Axillary adipose tissue–derived lymphatic endothelial cells exhibit distinct transcriptomic signatures reflecting lymphatic invasion status in breast cancer

Axillary adipose tissue–derived lymphatic endothelial cells exhibit distinct transcriptomic signatures reflecting lymphatic invasion status in breast cancer

Abstract Background Lymphatics provide a route for breast cancer cells to metastasize. Lymphatic endothelial cells (LECs), which form the structure of lymphatic vessels, play a key role in this process. Although LECs are pivotal in cancer progression, studies often rely on commercially available cel...

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Main Authors: Asumi Iesato, Jun Suzuka, Kazutaka Otsuji, Tomo Osako, Nami Yamashita, Yuka Inoue, Tetsuyo Maeda, Natsue Uehiro, Kazuyo Yoshida, Yoko Takahashi, Kohei Kumegawa, Sumito Saeki, Liying Yang, Ai Tsuchiya, Kana Sakiyama, Miwa Tanaka, Takehiko Sakai, Shinji Ohno, Tetsuo Noda, Takayuki Ueno, Reo Maruyama
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Breast Cancer Research
Subjects:
Lymphatic endothelial cells
Breast cancer
Cell isolation
Lymphatic invasion
Gene expression analysis
Online Access:https://doi.org/10.1186/s13058-025-02067-w
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