartment of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8091 Zurich, SwitzerlandInstitute for Biomechanics, ETH Zurich, 8092 Zurich, Switzerland; Balgrist University Hospital, University of Zurich, 8008 Zurich, SwitzerlandInstitute for Biomechanics, ETH Zurich, 8092 Zurich, Switzerland; Balgrist University Hospital, University of Zurich, 8008 Zurich, SwitzerlandDepartment of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8091 Zurich, SwitzerlandDepartment of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8091 Zurich, SwitzerlandDepartment of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8091 Zurich, SwitzerlandLaboratory of Applied Mechanobiology, Department of Health Sciences and Technology, ETH Zurich, 8092 Zurich, SwitzerlandInstitute for Biomechanics, ETH Zurich, 8092 Zurich, Switzerland; Balgrist University Hospital, University of Zurich, 8008 Zurich, SwitzerlandDivision of Surgical Research, University Hospital of Zurich, 8091 Zurich, Switzerland; Department of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8091 Zurich, Switzerland; Corresponding author at: Division of Surgical Research, University Hospital of Zurich, 8091 Zurich, Switzerland.Tendon rupture repairs exhibit two main problems. On the one hand side, they often lead to scar formation during healing, which has inferior mechanical properties and may lead to re-ruptures. On the other hand side, fibrotic adhesion formation to the surrounding tissue may occur, which hampers proper range of motion.Cell-free approaches to support tendon healing are getting increasing attention worldwide. We have therefore obtained two different cell secretomes from New Zealand White rabbit adipose tissue-derived mesenchymal stem cells (ADSCs) or from a 3:1 mixed culture of ADSCs and rabbit Achilles tenocytes. These cell secretomes were examined and compared in terms of their proteomic profiles and biological activities. Applied to a tenocyte in vitro culture, gene expression analysis data and scratch assay data are provided. To determine the angiogenic potential, the chorioallantoic membrane of the chicken embryo (CAM) was treated with the secretomes.http://www.sciencedirect.com/science/article/pii/S2352340925005165AngiogenesisProteomicsSecretomeMesenchymal stem cellsTenocytesTendon healing |
| spellingShingle | Petra Wolint Iris Miescher Asma Mechakra Patrick Jäger Julia Rieber Maurizio Calcagni Pietro Giovanoli Viola Vogel Jess G. Snedeker Johanna Buschmann Proteomic profile data of rabbit stem cell secretome and stem cell/tenocyte secretome and gene expression data, scratch assay data and CAM assay data of tenocyte in vitro cultures treated with these two different secretomesMendeley Data Data in Brief Angiogenesis Proteomics Secretome Mesenchymal stem cells Tenocytes Tendon healing |
| title | Proteomic profile data of rabbit stem cell secretome and stem cell/tenocyte secretome and gene expression data, scratch assay data and CAM assay data of tenocyte in vitro cultures treated with these two different secretomesMendeley Data |
| title_full | Proteomic profile data of rabbit stem cell secretome and stem cell/tenocyte secretome and gene expression data, scratch assay data and CAM assay data of tenocyte in vitro cultures treated with these two different secretomesMendeley Data |
| title_fullStr | Proteomic profile data of rabbit stem cell secretome and stem cell/tenocyte secretome and gene expression data, scratch assay data and CAM assay data of tenocyte in vitro cultures treated with these two different secretomesMendeley Data |
| title_full_unstemmed | Proteomic profile data of rabbit stem cell secretome and stem cell/tenocyte secretome and gene expression data, scratch assay data and CAM assay data of tenocyte in vitro cultures treated with these two different secretomesMendeley Data |
| title_short | Proteomic profile data of rabbit stem cell secretome and stem cell/tenocyte secretome and gene expression data, scratch assay data and CAM assay data of tenocyte in vitro cultures treated with these two different secretomesMendeley Data |
| title_sort | proteomic profile data of rabbit stem cell secretome and stem cell tenocyte secretome and gene expression data scratch assay data and cam assay data of tenocyte in vitro cultures treated with these two different secretomesmendeley data |
| topic | Angiogenesis Proteomics Secretome Mesenchymal stem cells Tenocytes Tendon healing |
| url | http://www.sciencedirect.com/science/article/pii/S2352340925005165 |
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