An in-depth investigation of NAs-induced osteoporosis adverse events: a real-world, network toxicology and molecular docking analysis

An in-depth investigation of NAs-induced osteoporosis adverse events: a real-world, network toxicology and molecular docking analysis

BackgroundNucleoside and nucleotide analogs are one of the mainstays of treatment for chronic hepatitis B, but their effects on bone density are highly controversial.MethodsIn this study, four pharmacovigilance analysis methods and Bonferroni-corrected p-values were used to analyze the FDA Adverse E...

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Bibliographic Details
Main Authors: Jingkai Di, Shuang Wang, Lujia Liu, Likun Qi, Zijian Guo, Yingda Qin, Chuan Xiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Medicine
Subjects:
adefovir
tenofovir
osteoporosis
G protein-coupled receptor
IL-17
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2025.1605024/full
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