The pan-immune-inflammation value predicts prognosis and chemotherapy-related adverse events in Wilms’ tumor patients
Abstract Background Wilms’ tumor (WT) is a common renal malignancy in children. Although certain patient groups exhibit high survival rates, those experiencing recurrence, metastasis, or chemoresistance face significant challenges. The identification of reliable prognostic markers is essential for a...
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BMC
2025-06-01
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| Online Access: | https://doi.org/10.1186/s12885-025-14391-7 |
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| author | Kongkong Cui Jie Lin Peng Hong Honggang Fang Zaihong Hu Zhiqiang Gao Xiaomao Tian Qinlin Shi Guanghui Wei |
| author_facet | Kongkong Cui Jie Lin Peng Hong Honggang Fang Zaihong Hu Zhiqiang Gao Xiaomao Tian Qinlin Shi Guanghui Wei |
| author_sort | Kongkong Cui |
| collection | DOAJ |
| description | Abstract Background Wilms’ tumor (WT) is a common renal malignancy in children. Although certain patient groups exhibit high survival rates, those experiencing recurrence, metastasis, or chemoresistance face significant challenges. The identification of reliable prognostic markers is essential for adapting treatment strategies to enhance survival rates and reduce chemotherapy-related adverse events (CRAEs). Methods This study included patients diagnosed with WT at our institution. Inflammatory biomarkers were measured from pre-treatment blood tests, and their associations with event-free survival (EFS) and overall survival (OS) were evaluated using Kaplan-Meier and Cox regression analyses. The relationship between biomarkers and CRAEs was examined through logistic regression. Results Multifactorial Cox regression analysis identified tumor stage (HR = 4.68, 95% CI: 1.58–13.87, p = 0.005), pan-immune-inflammation value (PIV) (HR = 3.94, 95% CI: 1.80–8.60, p < 0.001), and neutrophil-to-lymphocyte ratio (NLR) (HR = 0.40, 95% CI: 0.18–0.90, p = 0.027) as independent prognostic factors for EFS. Multivariate Cox regression revealed that stage IV (HR = 12.24, 95% CI: 1.56–95.85, p = 0.017) and PIV levels exceeding 246.4 (HR = 5.50, 95% CI: 2.13–14.19, p < 0.001) were significant predictors for OS. Additionally, high PIV (OR 2.32, 95% CI: 1.15–4.67, p = 0.018) independently predicted the occurrence of CRAEs. Conclusion WT patients with higher PIV levels showed significant associations with poorer EFS, worse OS, and an increased likelihood of developing CRAEs during treatment. |
| format | Article |
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| institution | OA Journals |
| issn | 1471-2407 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
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| series | BMC Cancer |
| spelling | doaj-art-c2c0bd2de2b646ac8b4932971e0e4f902025-08-20T02:05:13ZengBMCBMC Cancer1471-24072025-06-0125111010.1186/s12885-025-14391-7The pan-immune-inflammation value predicts prognosis and chemotherapy-related adverse events in Wilms’ tumor patientsKongkong Cui0Jie Lin1Peng Hong2Honggang Fang3Zaihong Hu4Zhiqiang Gao5Xiaomao Tian6Qinlin Shi7Guanghui Wei8Department of Urology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and DisordersDepartment of Urology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and DisordersDepartment of Urology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and DisordersDepartment of Urology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and DisordersDepartment of Urology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and DisordersDepartment of Urology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and DisordersDepartment of Urology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and DisordersDepartment of Urology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and DisordersDepartment of Urology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and DisordersAbstract Background Wilms’ tumor (WT) is a common renal malignancy in children. Although certain patient groups exhibit high survival rates, those experiencing recurrence, metastasis, or chemoresistance face significant challenges. The identification of reliable prognostic markers is essential for adapting treatment strategies to enhance survival rates and reduce chemotherapy-related adverse events (CRAEs). Methods This study included patients diagnosed with WT at our institution. Inflammatory biomarkers were measured from pre-treatment blood tests, and their associations with event-free survival (EFS) and overall survival (OS) were evaluated using Kaplan-Meier and Cox regression analyses. The relationship between biomarkers and CRAEs was examined through logistic regression. Results Multifactorial Cox regression analysis identified tumor stage (HR = 4.68, 95% CI: 1.58–13.87, p = 0.005), pan-immune-inflammation value (PIV) (HR = 3.94, 95% CI: 1.80–8.60, p < 0.001), and neutrophil-to-lymphocyte ratio (NLR) (HR = 0.40, 95% CI: 0.18–0.90, p = 0.027) as independent prognostic factors for EFS. Multivariate Cox regression revealed that stage IV (HR = 12.24, 95% CI: 1.56–95.85, p = 0.017) and PIV levels exceeding 246.4 (HR = 5.50, 95% CI: 2.13–14.19, p < 0.001) were significant predictors for OS. Additionally, high PIV (OR 2.32, 95% CI: 1.15–4.67, p = 0.018) independently predicted the occurrence of CRAEs. Conclusion WT patients with higher PIV levels showed significant associations with poorer EFS, worse OS, and an increased likelihood of developing CRAEs during treatment.https://doi.org/10.1186/s12885-025-14391-7Wilms tumorRisk stratificationNomogramOverall survivalChemotherapy-related adverse events |
| spellingShingle | Kongkong Cui Jie Lin Peng Hong Honggang Fang Zaihong Hu Zhiqiang Gao Xiaomao Tian Qinlin Shi Guanghui Wei The pan-immune-inflammation value predicts prognosis and chemotherapy-related adverse events in Wilms’ tumor patients BMC Cancer Wilms tumor Risk stratification Nomogram Overall survival Chemotherapy-related adverse events |
| title | The pan-immune-inflammation value predicts prognosis and chemotherapy-related adverse events in Wilms’ tumor patients |
| title_full | The pan-immune-inflammation value predicts prognosis and chemotherapy-related adverse events in Wilms’ tumor patients |
| title_fullStr | The pan-immune-inflammation value predicts prognosis and chemotherapy-related adverse events in Wilms’ tumor patients |
| title_full_unstemmed | The pan-immune-inflammation value predicts prognosis and chemotherapy-related adverse events in Wilms’ tumor patients |
| title_short | The pan-immune-inflammation value predicts prognosis and chemotherapy-related adverse events in Wilms’ tumor patients |
| title_sort | pan immune inflammation value predicts prognosis and chemotherapy related adverse events in wilms tumor patients |
| topic | Wilms tumor Risk stratification Nomogram Overall survival Chemotherapy-related adverse events |
| url | https://doi.org/10.1186/s12885-025-14391-7 |
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