Isolation of Ten New Sesquiterpenes and New Abietane-Type Diterpenoid with Immunosuppressive Activity from Marine Fungus <i>Eutypella</i> sp.
<b>Background<b>:</b></b> Ten new sesquiterpenes, including eight eremophilane-type sesquiterpenes (<b>1</b>–<b>8</b>) and two compounds (<b>9</b>–<b>10</b>) with a cyclopentane ring, representing an undescribed subtype of sesqu...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
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| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/18/5/737 |
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| Summary: | <b>Background<b>:</b></b> Ten new sesquiterpenes, including eight eremophilane-type sesquiterpenes (<b>1</b>–<b>8</b>) and two compounds (<b>9</b>–<b>10</b>) with a cyclopentane ring, representing an undescribed subtype of sesquiterpene, along with a new abietane-type diterpenoid (<b>11</b>), were isolated and identified from a deep-sea-derived fungus: <i>Eutypella</i> sp. <b>Methods:</b> Their structures were elucidated on the basis of various spectroscopic analyses, mainly including nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HRESIMS) data, <sup>13</sup>C NMR calculations with DP4+ probability analyses, electronic circular dichroism (ECD) calculations, and single-crystal X-ray diffraction experiments. <b>Results:</b> Furthermore, compound <b>11</b> exhibited potent immunosuppressive activity with IC<sub>50</sub> values of 8.99 ± 1.08 μM in a lipopolysaccharide (LPS) model and 5.39 ± 0.20 μM in a concanavalin A (ConA) model. |
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| ISSN: | 1424-8247 |