Characterizing the plasma protein binding profiles of chemistry diversified antisense oligonucleotides in human and mouse plasma using an ultrafiltration method

Characterizing the plasma protein binding profiles of chemistry diversified antisense oligonucleotides in human and mouse plasma using an ultrafiltration method

IntroductionPlasma protein binding plays a significant role in influencing the pharmacokinetic and pharmacodynamic properties of drugs. This study focuses on examining two pairs of sequence-matched ASOs: phosphorodiamidate morpholino oligomers (PMOs) and 2’-O-methoxyethyl/phosphorothioate (MOE/PS)-m...

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Bibliographic Details
Main Authors: Cassandra Yun, Kazuki Fukami, Raku Shinkyo, Rongrong (Rosa) Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
antisense oligonucleotides
plasma protein binding
ultrafiltration
MOE
PMO
binding saturation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1481937/full
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