Signaling by intracellular β2-adrenergic receptors regulates AMPA receptor trafficking and synaptic plasticity

Signaling by intracellular β2-adrenergic receptors regulates AMPA receptor trafficking and synaptic plasticity

Summary: Signaling by norepinephrine (NE) via adrenergic receptors (ARs) mediates attention, yet the underlying molecular mechanisms are largely unknown. AMPA receptors (AMPARs) form a complex with β2ARs, Gs, adenylyl cyclase, and protein kinase A (PKA) to augment AMPAR phosphorylation and, thereby,...

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Main Authors: Boram Lee, Xiaomin Xing, Erik A. Hammes, Zhuoer Zeng, Zoila M. Estrada-Tobar, Karam Kim, Kyle E. Ireton, Kwun Nok Mimi Man, Ariel A. Jacobi, Ruben A. Berumen, Justin C. Weiner, Ao Shen, Bing Xu, Joanne Wang, Paul J. Gasser, Manuel F. Navedo, Yang K. Xiang, Elva Díaz, Chao-Yin Chen, Mary C. Horne, Johannes W. Hell
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Cell Reports
Subjects:
CP: Neuroscience
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472500782X
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