Flavouring Group Evaluation 217 Revision 3 (FGE.217Rev3): consideration of genotoxic potential for α,β‐unsaturated ketones and precursors from chemical subgroup 4.1 of FGE.19: lactones
Abstract The Panel on Food Additives and Flavourings of the European Food Safety Authority was requested to evaluate the genotoxic potential of four flavouring substances [FL‐no: 10.023, 10.030, 10.057 and 13.012] from subgroup 4.1 of FGE.19. For three of these substances [FL‐no: 10.023, 10.030 and...
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2023-04-01
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| Online Access: | https://doi.org/10.2903/j.efsa.2023.7967 |
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| author | EFSA Panel on Food Additives and Flavourings (FAF) Maged Younes Gabriele Aquilina Laurence Castle Gisela Degen Karl‐Heinz Engel Paul J Fowler Maria José Frutos Fernandez Peter Fürst Ursula Gundert‐Remy Rainer Gürtler Trine Husøy Melania Manco Peter Moldeus Sabina Passamonti Romina Shah Ine Waalkens‐Berendsen Matthew Wright Romualdo Benigni Claudia Bolognesi Kevin Chipman Eugenia Cordelli Maria Carfì Wim Mennes |
| author_facet | EFSA Panel on Food Additives and Flavourings (FAF) Maged Younes Gabriele Aquilina Laurence Castle Gisela Degen Karl‐Heinz Engel Paul J Fowler Maria José Frutos Fernandez Peter Fürst Ursula Gundert‐Remy Rainer Gürtler Trine Husøy Melania Manco Peter Moldeus Sabina Passamonti Romina Shah Ine Waalkens‐Berendsen Matthew Wright Romualdo Benigni Claudia Bolognesi Kevin Chipman Eugenia Cordelli Maria Carfì Wim Mennes |
| author_sort | EFSA Panel on Food Additives and Flavourings (FAF) |
| collection | DOAJ |
| description | Abstract The Panel on Food Additives and Flavourings of the European Food Safety Authority was requested to evaluate the genotoxic potential of four flavouring substances [FL‐no: 10.023, 10.030, 10.057 and 13.012] from subgroup 4.1 of FGE.19. For three of these substances [FL‐no: 10.023, 10.030 and 13.012], the concern for genotoxicity has been ruled out in previous revisions of Flavouring Group Evaluation 217 (FGE.217). However, in FGE.217Rev2, a concern for genotoxicity could not be ruled out for 3a,4,5,7a‐tetrahydro‐3,6‐dimethylbenzofuran‐2(3H)‐one [FL‐no: 10.057]. After publication of FGE.217Rev2, industry provided additional genotoxicity studies for [FL‐no: 10.057], which are evaluated in the present opinion FGE.217Rev3. The flavouring substance [FL‐no: 10.057] did not induce gene mutations or numerical or structural chromosomal aberrations in vitro. Based on these data, the Panel concluded that the concern for genotoxicity is ruled out for [FL‐no: 10.057]. Consequently, it can be evaluated through the Procedure. |
| format | Article |
| id | doaj-art-c2cfff8cfabd47ed9b8fbc8b7e05aaa1 |
| institution | DOAJ |
| issn | 1831-4732 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Wiley |
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| series | EFSA Journal |
| spelling | doaj-art-c2cfff8cfabd47ed9b8fbc8b7e05aaa12025-08-20T03:18:46ZengWileyEFSA Journal1831-47322023-04-01214n/an/a10.2903/j.efsa.2023.7967Flavouring Group Evaluation 217 Revision 3 (FGE.217Rev3): consideration of genotoxic potential for α,β‐unsaturated ketones and precursors from chemical subgroup 4.1 of FGE.19: lactonesEFSA Panel on Food Additives and Flavourings (FAF)Maged YounesGabriele AquilinaLaurence CastleGisela DegenKarl‐Heinz EngelPaul J FowlerMaria José Frutos FernandezPeter FürstUrsula Gundert‐RemyRainer GürtlerTrine HusøyMelania MancoPeter MoldeusSabina PassamontiRomina ShahIne Waalkens‐BerendsenMatthew WrightRomualdo BenigniClaudia BolognesiKevin ChipmanEugenia CordelliMaria CarfìWim MennesAbstract The Panel on Food Additives and Flavourings of the European Food Safety Authority was requested to evaluate the genotoxic potential of four flavouring substances [FL‐no: 10.023, 10.030, 10.057 and 13.012] from subgroup 4.1 of FGE.19. For three of these substances [FL‐no: 10.023, 10.030 and 13.012], the concern for genotoxicity has been ruled out in previous revisions of Flavouring Group Evaluation 217 (FGE.217). However, in FGE.217Rev2, a concern for genotoxicity could not be ruled out for 3a,4,5,7a‐tetrahydro‐3,6‐dimethylbenzofuran‐2(3H)‐one [FL‐no: 10.057]. After publication of FGE.217Rev2, industry provided additional genotoxicity studies for [FL‐no: 10.057], which are evaluated in the present opinion FGE.217Rev3. The flavouring substance [FL‐no: 10.057] did not induce gene mutations or numerical or structural chromosomal aberrations in vitro. Based on these data, the Panel concluded that the concern for genotoxicity is ruled out for [FL‐no: 10.057]. Consequently, it can be evaluated through the Procedure.https://doi.org/10.2903/j.efsa.2023.7967FGE.217α,β‐unsaturated ketoneslactonesflavouring substancessubgroup 4.1FGE.19 |
| spellingShingle | EFSA Panel on Food Additives and Flavourings (FAF) Maged Younes Gabriele Aquilina Laurence Castle Gisela Degen Karl‐Heinz Engel Paul J Fowler Maria José Frutos Fernandez Peter Fürst Ursula Gundert‐Remy Rainer Gürtler Trine Husøy Melania Manco Peter Moldeus Sabina Passamonti Romina Shah Ine Waalkens‐Berendsen Matthew Wright Romualdo Benigni Claudia Bolognesi Kevin Chipman Eugenia Cordelli Maria Carfì Wim Mennes Flavouring Group Evaluation 217 Revision 3 (FGE.217Rev3): consideration of genotoxic potential for α,β‐unsaturated ketones and precursors from chemical subgroup 4.1 of FGE.19: lactones EFSA Journal FGE.217 α,β‐unsaturated ketones lactones flavouring substances subgroup 4.1 FGE.19 |
| title | Flavouring Group Evaluation 217 Revision 3 (FGE.217Rev3): consideration of genotoxic potential for α,β‐unsaturated ketones and precursors from chemical subgroup 4.1 of FGE.19: lactones |
| title_full | Flavouring Group Evaluation 217 Revision 3 (FGE.217Rev3): consideration of genotoxic potential for α,β‐unsaturated ketones and precursors from chemical subgroup 4.1 of FGE.19: lactones |
| title_fullStr | Flavouring Group Evaluation 217 Revision 3 (FGE.217Rev3): consideration of genotoxic potential for α,β‐unsaturated ketones and precursors from chemical subgroup 4.1 of FGE.19: lactones |
| title_full_unstemmed | Flavouring Group Evaluation 217 Revision 3 (FGE.217Rev3): consideration of genotoxic potential for α,β‐unsaturated ketones and precursors from chemical subgroup 4.1 of FGE.19: lactones |
| title_short | Flavouring Group Evaluation 217 Revision 3 (FGE.217Rev3): consideration of genotoxic potential for α,β‐unsaturated ketones and precursors from chemical subgroup 4.1 of FGE.19: lactones |
| title_sort | flavouring group evaluation 217 revision 3 fge 217rev3 consideration of genotoxic potential for α β unsaturated ketones and precursors from chemical subgroup 4 1 of fge 19 lactones |
| topic | FGE.217 α,β‐unsaturated ketones lactones flavouring substances subgroup 4.1 FGE.19 |
| url | https://doi.org/10.2903/j.efsa.2023.7967 |
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