The impact of carboplatin on pathologic complete response and survival based on HER2 low and HER2 zero status in triple negative breast cancer patients receiving neoadjuvant chemotherapy: a multicenter real-world analysis

The impact of carboplatin on pathologic complete response and survival based on HER2 low and HER2 zero status in triple negative breast cancer patients receiving neoadjuvant chemotherapy: a multicenter real-world analysis

Abstract Background and Objectives Triple-negative breast cancer (TNBC) has a poor prognosis, and neoadjuvant chemotherapy (NACT) is the standard treatment for locally advanced TNBC. In this study, we aimed to evaluate the efficacy of adding carboplatin to NACT regarding pathological complete respon...

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Main Authors: Sedat Yıldırım, Tugba Başoğlu, Akif Doğan, Goncagul Akdağ, Oguzcan Kınıkoğlu, Alper Topal, Ozkan Alan, Ali Alper Solmaz, Mustafa Gürbüz, Timucin Çil, Rumeysa Çolak, Mesut Yılmaz, Ali Kalem, Nadiye Sever, Nargiz Majıdova, Kubilay Karakoyun, Serhat Sekmek, Omer Saçlı, Melike Ozcelık, Deniz Işık, Heves Surmeli, Ozlem Nuray Sever, Hatice Odabas, Mahmut Emre Yıldırım, Nedim Turan
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Cancer
Subjects:
Triple negative breast cancer
HER2 status
Carboplatin
Neoadjuvant chemotherapy
Pathologic complete response
Online Access:https://doi.org/10.1186/s12885-025-14252-3
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