Designing and Synthesising Novel Benzophenone Biscyclic Imides Comprising Drug Moity with Investigating their Antimicrobial Activity
The present work involved designing and synthesizing of a series of new. compounds which their molecules are composed from two biologically active components namely sulfamethoxazole or β-lactam containing drugs and cyclic imides. The target new compounds were synthesized by two steps in the first o...
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University of Baghdad, College of Science for Women
2022-10-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/6226 |
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| author | Zaynab Hussein Fadel Ahlam Marouf Al-Azzawi |
| author_facet | Zaynab Hussein Fadel Ahlam Marouf Al-Azzawi |
| author_sort | Zaynab Hussein Fadel |
| collection | DOAJ |
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The present work involved designing and synthesizing of a series of new. compounds which their molecules are composed from two biologically active components namely sulfamethoxazole or β-lactam containing drugs and cyclic imides. The target new compounds were synthesized by two steps in the first one a series of six bis (N-drug phthalamic acid_4-yl) ketone (1-6) were prepared from the reaction of sulfamethoxazole or β-lactam containing drugs with benzophenone 3, 3′, 4, 4′ -tetracarboxylic dianhydride.
In the second step, compounds (1-6) were introduced in dehydration reaction via fusion process producing the target compounds bis (N-drug phthalimidyl-4-yl) ketone (7-12). The antibacterial and antifungal high activities of the prepared compounds (7-12) were tested against (Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas auroginosa and Staphylococcus aurus) and all compounds showed good to high antibacterial activity. However, the maximum inhibition zone was 38 mm against Staphyloccus aurus, 36 mm against Bacillus subtilis, 35 mm against Pseudomonas auroginosa, 28mm against Klebsiella pneumoniae and 19 mm against Rhizosporium fungi.
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| format | Article |
| id | doaj-art-c2b8b059c28545e6977ff4c12348a24d |
| institution | DOAJ |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2022-10-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-c2b8b059c28545e6977ff4c12348a24d2025-08-20T03:20:30ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862022-10-0119510.21123/bsj.2022.6226Designing and Synthesising Novel Benzophenone Biscyclic Imides Comprising Drug Moity with Investigating their Antimicrobial ActivityZaynab Hussein Fadel0Ahlam Marouf Al-Azzawi1Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, IraqDepartment of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq The present work involved designing and synthesizing of a series of new. compounds which their molecules are composed from two biologically active components namely sulfamethoxazole or β-lactam containing drugs and cyclic imides. The target new compounds were synthesized by two steps in the first one a series of six bis (N-drug phthalamic acid_4-yl) ketone (1-6) were prepared from the reaction of sulfamethoxazole or β-lactam containing drugs with benzophenone 3, 3′, 4, 4′ -tetracarboxylic dianhydride. In the second step, compounds (1-6) were introduced in dehydration reaction via fusion process producing the target compounds bis (N-drug phthalimidyl-4-yl) ketone (7-12). The antibacterial and antifungal high activities of the prepared compounds (7-12) were tested against (Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas auroginosa and Staphylococcus aurus) and all compounds showed good to high antibacterial activity. However, the maximum inhibition zone was 38 mm against Staphyloccus aurus, 36 mm against Bacillus subtilis, 35 mm against Pseudomonas auroginosa, 28mm against Klebsiella pneumoniae and 19 mm against Rhizosporium fungi. https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/6226Bis (N-drug phthalamic acid-4-yl) ketone, Bis (N-drug phthalimidyl-4-yl) ketone, Cyclic imide |
| spellingShingle | Zaynab Hussein Fadel Ahlam Marouf Al-Azzawi Designing and Synthesising Novel Benzophenone Biscyclic Imides Comprising Drug Moity with Investigating their Antimicrobial Activity مجلة بغداد للعلوم Bis (N-drug phthalamic acid-4-yl) ketone, Bis (N-drug phthalimidyl-4-yl) ketone, Cyclic imide |
| title | Designing and Synthesising Novel Benzophenone Biscyclic Imides Comprising Drug Moity with Investigating their Antimicrobial Activity |
| title_full | Designing and Synthesising Novel Benzophenone Biscyclic Imides Comprising Drug Moity with Investigating their Antimicrobial Activity |
| title_fullStr | Designing and Synthesising Novel Benzophenone Biscyclic Imides Comprising Drug Moity with Investigating their Antimicrobial Activity |
| title_full_unstemmed | Designing and Synthesising Novel Benzophenone Biscyclic Imides Comprising Drug Moity with Investigating their Antimicrobial Activity |
| title_short | Designing and Synthesising Novel Benzophenone Biscyclic Imides Comprising Drug Moity with Investigating their Antimicrobial Activity |
| title_sort | designing and synthesising novel benzophenone biscyclic imides comprising drug moity with investigating their antimicrobial activity |
| topic | Bis (N-drug phthalamic acid-4-yl) ketone, Bis (N-drug phthalimidyl-4-yl) ketone, Cyclic imide |
| url | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/6226 |
| work_keys_str_mv | AT zaynabhusseinfadel designingandsynthesisingnovelbenzophenonebiscyclicimidescomprisingdrugmoitywithinvestigatingtheirantimicrobialactivity AT ahlammaroufalazzawi designingandsynthesisingnovelbenzophenonebiscyclicimidescomprisingdrugmoitywithinvestigatingtheirantimicrobialactivity |