Associations of physical activity with the risks of osteoarthritis and subtypes: a population-based cohort study of UK Biobank data
Aims: This study aimed to investigate the relationship between physical activity (PA) and the risk of osteoarthritis (OA) and its subtypes. Methods: We included participants from the UK Biobank aged 37 to 73 years from February 2006 to June 2010. Baseline PA levels were categorized as high (≥ 3,000...
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The British Editorial Society of Bone & Joint Surgery
2025-07-01
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| Series: | Bone & Joint Research |
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| Online Access: | https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.147.BJR-2024-0529.R1 |
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| author | Huijie Gu Rong Chen Tingting Fang Jun Xu Yiming Zhang Chong Bian Xiangyang Cheng Xiaofan Yin Chuhuai Wang Guangnan Chen |
| author_facet | Huijie Gu Rong Chen Tingting Fang Jun Xu Yiming Zhang Chong Bian Xiangyang Cheng Xiaofan Yin Chuhuai Wang Guangnan Chen |
| author_sort | Huijie Gu |
| collection | DOAJ |
| description | Aims: This study aimed to investigate the relationship between physical activity (PA) and the risk of osteoarthritis (OA) and its subtypes. Methods: We included participants from the UK Biobank aged 37 to 73 years from February 2006 to June 2010. Baseline PA levels were categorized as high (≥ 3,000 metabolic equivalent of task (MET)-min/week), moderate (600 to < 3,000 MET-min/week), or low PA (< 600 MET-min/week) based on current public health guidelines. The associations between PA and OA and its main subtypes (hand, hip, and knee OA) were analyzed using Cox-proportional hazard models. The mediating role of BMI was tested under a causal counterfactual framework. Results: The median follow-up period was 12.50 years, with 25,036 incident total OA cases. Compared to low PA, we found no significant association between moderate PA and total OA risk. However, high PA significantly increased the risk of total OA by 19% (hazard ratio (HR) 1.19, 95% CI 1.15 to 1.23). This result is consistent with knee OA and hip OA, where HR was 1.25 (95% CI 1.19 to 1.31) for knee OA risk and 1.17 (95% CI 1.10 to 1.24) for hip OA risk, respectively. Moderate PA was associated with 14% (HR 0.86, 95% CI 0.76 to 0.97) reduction in the risk of hand OA. Moreover, we found that BMI mediated the association between PA and OA risk, with the mediating proportion for total OA, hand OA, knee OA, and hip OA, at 75.48%, 2.42%, 10.20%, and 51.39%, respectively. Conclusion: These findings suggest that high levels of PA increased the risk of total OA, as well as knee and hip OA, while moderate levels of PA significantly mitigate the risk of hand OA. BMI appears to mediate the relationship between PA and OA risk. Future research should elucidate the underlying mechanisms. Cite this article: Bone Joint Res 2025;14(7):656–665. |
| format | Article |
| id | doaj-art-c2c8811b6f7a4ebd9f9e5fc73df7b204 |
| institution | Kabale University |
| issn | 2046-3758 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | The British Editorial Society of Bone & Joint Surgery |
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| series | Bone & Joint Research |
| spelling | doaj-art-c2c8811b6f7a4ebd9f9e5fc73df7b2042025-08-20T03:58:49ZengThe British Editorial Society of Bone & Joint SurgeryBone & Joint Research2046-37582025-07-0114765666510.1302/2046-3758.147.BJR-2024-0529.R1Associations of physical activity with the risks of osteoarthritis and subtypes: a population-based cohort study of UK Biobank dataHuijie Gu0Rong Chen1Tingting Fang2Jun Xu3Yiming Zhang4Chong Bian5Xiangyang Cheng6Xiaofan Yin7Chuhuai Wang8Guangnan Chen9Department of Orthopedics, Minhang Hospital, Fudan University, Shanghai, ChinaDepartment of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, ChinaDepartment of Infectious Diseases, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Orthopedics, Minhang Hospital, Fudan University, Shanghai, ChinaDepartment of Orthopedics, Minhang Hospital, Fudan University, Shanghai, ChinaDepartment of Orthopedics, Minhang Hospital, Fudan University, Shanghai, ChinaDepartment of Orthopedics, Minhang Hospital, Fudan University, Shanghai, ChinaDepartment of Orthopedics, Minhang Hospital, Fudan University, Shanghai, ChinaDepartment of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, ChinaDepartment of Orthopedics, Minhang Hospital, Fudan University, Shanghai, ChinaAims: This study aimed to investigate the relationship between physical activity (PA) and the risk of osteoarthritis (OA) and its subtypes. Methods: We included participants from the UK Biobank aged 37 to 73 years from February 2006 to June 2010. Baseline PA levels were categorized as high (≥ 3,000 metabolic equivalent of task (MET)-min/week), moderate (600 to < 3,000 MET-min/week), or low PA (< 600 MET-min/week) based on current public health guidelines. The associations between PA and OA and its main subtypes (hand, hip, and knee OA) were analyzed using Cox-proportional hazard models. The mediating role of BMI was tested under a causal counterfactual framework. Results: The median follow-up period was 12.50 years, with 25,036 incident total OA cases. Compared to low PA, we found no significant association between moderate PA and total OA risk. However, high PA significantly increased the risk of total OA by 19% (hazard ratio (HR) 1.19, 95% CI 1.15 to 1.23). This result is consistent with knee OA and hip OA, where HR was 1.25 (95% CI 1.19 to 1.31) for knee OA risk and 1.17 (95% CI 1.10 to 1.24) for hip OA risk, respectively. Moderate PA was associated with 14% (HR 0.86, 95% CI 0.76 to 0.97) reduction in the risk of hand OA. Moreover, we found that BMI mediated the association between PA and OA risk, with the mediating proportion for total OA, hand OA, knee OA, and hip OA, at 75.48%, 2.42%, 10.20%, and 51.39%, respectively. Conclusion: These findings suggest that high levels of PA increased the risk of total OA, as well as knee and hip OA, while moderate levels of PA significantly mitigate the risk of hand OA. BMI appears to mediate the relationship between PA and OA risk. Future research should elucidate the underlying mechanisms. Cite this article: Bone Joint Res 2025;14(7):656–665.https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.147.BJR-2024-0529.R1physical activityosteoarthritisuk biobankosteoarthritis (oa)hipsbmiknee osteoarthritiskneescox proportional hazards modelsdiabetes mellitusobesityhypertensiondepression |
| spellingShingle | Huijie Gu Rong Chen Tingting Fang Jun Xu Yiming Zhang Chong Bian Xiangyang Cheng Xiaofan Yin Chuhuai Wang Guangnan Chen Associations of physical activity with the risks of osteoarthritis and subtypes: a population-based cohort study of UK Biobank data Bone & Joint Research physical activity osteoarthritis uk biobank osteoarthritis (oa) hips bmi knee osteoarthritis knees cox proportional hazards models diabetes mellitus obesity hypertension depression |
| title | Associations of physical activity with the risks of osteoarthritis and subtypes: a population-based cohort study of UK Biobank data |
| title_full | Associations of physical activity with the risks of osteoarthritis and subtypes: a population-based cohort study of UK Biobank data |
| title_fullStr | Associations of physical activity with the risks of osteoarthritis and subtypes: a population-based cohort study of UK Biobank data |
| title_full_unstemmed | Associations of physical activity with the risks of osteoarthritis and subtypes: a population-based cohort study of UK Biobank data |
| title_short | Associations of physical activity with the risks of osteoarthritis and subtypes: a population-based cohort study of UK Biobank data |
| title_sort | associations of physical activity with the risks of osteoarthritis and subtypes a population based cohort study of uk biobank data |
| topic | physical activity osteoarthritis uk biobank osteoarthritis (oa) hips bmi knee osteoarthritis knees cox proportional hazards models diabetes mellitus obesity hypertension depression |
| url | https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.147.BJR-2024-0529.R1 |
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