CD39+ conventional CD4+ T cells with exhaustion traits and cytotoxic potential infiltrate tumors and expand upon CTLA-4 blockade

CD39+ conventional CD4+ T cells with exhaustion traits and cytotoxic potential infiltrate tumors and expand upon CTLA-4 blockade

Conventional CD4+ T (Tconv) lymphocytes play important roles in tumor immunity; however, their contribution to tumor elimination remains poorly understood. Here, we describe a subset of tumor-infiltrating Tconv cells characterized by the expression of CD39. In several mouse cancer models, we observe...

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Bibliographic Details
Main Authors: Sabrina N. Bossio, Carolina Abrate, Jimena Tosello Boari, Constanza Rodriguez, Fernando P. Canale, María C. Ramello, Valentina Brunotto, Wilfrid Richer, Dario Rocha, Christine Sedlik, Anne Vincent-Salomon, Edith Borcoman, Andres Del Castillo, Adriana Gruppi, Elmer Fernandez, Eva V. Acosta Rodríguez, Eliane Piaggio, Carolina L. Montes
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:OncoImmunology
Subjects:
Cancer
CD39
conventional CD4+ T cells
cytotoxicity
exhaustion
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2023.2246319
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