Endosomal chloride/proton exchangers need inhibitory TMEM9 β-subunits for regulation and prevention of disease-causing overactivity

Endosomal chloride/proton exchangers need inhibitory TMEM9 β-subunits for regulation and prevention of disease-causing overactivity

Abstract The function of endosomes critically depends on their ion homeostasis. A crucial role of luminal Cl−, in addition to that of H+, is increasingly recognized. Both ions are transported by five distinct endolysosomal CLC chloride/proton exchangers. Dysfunction of each of these transporters ent...

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Bibliographic Details
Main Authors: Rosa Planells-Cases, Viktoriia Vorobeva, Sumanta Kar, Franziska W. Schmitt, Uwe Schulte, Marina Schrecker, Richard K. Hite, Bernd Fakler, Thomas J. Jentsch
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58546-3
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