Effect of supervised exercise training on objectively measured physical activity in patients during anthracycline therapyKey points
Introduction: It is unknown what the benefits of cardio-oncologic rehabilitation programmes on cardiorespiratory fitness and cancer fatigue during anthracycline-based chemotherapies (AC) are with supervised exercise training (ET), compared to PA advice and tracking only. Methods: Patients with breas...
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Elsevier
2024-12-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772696724000243 |
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| author | Caroline Schneider Laura Stuetz Annika Dierks Kristin L. Campbell Matthias Wilhelm Prisca Eser |
| author_facet | Caroline Schneider Laura Stuetz Annika Dierks Kristin L. Campbell Matthias Wilhelm Prisca Eser |
| author_sort | Caroline Schneider |
| collection | DOAJ |
| description | Introduction: It is unknown what the benefits of cardio-oncologic rehabilitation programmes on cardiorespiratory fitness and cancer fatigue during anthracycline-based chemotherapies (AC) are with supervised exercise training (ET), compared to PA advice and tracking only. Methods: Patients with breast cancer or lymphoma were recruited from four cancer centres and randomly assigned to three months supervised ET during (EXduringAC) or after (EXpostAC) AC. All patients were counselled on physical activity (PA) and PA was objectively measured with an activity tracker. Primary endpoints were peak VO2, fatigue and quality of life (QoL) after AC (AC-end) and at follow-up (3 months after completion of AC). Secondary endpoints were daily PA and daily steps during AC and follow-up phase, which were compared between days with and without centre-based training sessions. All analyses were performed by linear mixed models. Results: Fifty-seven patients (median [1st and 3rd quartiles] age 47 years [38, 57 years]; 95 % women) consented to participate, of whom data from 51 patients were available. Despite the fact that PA on days with centre-based training sessions was 28 (95 % confidence interval 24–32) min higher with 4382 (3995–4768) more steps, neither PA nor steps differed between groups in neither AC nor follow-up phase, nor were there between group differences in peak VO2, QoL or fatigue at any time point. Conclusion: In physically active patients with cancer, PA advice and using an activity tracker was equally effective on changes in peak VO2, fatigue, or QoL as enrolling in centre-based ET performed during or after AC. Trial registration: NCT03850171, February 21, 2019. |
| format | Article |
| id | doaj-art-c2c9ccd1b4f84ae5a4f8a36384dbc4b2 |
| institution | OA Journals |
| issn | 2772-6967 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JSAMS Plus |
| spelling | doaj-art-c2c9ccd1b4f84ae5a4f8a36384dbc4b22025-08-20T01:52:45ZengElsevierJSAMS Plus2772-69672024-12-01410007510.1016/j.jsampl.2024.100075Effect of supervised exercise training on objectively measured physical activity in patients during anthracycline therapyKey pointsCaroline Schneider0Laura Stuetz1Annika Dierks2Kristin L. Campbell3Matthias Wilhelm4Prisca Eser5Rehabilitation & Sports Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland; Berner Fachhochschule für Gesundheit, Fachbereich Pflege, Bern, Switzerland; Graduate School for Health Sciences, University of Bern, Bern, SwitzerlandRehabilitation & Sports Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland; Department of Health Sciences and Technology, Swiss Federal Institute of Technology, Zurich, SwitzerlandRehabilitation & Sports Medicine, Inselspital, Bern University Hospital, University of Bern, SwitzerlandFaculty of Medicine, University of British Columbia, Vancouver, BC, CanadaRehabilitation & Sports Medicine, Inselspital, Bern University Hospital, University of Bern, SwitzerlandRehabilitation & Sports Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland; Corresponding author. Medical Division Rehabilitation & Sports Medicine, Inselspital, Bern University Hospital, University of Bern, CH-3010 Bern, Switzerland.Introduction: It is unknown what the benefits of cardio-oncologic rehabilitation programmes on cardiorespiratory fitness and cancer fatigue during anthracycline-based chemotherapies (AC) are with supervised exercise training (ET), compared to PA advice and tracking only. Methods: Patients with breast cancer or lymphoma were recruited from four cancer centres and randomly assigned to three months supervised ET during (EXduringAC) or after (EXpostAC) AC. All patients were counselled on physical activity (PA) and PA was objectively measured with an activity tracker. Primary endpoints were peak VO2, fatigue and quality of life (QoL) after AC (AC-end) and at follow-up (3 months after completion of AC). Secondary endpoints were daily PA and daily steps during AC and follow-up phase, which were compared between days with and without centre-based training sessions. All analyses were performed by linear mixed models. Results: Fifty-seven patients (median [1st and 3rd quartiles] age 47 years [38, 57 years]; 95 % women) consented to participate, of whom data from 51 patients were available. Despite the fact that PA on days with centre-based training sessions was 28 (95 % confidence interval 24–32) min higher with 4382 (3995–4768) more steps, neither PA nor steps differed between groups in neither AC nor follow-up phase, nor were there between group differences in peak VO2, QoL or fatigue at any time point. Conclusion: In physically active patients with cancer, PA advice and using an activity tracker was equally effective on changes in peak VO2, fatigue, or QoL as enrolling in centre-based ET performed during or after AC. Trial registration: NCT03850171, February 21, 2019.http://www.sciencedirect.com/science/article/pii/S2772696724000243Physical activityExercise therapyStep countActivity trackingBreast cancerLymphoma |
| spellingShingle | Caroline Schneider Laura Stuetz Annika Dierks Kristin L. Campbell Matthias Wilhelm Prisca Eser Effect of supervised exercise training on objectively measured physical activity in patients during anthracycline therapyKey points JSAMS Plus Physical activity Exercise therapy Step count Activity tracking Breast cancer Lymphoma |
| title | Effect of supervised exercise training on objectively measured physical activity in patients during anthracycline therapyKey points |
| title_full | Effect of supervised exercise training on objectively measured physical activity in patients during anthracycline therapyKey points |
| title_fullStr | Effect of supervised exercise training on objectively measured physical activity in patients during anthracycline therapyKey points |
| title_full_unstemmed | Effect of supervised exercise training on objectively measured physical activity in patients during anthracycline therapyKey points |
| title_short | Effect of supervised exercise training on objectively measured physical activity in patients during anthracycline therapyKey points |
| title_sort | effect of supervised exercise training on objectively measured physical activity in patients during anthracycline therapykey points |
| topic | Physical activity Exercise therapy Step count Activity tracking Breast cancer Lymphoma |
| url | http://www.sciencedirect.com/science/article/pii/S2772696724000243 |
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