Investigating the role of eight SNPs in CHRNA3 for COPD susceptibility in the Chinese elderly population
Background Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality among the elderly in China. Genetic predisposition is a recognized risk factor for COPD, with CHRNA3 emerging as a promising candidate gene due to its involvement in smoking behavior and lung functi...
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Taylor & Francis Group
2025-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2025.2474726 |
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| author | Yamei Zheng Jie Zhao Meihua Liu Yunchan Liu Yipeng Ding Tian Xie |
| author_facet | Yamei Zheng Jie Zhao Meihua Liu Yunchan Liu Yipeng Ding Tian Xie |
| author_sort | Yamei Zheng |
| collection | DOAJ |
| description | Background Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality among the elderly in China. Genetic predisposition is a recognized risk factor for COPD, with CHRNA3 emerging as a promising candidate gene due to its involvement in smoking behavior and lung function. This study aimed to investigate the association between eight CHRNA3 SNPs and COPD susceptibility in the Chinese elderly population.Methods A total of 270 COPD patients and 271 healthy controls were included in the study. SNP genotyping was carried out using the Agena MassARRAY platform. Logistic regression analysis was employed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) to assess the association between the SNPs and COPD risk. Forest plots were generated using Sangerbox software to visually represent the association results. Additionally, haplotype blocks were constructed using Haploview 4.2 software to explore the potential impact of haplotypes on COPD risk.Results Our findings indicated that rs615470, rs660652, and rs472054 are associated with a reduced risk of COPD, while rs8040868 is associated with an increased risk. Linkage disequilibrium (LD) analysis identified a haplotype block encompassing rs76071148, rs615470, rs660652, rs472054 and rs578776. Notably, the haplotype TTAAG was associated with a reduced risk of COPD.Conclusion This study provides valuable insights into the genetic susceptibility of COPD among the elderly, particularly regarding the role of SNPs in CHRNA3. These findings contribute to a deeper understanding of the pathogenesis of COPD and may facilitate the discovery of novel therapeutic targets for COPD. |
| format | Article |
| id | doaj-art-c2bb317852c74d9db94892e315d4c3cb |
| institution | OA Journals |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj-art-c2bb317852c74d9db94892e315d4c3cb2025-08-20T02:38:23ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2025.2474726Investigating the role of eight SNPs in CHRNA3 for COPD susceptibility in the Chinese elderly populationYamei Zheng0Jie Zhao1Meihua Liu2Yunchan Liu3Yipeng Ding4Tian Xie5Department of Respiratory and Critical Care Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, ChinaDepartment of Respiratory and Critical Care Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, ChinaDepartment of Respiratory and Critical Care Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, ChinaDepartment of Respiratory and Critical Care Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, ChinaDepartment of Respiratory and Critical Care Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, ChinaDepartment of Respiratory and Critical Care Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, ChinaBackground Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality among the elderly in China. Genetic predisposition is a recognized risk factor for COPD, with CHRNA3 emerging as a promising candidate gene due to its involvement in smoking behavior and lung function. This study aimed to investigate the association between eight CHRNA3 SNPs and COPD susceptibility in the Chinese elderly population.Methods A total of 270 COPD patients and 271 healthy controls were included in the study. SNP genotyping was carried out using the Agena MassARRAY platform. Logistic regression analysis was employed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) to assess the association between the SNPs and COPD risk. Forest plots were generated using Sangerbox software to visually represent the association results. Additionally, haplotype blocks were constructed using Haploview 4.2 software to explore the potential impact of haplotypes on COPD risk.Results Our findings indicated that rs615470, rs660652, and rs472054 are associated with a reduced risk of COPD, while rs8040868 is associated with an increased risk. Linkage disequilibrium (LD) analysis identified a haplotype block encompassing rs76071148, rs615470, rs660652, rs472054 and rs578776. Notably, the haplotype TTAAG was associated with a reduced risk of COPD.Conclusion This study provides valuable insights into the genetic susceptibility of COPD among the elderly, particularly regarding the role of SNPs in CHRNA3. These findings contribute to a deeper understanding of the pathogenesis of COPD and may facilitate the discovery of novel therapeutic targets for COPD.https://www.tandfonline.com/doi/10.1080/07853890.2025.2474726COPDCHRNA3SNPselderlygenetic susceptibility |
| spellingShingle | Yamei Zheng Jie Zhao Meihua Liu Yunchan Liu Yipeng Ding Tian Xie Investigating the role of eight SNPs in CHRNA3 for COPD susceptibility in the Chinese elderly population Annals of Medicine COPD CHRNA3 SNPs elderly genetic susceptibility |
| title | Investigating the role of eight SNPs in CHRNA3 for COPD susceptibility in the Chinese elderly population |
| title_full | Investigating the role of eight SNPs in CHRNA3 for COPD susceptibility in the Chinese elderly population |
| title_fullStr | Investigating the role of eight SNPs in CHRNA3 for COPD susceptibility in the Chinese elderly population |
| title_full_unstemmed | Investigating the role of eight SNPs in CHRNA3 for COPD susceptibility in the Chinese elderly population |
| title_short | Investigating the role of eight SNPs in CHRNA3 for COPD susceptibility in the Chinese elderly population |
| title_sort | investigating the role of eight snps in chrna3 for copd susceptibility in the chinese elderly population |
| topic | COPD CHRNA3 SNPs elderly genetic susceptibility |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2025.2474726 |
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