Adjunctive use of p16 immunohistochemistry for optimizing management of CIN lesions in a high‐risk human papillomavirus‐positive population

Adjunctive use of p16 immunohistochemistry for optimizing management of CIN lesions in a high‐risk human papillomavirus‐positive population

Abstract Introduction Immunostaining with p16INK4a (p16), a tumor‐suppressor surrogate protein biomarker for high‐risk human papillomavirus (hrHPV) oncogenic activity, may complement standard hematoxylin and eosin (H&E) histology review, and provide more objective criteria to support the cervica...

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Main Authors: Renée M. F. Ebisch, L. Lucia Rijstenberg, Gilda Ghazi Soltani, Judith van derHorst, Judith E. M. Vedder, Meyke Hermsen, Remko P. Bosgraaf, Leon F. A. G. Massuger, Chris J. L. M. Meijer, Daniëlle A. M. Heideman, Folkert J. vanKemenade, Willem J. G. Melchers, Ruud L. M. Bekkers, Albert G. Siebers, Johan Bulten
Format: Article
Language:English
Published: Wiley 2022-11-01
Series:Acta Obstetricia et Gynecologica Scandinavica
Subjects:
cervical cancer
cervical intraepithelial neoplasia
human papillomavirus
immunohistochemistry
p16
Online Access:https://doi.org/10.1111/aogs.14459
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