Neuromodulatory Effects of Transcranial Direct Current Stimulation on Motor Excitability in Rats
Transcranial direct current stimulation (tDCS) is a noninvasive technique for modulating neural plasticity and is considered to have therapeutic potential in neurological disorders. For the purpose of translational neuroscience research, a suitable animal model can be ideal for providing a stable co...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2019/4252943 |
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| author | Hui-Hua Liu Xiao-Kuo He Hsin-Yung Chen Chih-Wei Peng Alexander Rotenberg Chi-Hung Juan Yu-Cheng Pei Hao-Li Liu Yung-Hsiao Chiang Jia-Yi Wang Xiao-Jun Feng Ying-Zu Huang Tsung-Hsun Hsieh |
| author_facet | Hui-Hua Liu Xiao-Kuo He Hsin-Yung Chen Chih-Wei Peng Alexander Rotenberg Chi-Hung Juan Yu-Cheng Pei Hao-Li Liu Yung-Hsiao Chiang Jia-Yi Wang Xiao-Jun Feng Ying-Zu Huang Tsung-Hsun Hsieh |
| author_sort | Hui-Hua Liu |
| collection | DOAJ |
| description | Transcranial direct current stimulation (tDCS) is a noninvasive technique for modulating neural plasticity and is considered to have therapeutic potential in neurological disorders. For the purpose of translational neuroscience research, a suitable animal model can be ideal for providing a stable condition for identifying mechanisms that can help to explore therapeutic strategies. Here, we developed a tDCS protocol for modulating motor excitability in anesthetized rats. To examine the responses of tDCS-elicited plasticity, the motor evoked potential (MEP) and MEP input-output (IO) curve elicited by epidural motor cortical electrical stimulus were evaluated at baseline and after 30 min of anodal tDCS or cathodal tDCS. Furthermore, a paired-pulse cortical electrical stimulus was applied to assess changes in the inhibitory network by measuring long-interval intracortical inhibition (LICI) before and after tDCS. In the results, analogous to those observed in humans, the present study demonstrates long-term potentiation- (LTP-) and long-term depression- (LTD-) like plasticity can be induced by tDCS protocol in anesthetized rats. We found that the MEPs were significantly enhanced immediately after anodal tDCS at 0.1 mA and 0.8 mA and remained enhanced for 30 min. Similarly, MEPs were suppressed immediately after cathodal tDCS at 0.8 mA and lasted for 30 min. No effect was noted on the MEP magnitude under sham tDCS stimulation. Furthermore, the IO curve slope was elevated following anodal tDCS and presented a trend toward diminished slope after cathodal tDCS. No significant differences in the LICI ratio of pre- to post-tDCS were observed. These results indicated that developed tDCS schemes can produce consistent, rapid, and controllable electrophysiological changes in corticomotor excitability in rats. This newly developed tDCS animal model could be useful to further explore mechanical insights and may serve as a translational platform bridging human and animal studies, establishing new therapeutic strategies for neurological disorders. |
| format | Article |
| id | doaj-art-c2b5c8df81514b2eadf2a1ade3fa4712 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-c2b5c8df81514b2eadf2a1ade3fa47122025-02-03T00:59:03ZengWileyNeural Plasticity2090-59041687-54432019-01-01201910.1155/2019/42529434252943Neuromodulatory Effects of Transcranial Direct Current Stimulation on Motor Excitability in RatsHui-Hua Liu0Xiao-Kuo He1Hsin-Yung Chen2Chih-Wei Peng3Alexander Rotenberg4Chi-Hung Juan5Yu-Cheng Pei6Hao-Li Liu7Yung-Hsiao Chiang8Jia-Yi Wang9Xiao-Jun Feng10Ying-Zu Huang11Tsung-Hsun Hsieh12Department of Rehabilitation Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, ChinaSchool of Physical Therapy and Graduate Institute of Rehabilitation Science, Chang Gung University, Taoyuan, TaiwanDepartment of Occupational Therapy and Institute of Behavioral Sciences, College of Medicine, Chang Gung University, Taoyuan, TaiwanSchool of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, TaiwanDepartment of Neurology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USAInstitute of Cognitive Neuroscience, National Central University, Taoyuan, TaiwanDepartment of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Taoyuan, TaiwanDepartment of Electrical Engineering, Chang Gung University, Taoyuan, TaiwanDepartment of Neurosurgery, Taipei Medical University Hospital, Taipei, TaiwanGraduate Institute of Medical Sciences, College of Medical Science and Technology, Taipei Medical University, Taipei, TaiwanDepartment of Rehabilitation Medicine, The Second Hospital of Anhui Medical University and Anhui Medical University, Hefei, ChinaDepartment of Neurology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taipei, TaiwanSchool of Physical Therapy and Graduate Institute of Rehabilitation Science, Chang Gung University, Taoyuan, TaiwanTranscranial direct current stimulation (tDCS) is a noninvasive technique for modulating neural plasticity and is considered to have therapeutic potential in neurological disorders. For the purpose of translational neuroscience research, a suitable animal model can be ideal for providing a stable condition for identifying mechanisms that can help to explore therapeutic strategies. Here, we developed a tDCS protocol for modulating motor excitability in anesthetized rats. To examine the responses of tDCS-elicited plasticity, the motor evoked potential (MEP) and MEP input-output (IO) curve elicited by epidural motor cortical electrical stimulus were evaluated at baseline and after 30 min of anodal tDCS or cathodal tDCS. Furthermore, a paired-pulse cortical electrical stimulus was applied to assess changes in the inhibitory network by measuring long-interval intracortical inhibition (LICI) before and after tDCS. In the results, analogous to those observed in humans, the present study demonstrates long-term potentiation- (LTP-) and long-term depression- (LTD-) like plasticity can be induced by tDCS protocol in anesthetized rats. We found that the MEPs were significantly enhanced immediately after anodal tDCS at 0.1 mA and 0.8 mA and remained enhanced for 30 min. Similarly, MEPs were suppressed immediately after cathodal tDCS at 0.8 mA and lasted for 30 min. No effect was noted on the MEP magnitude under sham tDCS stimulation. Furthermore, the IO curve slope was elevated following anodal tDCS and presented a trend toward diminished slope after cathodal tDCS. No significant differences in the LICI ratio of pre- to post-tDCS were observed. These results indicated that developed tDCS schemes can produce consistent, rapid, and controllable electrophysiological changes in corticomotor excitability in rats. This newly developed tDCS animal model could be useful to further explore mechanical insights and may serve as a translational platform bridging human and animal studies, establishing new therapeutic strategies for neurological disorders.http://dx.doi.org/10.1155/2019/4252943 |
| spellingShingle | Hui-Hua Liu Xiao-Kuo He Hsin-Yung Chen Chih-Wei Peng Alexander Rotenberg Chi-Hung Juan Yu-Cheng Pei Hao-Li Liu Yung-Hsiao Chiang Jia-Yi Wang Xiao-Jun Feng Ying-Zu Huang Tsung-Hsun Hsieh Neuromodulatory Effects of Transcranial Direct Current Stimulation on Motor Excitability in Rats Neural Plasticity |
| title | Neuromodulatory Effects of Transcranial Direct Current Stimulation on Motor Excitability in Rats |
| title_full | Neuromodulatory Effects of Transcranial Direct Current Stimulation on Motor Excitability in Rats |
| title_fullStr | Neuromodulatory Effects of Transcranial Direct Current Stimulation on Motor Excitability in Rats |
| title_full_unstemmed | Neuromodulatory Effects of Transcranial Direct Current Stimulation on Motor Excitability in Rats |
| title_short | Neuromodulatory Effects of Transcranial Direct Current Stimulation on Motor Excitability in Rats |
| title_sort | neuromodulatory effects of transcranial direct current stimulation on motor excitability in rats |
| url | http://dx.doi.org/10.1155/2019/4252943 |
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